Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep775 | Pituitary: clinical | ECE2015

Congenital pituitary stalk interruption syndrome with isolated GH and TSH deficiency and Rathke's cleft cyst: an incidental association

Wessling Ana , Paixao Raquel , Aragues Jose Maria , Mascarenhas Mario

Introduction: Congenital pituitary stalk interruption syndrome (PSIS) is a rare condition, characterized by the triad (not always complete): absence/hypoplasia of the pituitary stalk, hypoplasia/aplasia of the anterior pituitary and absence or ectopy of the posterior pituitary high signal intensity, on magnetic resonance imaging (MRI). PSIS implies a permanent GH deficiency, in 77% associated with other pituitary hormones deficiencies. The aetiology remains uncertain, but some...

ea0035p350 | Diabetes (epidemiology, pathophysiology) | ECE2014

Clinical case of type 1 diabetes mellitus and multiple sclerosis – just bad luck?

Wessling Ana , Aragues Jose Maria , Guerra Silvia , Mascarenhas Mario

Introduction: Type 1 diabetes mellitus (T1DM) and multiple sclerosis (MS) are organ-specific autoimmune diseases. Their association, first described in a study in Sardinia, left questions about their clustering, clarified by the Familial Autoimmune and Diabetes Study, which showed for the first time an highly increased prevalence of MS in adults with T1DM, reinforced by further epidemiological studies that also revealed increased risk of T1DM in MS patients.<p class="abste...

ea0032p318 | Clinical case reports - Thyroid / Others | ECE2013

Never too late to discover some extra thyroid tissue

Wessling Ana , Araguez Jose Maria , Ferreira Florbela , Carmo Isabel

Introduction: Ectopic thyroid is a rare entity, resulting from developmental defects at early stages of thyroid embriogenesis. It’s prevalence is 1/100 000–300 000 in general population and 1/4000–8000 in patients with thyroid disease. This condition is more common in females, in Asians and may occur at any age, although it’s most common at younger ages. The most frequent location of ectopic thyroid tissue is at the base of the tongue. In 70–75% of cas...

ea0032p556 | Endocrine tumours and neoplasia | ECE2013

Acromegaly, primary hyperparathyroidism and meningioma – an unsual association in an asymptomatic patient with MEN1 syndrome

Ferreira Florbela , Nobre Ema , Wessling Ana , Carmo Isabel

Introduction: MEN1 is inherited as an autosomal dominant trait, with a prevalence of 2–20/100 000 in the general population. It is characterized by tumors envolving the parathyroid glands, the endocrine pancreas and the pituitary. Other tumors are more rarely associated: adrenal adenomas, carcinoid tumors, pheocromocytomas, angiofibromas, lipomas, collagenomas and meningiomas. The presence of two or more of MEN1 associated tumors is diagnostic of the syndrome.<p class...

ea0056p810 | Pituitary - Clinical | ECE2018

Male hypogonadism – when two endocrine causes merge in the same patient

Araujo Alexandra Novais , Wessling Ana , Bugalho Maria Joao

Introduction: Male hypogonadism is defined by lower levels of testosterone than expected for age-matched individuals. In primary or hypergonadotropic hypogonadism, LH and FSH show a compensatory elevation to low testosterone levels, while in the secondary or hypogonadotropic hypogonadism the low testosterone levels are a result of insufficient gonadotropin levels. Hyperprolactinemia is a cause of hypogonadotropic hypogonadism. It is not only caused by lactotroph adenomas (prol...

ea0049ep300 | Calcium &amp; Vitamin D metabolism | ECE2017

The importance of ultrasound in the preoperative evaluation of patients with primary hyperthyroidism: a case report

Marcalo Jose , Araujo Alexandra , Wessling Ana , Carvalho Maria Raquel , Bugalho Maria Joao

Introduction: Primary hyperparathyroidism is the most common cause of hypercalcemia in the outpatient setting, and a single parathyroid adenoma is usually the culprit. Clinical presentation is commonly dictated by hypercalcemia. Symptoms can range from mild non-specific malaise and gastrointestinal disturbances, through bone disease, kidney stones, cardiovascular and neuromuscular dysfunction to, ultimately, coma and death. However, the vast majority of patien...

ea0049ep1055 | Pituitary - Clinical | ECE2017

Hypogonadotropic hypogonadism in a patient with long-term primary hypothyroidism

Vaz de Castro Raquel , Maria Aragues Jose , Ferreira Florbela , Gomes Vania , Wessling Ana , Joao Bugalho Maria

Abstract: We report the case of a 65-year-old man who presented with erectile dysfunction to an appointment in our Endocrinology department. He referred fatigue, weight gain and constipation as secondary complaints that had been steadily evolving throughout the past 4 years. He denied other symptoms such as visual impairment or headaches as well as the consumption of any medications or drugs. His past medical history was unremarkable. On examination, BMI was 25.8 kg/m2</s...

ea0049ep1255 | Thyroid (non-cancer) | ECE2017

Postpartum thyrotoxicosis – a diagnosis, sometimes, postponed

Araujo Alexandra Novais , Marcalo Jose , Costa Cristiana , Wessling Ana , Bugalho Maria Joao

Postpartum thyroid dysfunction occurs in 5–10% of women in the general population within one year of delivery. The prevalence of postpartum Graves’ disease is estimated at 0.54%. Postpartum thyroiditis is much more common. Differential diagnosis is essential for an adequate treatment. Radioactive iodine uptake can be useful to establish the etiologic diagnosis, but is contraindicated during lactation. Elevated titers of antithyrotropin receptor antibodies (TRAbs) are...

ea0049ep1340 | Thyroid (non-cancer) | ECE2017

Peripheral neuropathy in hypothyroidism - about a clinical case

Marcalo Jose , Araujo Alexandra , Faria Carolina , Wessling Ana , Carvalho Maria Raquel , Nobre Ema , Bugalho Maria Joao

Introduction: Hypothyroidism can affect the nervous system, commonly causing mono and polyneuropathies which show a variable frequency and pattern. Its mechanisms are not fully understood. Symptoms usually correlate better with the duration of the dysfunction rather than with its severity and typically improve significantly after medical therapy.Case report: A 58-year-old woman was admitted at our hospital with a one-year history of progressive weakness ...

ea0032p1124 | Thyroid cancer | ECE2013

A rare case of nonsecretory medullary thyroid carcinoma

Ferreira Florbela , Marcelino Mafalda , Wessling Ana , Nobre Ema , Leite Valeriano , Carmo Isabel

Introduction: Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer, making up about 3–5% of all cases. It is characterized by the synthesis and secretion of calcitonin (Ct). Measurement of Ct has low specificity but is a highly sensitive method for the detection of MTC. MTC with normal or only slightly elevated Ct is a rare occurrence and there are few such reports in the literature.Case report: A 61-year-old male patient was referred ...