Searchable abstracts of presentations at key conferences in endocrinology

ea0016p201 | Diabetes and cardiovascular diseases | ECE2008

No genetic impact of the SOCS3-gene on T2DM

Fischer Antje , Fisher Eva , Moehlig Matthias , Osterhoff Martin , Weickert Martin O , Pfeifer Andreas FH , Boeing Heiner , Spranger Joachim

The diabetic epidemic is increasing worldwide. The suppressor of cytokine signaling 3 (SOCS3) provides a link between cytokine action and their negative consequences on insulin signaling. This potential influence on the development of T2DM makes the gene a potential candidate gene for type 2 diabetes.We investigated the one haplotype tagging single nucleotide polymorphism (htSNP) rs4969168 to examine the impact on T2DM in two independent study population...

ea0055cb5 | Additional Cases | SFEEU2018

Post-operative hypocalcaemia in a patient with a metastatic pancreatic neuroendocrine tumour

Sukumar Nithya , Kaltsas Gregory , Weickert Martin

Case history: Mrs SC, a 56 year old female was referred to the endocrine registrar with hypocalcaemia (corrected calcium 1.93 mmol/l). She was day 3 post-hemihepatectomy for liver metastases from a primary pancreatic tail neuroendocrine tumour (NET). She had paraesthesia and numbness of her fingers and toes but no spasms. Chvostek’s sign was negative and there were no ECG changes. Past medical history includes severe hypercalcaemia in September 2016 which...

ea0077p161 | Bone and Calcium | SFEBES2021

Autoimmune Polyglandular syndrome presenting with multiple Endocrinopathies

Awala Orighomisan , Machenahalli Pratiba , Sankar Sailesh , Randeeva Harpal , Weickert Martin

Background: Autoimmune polyglandular syndrome type 1 (APS-1) is an autoimmune inherited disorder, a potentially underdiagnosed clinical entity, caused by mutations in the autoimmune regulatory gene that can present with varying symptomatology as it affects various organs, posing both a diagnostic and management hurdle. We report a case to highlight this complexity.Case report: Case details involves a female who first presented in childhood with rash, eye...

ea0022p142 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Insulin mediates the glucagon-induced decrease in atrial natriuretic peptide: a randomized controlled trial

Arafat Ayman , Rudovich Natalia , Adamidou Aikaterini , Spranger Joachim , Weickert Martin , Mohlig Matthias , Pfeiffer Andreas

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients suffering from metabolic syndrome hypertension, hyperinsulinemia and postprandial hyperglucagonemia are common features. It was the aim of the present study to evaluate the impact of glucagon on proANP and the possible mechanisms ...

ea0022p687 | Obesity | ECE2010

Glucagon stimulates cholecystokinin secretion in humans

Arafat Ayman , Otto Barbel , Adamidou Aikaterini , Spranger Joachim , Weickert Martin , Mohlig Matthias , Pfeiffer Andreas

Objectives: Gastrointestinal hormones are known to modulate satiety. The mechanisms underlying the impact of glucagon on satiety are so far unknown. However, it can be postulated that the glucagon-induced reduction in hunger feeling is mediated through changes in Cholecystokinin (CCK), which is known to play a role in meal termination. It was the aim of the present study to evaluate the impact of glucagon on CCK and the modulation of these effects in obesity.<p class="abst...

ea0021p93 | Clinical practice/governance and case reports | SFEBES2009

Reasons for treatment changes in hypogonadal men undergoing testosterone replacement

Dutton David , Outterside Kate , Padinjakara Rayin , Weickert Martin , Randeva Harpal , Sankar Sailesh

Aims: Treatment regimes for low testosterone are well established but reasons for treatment change and patient preferences are less well known. We looked at the type of testosterone replacement, subsequent modification of replacement and reason for that change.Methods: Data were collected from the electronic case notes of 50 patients on testosterone replacement for at least 6 months attending endocrine clinics in a University Teaching Hospital.<p cla...

ea0021p199 | Endocrine tumours and neoplasia | SFEBES2009

Cinacalcet treatment of resistant hypercalcaemia due to MEN1-associated primary hyperparathyroidism in pregnancy

Wysota Barbara , Horne Stephanie , Smyth Angharad , Anwar Aresh , Sankar Sailesh , Weickert Martin

Cinacalcet increases sensitivity of the calcium sensing-receptor, currently licenced for treatment of refractory secondary hyperparathyroidism in patients with end-stage renal disease. It decreases parathyroid hormone, calcium and phosphorus levels. There is no clinical data for the use of Cinacalcet in pregnancy. Hyperparathyroidism is rare during pregnancy, mainly presenting early, when surgery is safely performed. Here we report a patient presenting with a MEN1-associated p...

ea0086p260 | Neuroendocrinology and Pituitary | SFEBES2022

Cushing’s Syndrome – A medical emergency and diagnostic challenge

Thadani Puja , Chaudhury Nadia , Murthy Narasimha , Rao Ranganatha , Randeva Harpal , Weickert Martin , Gholap Nitin

Background: Ectopic Cushing’s syndrome (ECS) is a rare and severe condition at times presenting acutely with intense hypercortisolism. The intensity of hypercortisolism can be disproportionate to underlying tumoral condition, and associated life-threatening complications are common arising suddenly. Hypercortisolism must be controlled rapidly pending definitive treatment of tumoral source to avoid life-threatening consequences.Case Summary: 31-year-...

ea0059p162 | Obesity &amp; metabolism | SFEBES2018

The relationship between obstructive sleep apnoea and quality of life in women with polycystic ovary syndrome: a cross-sectional study

Kahal Hassan , Tahrani Abd , Kyrou Ioannis , Dimitriadis Georgios , Kimani Peter , Barber Thomas , Nicholls Matthew , Ali Asad , Weickert Martin , Randeva Harpal

Background: Obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS) are associated with significant comorbidities and commonly coexist. The primary aim of this study was to examine the relationship between OSA and quality of life (QoL) in women with PCOS.Study design: Observational cross-sectional study.Methods: Women with PCOS were recruited from a single secondary care centre in the UK. PCOS was diagnosed according to...

ea0022p713 | Obesity | ECE2010

Gastric inhibitory polypeptide (GIP) suppresses circulating ghrelin in humans: plasma metabolome based correlation network analysis for support of hormone-to- hormone interactions

Rudovich Natalia , Nikiforova Victoria J , Otto Baerbel , Pivovarova Olga , Gogebakan Ozlem , Weickert Martin O , Nauck Michael A , Pfeiffer Andreas F H

Aims: We investigate the influence of GIP on ghrelin secretion in normal glucose tolerant individuals with the use of the firstly applied correlation network analysis on human plasma metabolome data.Methods: To address this issue, we employed a GIP-infusion test and euglycemic- and hyperglycemic glucose clamp experiments combined with infusion of GIP or placebo in a cross-over manner in non diabetic obese male subjects (n=14). Moreover, we firstly...