Searchable abstracts of presentations at key conferences in endocrinology

ea0090p478 | Thyroid | ECE2023

Mouse model of Graves’ ophthalmopathy induced by the immunization with TSHR A and IGF-1Rα subunit gene

Zheng Wei , Wu Ruixin , Li Ning , Wang Xuan , Wang Shen , Tan Jian

Background: The study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ ophthalmopathy (GO; GD+GO) that can represent the clinical disease characteristics.Methods: A eukaryotic expression plasmid of insulin-like growth factor 1 receptor (IGF-1R) α subunit (pcDNA3.1/IGF-1Rα) and a thyrotropin receptor (TSHR) A subunit plasmid (pcDNA3.1/TSHR-289) were injected in female BALB/c mice to induce a GD+GO model. Grouping w...

ea0081ep1020 | Thyroid | ECE2022

Male was not a prognostic risk factor in postoperative DTC patients treated with 131I treatment: a propensity score-matching study

Zheng Wei , Zhou Yaqian , Wang Shen , Wang Xuan , Tan Jian

Objective: Propensity score matching (PSM) was used to study whether male patients with differentiated thyroid cancer (DTC) were the risk factors for prognosis after 131I treatment.Methods: 1677 patients with DTC who underwent total thyroidectomy and received 131I treatment were divided into male group (n= 546) and female group (n= 1131). The PSM method was adopted to process all the data to reduce the influence of...

ea0090p654 | Endocrine-related Cancer | ECE2023

Intermediate-risk Differentiated Thyroid Cancer with Stimulated Thyroglobulin or N1b Needs High Adjuvant Radioactive Iodine Dose

Li Xue , Zheng Wei , Ji Yanhui , Sun Danyang , Wang Xuan

Background: There are no definite recommendations on the optimal dosage of initiating adjuvant radioactive iodine (RAI) therapy for intermediate-risk differentiated thyroid cancer (DTC) patients in current relevant guideline. This study aimed to investigate the response of intermediate-risk DTC patients with a low (3.7GBq) or high RAI dose (5.55GBq).Methods: Propensity score matching was performed to control for baseline characteristics. A total of 476 p...

ea0090p225 | Thyroid | ECE2023

Clinical Characteristics of Differentiated Thyroid Carcinoma with Obesity and Glucose Metabolism

Wang Xuan , Zheng Wei , Li Xue , Sun Danyang , Ji Yanhui

Objective: To explore the association between body mass index (BMI) and plasma glucose level with pathological features and clinical outcomes of differentiated thyroid cancer (DTC).Methods: Clinical data of 1264 consecutive DTC patients treated with total thyroidectomy and enrolled at the time of the first 131I treatment from April 2016 to July 2020. The clinicopathological findings were compared in the groups were categorized according to BMI...

ea0090p216 | Thyroid | ECE2023

UPLC-Q-TOF/MS-based metabolomics explored the metabolic mechanisms of thyroid cancer in different background

Sun Danyang , Li Xue , Wang Xuan , Ji Yanhui , Meng Zhaowei , Zheng Wei

Thyroid papillary carcinoma (PTC) is the most common endocrine tumor, Hashimoto’s thyroiditis (HT) is considered to be closely related to PTC pathogenesis, but their relationship still needs verification and exploration. Aim of the study. To analyze the differences and similarities of the metabolic mechanism of thyroid papillary carcinoma in normal and HT background, and to explore the relationship between HT and PTC. The Ultra performance liquid chromatography-q...

ea0073oc10.4 | Oral Communications 10: Thyroid | ECE2021

Targeting TSHR and ICAM-1 for treatment of Graves’ disease in BALB/c mice

Zheng Wei , Wang Xuan , Li Wang , Wang Shen , Tan Jian , Jia Qiang , Meng Zhaowei , Rui Zhongying

ObjectiveIn BALB/c mice with GD model, the TSHR and ICAM-1 were targeted for treatment, and new approaches to GD targeted therapy were explored.MethodsThe siRNA targeting TSHR and the ICAM-1 mAb specifically binding ICAM-1 were designed and synthesized. Thirty GD model mice were randomly divided into siRNA treatment group, ICAM-1 mAb treatment group, and untreated GD group, with 10 mice in each group, and 10 ...