Endocrine Abstracts

Background of the study: There is lack of data in the Czech Republic on iodine status in patients suffering from diabetes mellitus type 1 (DM1) considered to be at risk of iodine deficiency.Subjects and methods: A total of 54 males and 51 females ‒ median (25th, 75th percentile): age (years) 42 (31, 55); BMI 25.9 (23.3, 29.7); HbA1c (mmol/mol) 61 (51.2, 71.0) treated for DM1 were included in this cross–sectional study. In addition to iodine s...

Fasting induces profound metabolic changes in order to decrease energy expenditure and to conserve energy. One of the major adaptations is downregulation of the hypothalamus–pituitary–thyroid (HPT) axis, characterized by decreased serum thyroid hormone levels without an increase in serum TSH or in TRH expression in the hypothalamic paraventricular nucleus (PVN). Leptin has been proposed as a critical signal initiating the neuroendocrine response to fasting as it decr...

Coupling metabolic processes to nutrient availability is essential for survival. The nuclear receptors PPARα and FXR regulate adaptive liver metabolism in the fasted-state and fed-state, respectively, through a complex mechanism that is incompletely understood. Here, we show that hepatic expression of the steroidogenic enzyme Cyp17al is strikingly regulated by feed-fast cycles via a repressive nuclear receptor cascade involving bile-acid:FXR signalling. Using both gain- a...