Endocrine Abstracts

Context: Since the exact cause of type 1 diabetes mellitus (T1DM) remains unclear, the detection of novel biomarkers is necessary to complement the information obtained from the presence of autoantibodies together with genetic and environmental risk factors. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate gene expression. Changes in their expression were described in several pathological conditions, including autoimmune diseases. Circul...

Introduction: Diabetic kidney disease (DKD) is the major cause of end-stage renal disease; however, the pathogenesis of this disease is not fully understood. Currently available therapies are not totally efficacious in the treatment and prognosis of DKD, suggesting that further understanding of the molecular mechanisms underlying the pathogenesis of this disease is necessary to improve its management. Recently, research on microRNAs (miRNAs) has become a hotspot because of the...

Context: Diabetic kidney disease (DKD) is a common microvascular complication that affects approximately 40% of patients with diabetes mellitus (DM). This complication is the leading cause of end-stage renal disease (ESRD) in patients starting renal replacement therapy and is associated with increased cardiovascular mortality. Although a tight glycemic control is able to reduce the development and delay the progression of DKD, current therapies are still not totally effective ...