Searchable abstracts of presentations at key conferences in endocrinology

ea0029p171 | Bone & Osteoporosis | ICEECE2012

Denosumab increases BMD in primary hyperparathyroidism

Misiorowski W. , Zgliczynski W.

Primary hyperparathyroidism (PHPT) is often associated with reduced bone mineral density (BMD). An open-labeled, prospective trial was conducted to determine whether denosumab 60 mg subcutaneously given every 6 months, maintains or improves BMD in patients with PHPT.Six patients had symptomatic PHPT and met surgical guidelines however refused surgery, and twelve patients had mild PHPT, asymptomatic except low BMD. The primary outcome index, BMD, was meas...

ea0032s28.1 | Autoimmune endocrine disease - Old and new players | ECE2013

Autoimmune thyroid disease

Wiersinga W

Graves’ hyperthyroidism (GH) and Hashimoto’s hypothyroidism (HH) are the opposite ends of the clinical expression of autoimmune thyroid diseases (AITD). AITD are multifactorial ‘complex’ diseases in which immune responses against thyroid antigens develop in genetic susceptible subjects, provoked by environmental factors. Susceptibility genes include immunoregulatory genes (HLA, CTLA-4, PTPN22, CD4 and FCRL3) and thyroid-specific genes (TSHR and Tg). Environ...

ea0029s23.1 | Advances in regulation of aldosterone synthesis | ICEECE2012

Regulation of aldosterone synthase expression in normal adrenal and primary aldosteronism

Rainey W.

The human adrenal cortex can be divided into distinct zones that have both morphologic and biochemical differences. The production of aldosterone in the zona glomerulosa can be traced to the zone-specific expression of the enzymes involved in steroid biosynthesis. This is particularly true for its expression of the enzyme aldosterone synthase (CYP11B2). For aldosterone biosynthesis, CYP11B2 expression has often been called the ‘late rate-limiting’ step. We and others...

ea0029s33.3 | Pollution Related Acromegaly | ICEECE2012

Effect of iodine intake on thyroid diseases in China

Teng W.

It has been 14 years since universal salt iodization was conducted legislatively throughout China in 1996, and the residents experienced the period of excessive iodine intake (MUI>300 μg/l) for 6 years and more than adequate iodine intake (MUI 240 μg/l) for 8 years, and now the status of iodine is normally adequate (MUI 180 μg/l).During this period, we completed several epidemiological studies on the relationship between iodine intake ...

ea0029en2.2 | (1) | ICEECE2012

The role of the endocrine nurse in the diagnosis and management of the patient with Cushing’s syndrome

Geilvoet W

Cushing’s syndrome is a rare disease and difficult to diagnose. A number of different physical and psychological signs and symptoms can be present. Lots of patients have symptoms many years before diagnosis. Endocrine nurses can play an important role for these patients during diagnosis, medical or surgical treatment and in the postoperative phase.During the diagnostic phase, nurses need to know why patients must undergo certain endocrine function t...

ea0029mte13 | (1) | ICEECE2012

Graves’ ophthalmopathy

Wiersinga W.

Management of Graves’ ophthalmopathy (GO) requires knowledge of smoking behaviour, thyroid function and antibodies, and activity and severity of the ophthalmopathy.Smokers should be strongly adviced to stop smoking because outcome of Graves’ disease is less favourable in smokers compared to nonsmokers.High serum concentrations of TSH receptor antibodies (TBII) are associated with a more severe and protracted course of GO....

ea0029p570 | Diabetes | ICEECE2012

DNA methylation influenced β-arrestin 2 expression in type 2 diabetes patients

Zhong W

Background: Hyperglycemia and glucose intolerance are perhaps the most common pathophysiologies associated with diabetes. β-Arrestin 2, component of G-protein coupled receptor signaling, has been shown to be down-regulated in insulin resistant and type 2 diabetic mouse models. However, if this down-regulation also existed in diabetic humans, and the possible mechanisms of this differential expression in normal and type 2 diabetes were not clear.Meth...

ea0029p710 | Diabetes | ICEECE2012

Effects of flaxseed oil on anti-oxidative system and membrane deformation of human erythrocytes in high glucose level

Yang W.

Aim: The erythrocyte membrane lesion is a serious diabetic complication. Although most available data demonstrated by earlier studies that n-3 fatty acid was a potent agent in this complication of diabetes. Realization about protection effects of flaxseed oil on antioxidative capacity and against to membrane deformation of human peripheral blood erythrocytes in high glucose model is limited.Main methods: In this study, erythrocytes were treated with 50 m...

ea0026pl5 | Endocrine hypertension | ECE2011

Endocrine hypertension

Young W

Objective: To review the first reported cases of successfully treated pheochromocytoma and primary aldosteronism and document the diagnostic and therapeutic advances that have occurred since the initial descriptions.Methods: The original case descriptions and the subsequent pertinent literature were reviewed.Results: The successful management of the initial cases of pheochromocytoma in 1926 and primary aldosteronism in 1954 was hig...

ea0026mte6 | (1) | ECE2011

Difficult adrenal cases

Young W

Objective: To present 2 difficult adrenal cases in an interactive computer-based CPC format.Methods: The history of present illness will be presented for 2 patients: i) A 24-year-old woman who is 13 weeks pregnant presenting with spells and marked hypertension; ii) A 56-year-old man with hypertension, hypokalemia, and renal insufficiency. For the details of these cases, please see the Meet-the-expert handbook.Results: The attendees...