Endocrine Abstracts

Cushing Syndrome (CS) is associated with a 18-fold higher risk of venous thromboembolism (VTE) when compared to the general population with the similar demographic characteristics. Despite numerous studies on hypercoagulability in CS, the unequivocal recommendations regarding timing and dosing of thromboprophylaxis in hypercortisolism are still lacking. We present a case series of patients with CS and VTE, hospitalized in the Endocrinology Department of University Hospital in ...

Introduction: Thoracic Endometriosis Syndrome (TES) is characterized by clinical symptoms associated with menstruation (eg, catamenial pneumothorax (CP), chest pain, and others) not obligatorily requiring histological confirmation. The treatment is burdened with frequent recurrences. This study aimed to characterize the treatment of women with TES and assess the concomitant diseases.Methods: A developed online survey was published in patients’ suppo...

The spectrum of lesions in the sellar and parasellar region includes a wide range of diseases, from the most common adenoma to various non-adenomatous lesions i.a. empty sella syndrome, stroke and congenital conditions. We identified a case of meningitis in which the images initially suggested the presence of a pituitary macroadenoma. The 45-year-old patient without chronic diseases was admitted to the Department of Neurology due to severe headaches and vomiting that had woken...

Metastatic involvement of the pituitary gland is a rare phenomenon with various clinical and radiological manifestations, but it is clinically important and requires appropriate and early diagnosis. The posterior lobe of the pituitary gland is more often involved, so we expect that AVP deficiency would be the most common clinical manifestation of pituitary metastasis. Presentation without involvement of the posterior lobe, without AVP deficiency and with anterior lobe hypofunc...

Chordomas of the skull base are rare lesions, which account for less than 0.2% of all intracranial tumours. They arise from embryonic remnants of the primitive notochord. They are described as locally aggressive, rarely metastatic tumours with a tendency to frequent relapses. They usually grow slowly with the destruction of the surrounding tissues. The symptoms are very unspecific which is the cause of the delay of the diagnosis. The most common initial symptoms are headaches ...

Introduction: According to the results of several studies and meta-analyses, certain ultrasound features are associated with increased risk of thyroid malignancy. However, most of those research papers included mainly papillary thyroid cancers (PTCs); these results cannot be simply extrapolated for the differentiation of follicular thyroid adenomas and cancers (FTAs and FTCs). The aim of the present study was to perform a meta-analysis of so far conducted research and identify...

Introduction: Idiopathic granulomatous hypophysitis (IGH) is a rare inflammatory disease that may present with radiological changes in the pituitary gland. Diagnosis with non-specific syndromes becomes challenging. Secondary causes of granulomatous hypophysitis include tuberculosis, sarcoidosis, syphilis, Langerhans cell histiocytosis, GPA, and Rathke’s cleft cyst rupture. GPA is a multisystem disease, characterized by necrotizing small-vessel vasculitis, mostly affecting...

Malignant pheochromocytomas (MP) are rare form of catecholamine-producing tumours that are usually associated with tachycardia, hypertension and diaphoresis. MP are typically diagnosed by symptoms, elevated catecholamine levels and characteristic radiological imagining. Metastases to the vertebrae are extremely rare and usually appear at late stage of the disease, sometimes years after the diagnosis. Backpain as a first manifestation of MP is unusual, especially with history o...

Introduction: AVP secretion disturbances in pituitary lesions usuall, present as AVP deficienc, due to compression of the posterior pituitary lobe. Excessive secretion of AVP (syndrome of inappropriate antidiuresis) (SIAD) is ver, uncommon in patients with pituitary tumor. A few cases of non-functionating adenoma, prolactinoma, and even pituitary apoplex, were described to present with SIAD. Pituicytoma is a rare tumor of the neurohypophysis. The, usuall, present with visual d...

Objective: The thyroid fine needle aspiration biopsy (FNAB) may bring inconclusive cytological results of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) or follicular neoplasm/suspicious for follicular neoplasm (FN/SFN). The objective of the study was to describe the genetic landscape of indeterminate thyroid nodules to better understand this phenomenon and identify genetic markers potentially differentiating benign and malignant ...