Searchable abstracts of presentations at key conferences in endocrinology

ea0044p169 | Neuroendocrinology and pituitary | SFEBES2016

Significance of cumulative GH exposure in patients with acromegaly: comparison between patients in whom control was achieved and patients with active disease

Varadhan Lakshminarayanan , Clayton Richard

Aim: The aim of the study was to assess the differences between patients in remission in acromegaly and those with active ongoing disease, using cumulative GH measurement as risk factor for various complications.Methods: A retrospective observational analysis of all patients with acromegaly treated at a tertiary referral centre since the initiation of service (~50 years) was conducted. Cumulative GH exposure was calculated as a sum of averages of GH leve...

ea0059p131 | Neuroendocrinology and pituitary | SFEBES2018

The importance of achieving disease control in Acromegaly: a retrospective single centre analysis

Varadhan Lakshminarayanan , Jose Biju , Clayton Richard

Aim: Acromegaly is associated with higher mortality and morbidity, and achieving disease control can be challenging. The aim of this study was to assess the morbidity and mortality associated with active acromegaly compared to patients in whom disease control was achieved.Methods: Retrospective analysis of all patients treated with acromegaly at a university hospital between 1948 and 2014 was performed. Mortality rates and development of new cardiovascul...

ea0090p156 | Pituitary and Neuroendocrinology | ECE2023

Incidence of complications of acromegaly 10 years after achieving biochemical control of GH – a single centre retrospective observational study

Mulholland Sarah , Clayton Richard , Jose Biju , Varadhan Lakshminarayanan

Aim: Acromegaly is associated with multiple co-morbidities including diabetes mellitus (DM), obstructive sleep apnoea (OSA), arthropathy, cardiovascular events and malignancies. Early diagnosis and treatment, with an intention to cure or control the growth hormone (GH) exposure can reduce risk of these complications. The aim of this study is to assess the development of acromegaly-related complications amongst patients who have completed at least 10 years of follow up after ac...

ea0090ep152 | Calcium and Bone | ECE2023

Incidental hypercalcemia during denosumab treatment for osteoporosis: rebound phenomenon or occult primary hyperparathyroidism

Varadhan Lakshminarayanan , Adams Elizabeth , Padmanabhan Nishita , Paskins Zoe

Introduction: Denosumab is an important treatment option for osteoporosis. Rebound hypercalcemia on discontinuation of denosumab is well documented. Denosumab can increase PTH, peaking within 2-4 weeks of administration and subsiding thereafter, therefore making diagnosis of primary hyperparathyroidism (pHPT) difficult. The aim of our case series is to review the calcium fluctuations in relationship to timing of denosumab administration and identify the possibility of rebound ...

ea0038p245 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Obstructive sleep apnoea and bariatric surgery: the need for more universal screening and post-operative follow up

Martinou Chrysiis , Nayak Ullal , Katreddy Mahesh , Varughese George , Varadhan Lakshminarayanan

Aim: Bariatric surgery can provide significant weight loss but a complete resolution obstructive sleep apnoea (OSA) cannot be predicted. The aim of our audit was to assess the prevalence of OSA in bariatric clinics and outcomes after malabsorptive bariatric surgery.Methods: Retrospective observational analysis was performed on patients who had undergone bariatric surgery (laparoscopic gastric bypass and sleeve gastrectomy) and completed a minimum of 6 mo...

ea0034p387 | Thyroid | SFEBES2014

Is there a need to change how we approach a patient with hyperthyroidism?

Varadhan Lakshminarayanan , Altaf Anney , Varughese George , Sankar Sailesh

Aim: Establishing the aetiological diagnosis of hyperthyroidism relies on clinical examination, ultrasound imaging and thyroid antibodies; however there is a wide variation in practice in which of the aforementioned approaches are used. The aim of our study was to assess the reliability of clinical examination of thyroid gland in patients with hyperthyroidism, using ultrasound (US) as the reference.Methods: Case notes and letters of patients of 133 patie...

ea0034p430 | Thyroid | SFEBES2014

Pre-operative cytology vs post-operative histology in thyroid nodules

Gill Gurmit , Wilson Paul , Kalyanasundaram Karthik , Varughese George , Varadhan Lakshminarayanan

Aim: The aim of our study was to assess the correlation between pre-operative fine needles aspiration based cytology with post-operative histology in patients with thyroid nodules.Methods: A retrospective analysis of patients who had thyroidectomy (hemi, subtotal, or total) was conducted and information on histology was obtained. Pre-operative FNA (done once or twice) was also obtained and compared with histology. Patients operated for GravesÂ’ disea...

ea0070ep429 | Thyroid | ECE2020

An audit of monitoring of fetus in pregnant women with hyperthyroidism

Quader Monzoor , Nayak Ananth , Masson Geraldine , Usman Saada , Varadhan Lakshminarayanan

Aim: Hyperthyroidism can affect pregnancy outcomes based on activity of the disease, ongoing use of anti-thyroid drugs (ATD) and TSH receptor antibody (TRAB) positivity. The aim of our audit was to analyse the outcomes of fetal monitoring in pregnant women with previous or current history of active hyperthyroidismMethods: The data on all patients with hyperthyroidism and pregnancy over 3 years was collected. The local guidelines recommend TRAB check at 2...

ea0028p202 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Bariatric surgery and Vitamin D deficiency: Pre-operative treatment or post-operative supplementation

Ataullah Zahid , Cheruvu Chandra , Clayton Richard , Varughese George , Varadhan Lakshminarayanan

Introduction: Bariatric surgery is an important treatment option for morbid obesity. The current guidelines recommend testing and supplementation of vitamin D postoperatively. The aim of our study was to assess the need for preoperative proactive supplementation of vitamin D. Methods All patients who had restrictive bariatric surgery (laparoscopic gastric bypass or sleeve gastrectomy) between January 2010 and June 2011 were included. Data was collected retrospectively from com...

ea0025p56 | Clinical biochemistry | SFEBES2011

Hormone profile of patients referred for Bariatric surgery

Varadhan Lakshminarayanan , Cheruvu C V N , Varughese George , Clayton Richard

Aim: An increasing proportion of patients are referred to endocrine clinics for assessment of an endocrine reason for obesity. The aim of our study was to assess the hormone profiles of patients referred for bariatric surgery.Methods: Patients referred to bariatric surgery clinic were investigated for hypothyroidism (TSH, T4), CushingÂ’s disease (2 mg-overnight dexamethasone suppression test), acromegaly (IGF1) and Vitamin D deficiency (PT...