Searchable abstracts of presentations at key conferences in endocrinology

ea0044cc8 | Featured Clinical Cases | SFEBES2016

Diffuse Idiopathic Pulmonary Neuroendocrine cell hyperplasia (DIPNECH): two unusual cases of cyclical ectopic adrenocorticotrophic hormone secretion

Ali Sarah N , Moriarty Maura , Yang Lisa , Anderson Jonathan , Todd Jeannie F

We present two uncommon cases of cyclical ectopic ACTH-dependent Cushing’s syndrome due to diffuse idiopathic pulmonary neuroendocrine tumour (DIPNECH).Case 1: 62 yr lady presented with rapid onset of muscle weakness, diabetes and hypokalaemia. Random cortisol:1710 nmol/l, ACTH level:610 ng/l. LDDST: failure to suppress cortisol levels. Imaging: normal pituitary gland and bilateral adrenal hyperplasia, consistent with ACTH dependent Cushing’s s...

ea0034p180 | Neoplasia, cancer and late effects | SFEBES2014

Characteristics of ‘foregut’ carcinoid tumours occurring in multiple endocrine neoplasia type 1

Yang Lisa , Mann Kirsty , Winceslaus Julian , Khan Roaid , Akker Scott , Waterhouse Mona , Drake William , Druce Maralyn

Background: The glands most commonly affected in MEN1 are parathyroid, pituitary and pancreas. Pancreatic neuroendocrine tumours (pNETs) are of foregut origin, but a number of other so-called ’foregut carcinoid tumours’ may also occur in MEN1, including tumours of bronchial, thymic, and gastrointestinal origin. Reported rates of prevalence of these latter tumours vary from 2% for thymic and bronchial carcinoids, to 10% for gastric carcinoids. Thymic carcinoids have b...

ea0048o6 | Oral Communications | SFEEU2017

Using Kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea

Narayanaswamy Shakunthala , Vimalesvaran Sunitha , Yang Lisa , Prague Julia K , Miras Alexander D , Franks Stephen , Meeran Karim , Dhillo Waljit S

Case history: An 18-year-old Caucasian female presented with primary amenorrhoea after her younger sister aged 16 years old started menstruating. She had a normal childhood and progressed through puberty normally, with no past medical history or family history. BMI was 22.6 with a normal examination including secondary sexual characteristics (Tanner Stage 5) and no signs of hyperandrogenism.Investigations and Results: Bloods showed an elevated LH:FSH rat...

ea0065oc6.6 | Reproductive Endocrinology and Biology | SFEBES2019

Kisspeptin enhances the brain processing of attraction in men

Yang Lisa , Demetriou Lysia , Wall Matt , Mills Edouard , Zargaran David , Sykes Mark , Prague Julia , Abbara Ali , Owen Bryn , Bassett Paul , Rabiner Eugenii , Comninos Alexander , Dhillo Waljit

Background: Successful reproduction relies on integration of sensory cues of attraction with corresponding emotions and behaviours. However, the intrinsic factors integrating these fundamental aspects of human attraction with limbic and reproductive pathways have not been fully identified. Kisspeptin is a crucial activator of the reproductive axis and together with its receptor is widely expressed throughout the limbic and olfactory systems in humans suggesting a potential rol...

ea0077oc1.4 | Reproductive and Neuroendocrinology | SFEBES2021

Intranasal Kisspeptin Administration Stimulates Reproductive Hormone Secretion in Healthy Men

Mills Edouard G , Swedrowska Magda , Thurston Layla , Phylactou Maria , Patel Bijal , Clarke Sophie A , Yang Lisa , Muzi Beatrice , Choudhry Muhammad , Alexander Emma , Abbara Ali , Forbes Ben , Comninos Alexander N , Dhillo Waljit S

Background: Kisspeptin is a critical activator of hypothalamic gonadotrophin-releasing hormone neurons, inducing release of downstream reproductive hormones. Intravenous or subcutaneous kisspeptin administration has been shown to have significant potential to treat reproductive disorders. However, intranasal administration could offer a novel non-invasive delivery route, which would be clinically preferable. We therefore sought to determine the effects of intranasal kisspeptin...

ea0081oc7.2 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Kisspeptin administration has therapeutic potential for men with low sexual desire by increasing penile tumescence and sexual brain processing

Mills Edouard , Ertl Natalie , Wall Matt B , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Muzi Beatrice , Ettehad Dena , Howard Jonathan , Rabiner Eugenii A , Bech Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Background: Hypoactive Sexual Desire Disorder (HSDD) is associated with dysfunctional brain activation in regions governing sexual responses, resulting in a deficiency/absence of sexual desire with marked distress. It affects up to 8% of men with detrimental effects on quality of life, interpersonal relationships and fertility, but so far has no licensed treatment options. The reproductive neuropeptide kisspeptin offers a putative therapeutic target owing to its emerging role ...

ea0081p183 | Reproductive and Developmental Endocrinology | ECE2022

Intranasal kisspeptin administration stimulates reproductive hormone secretion in healthy volunteers and patients with hypogonadism

Mills Edouard , Swedrowska Magda , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie , Muzi Beatrice , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Forbes Ben , Comninos Alexander , Dhillo Waljit

Background: Kisspeptin is a critical activator of hypothalamic gonadotrophin releasing hormone (GnRH) neurons and has significant potential to treat common reproductive disorders. To date, kisspeptin has solely been administered to humans via the intravenous or subcutaneous routes, however intranasal administration could offer a novel non-invasive delivery route. We therefore sought to determine the effects of intranasal kisspeptin on reproductive hormone release in humans for...

ea0065op5.4 | Reproductive Endocrinology and Biology | SFEBES2019

Kisspeptin as a novel biomarker for pregnancy complications

Phylactou Maria , Abbara Ali , Al-Memar Maya , Eng Pei Chia , Comninos Alexander N , Izzi-Engbeaya Chioma , Clarke Sophie A , Mills Edouard , Nadir Rans , Sykes Mark , Pacuszka Ewa , Yang Lisa , Fourie Hanine , Bech Paul , Kelsey Tom W , Bourne Tom , Dhillo Waljit S

Background: Placentation (invasion of the placenta into the maternal endometrium) is hypothesised to be critical for healthy placental function and is abnormal in two thirds of miscarriages. Kisspeptin has emerged as a putative regulator of physiological placentation; it is highly expressed in placental syncytiotrophoblasts and could play an important paracrine role in the regulation of placentation. Circulating kisspeptin levels are considerably raised during healthy pregnanc...

ea0065p350 | Reproductive Endocrinology and Biology | SFEBES2019

Gonadotrophin rise following the kisspeptin analogue (MVT-602) is increased in women with hypothalamic amenorrhoea compared to healthy women

Eng Pei Chia , Abbara Ali , Phylactou Maria , Clarke Sophie A , Yang Lisa , Mills Edouard , Modi Manish , Papadopoulou Deborah , Plumptre Isabella , Hunjan Tia , Purugganan Kate , Webber Lisa , Salim Rehan , Comninos Alexander N , Dhillo Waljit S

Introduction: Hypothalamic amenorrhoea (HA) is a condition characterised by reduced GnRH pulsatility and is a common cause of anovulatory subfertility. Kisspeptin is an endogenous neuropeptide that regulates hypothalamic GnRH function. Hypothalamic kisspeptin expression is reduced, and kisspeptin receptor expression is increased, in a rodent model of HA. The kisspeptin analogue MVT-602 has a 3-4-fold longer half-life than native kisspeptin-54 (t1/2 0.5 h). We invest...

ea0059oc4.2 | Clinical highlights | SFEBES2018

Kisspeptin- a novel clinical test of hypothalamic function in men with hypogonadotrophic hypogonadism

Chia Eng Pei , Abbara Sophie Clarke Ali , Phylactou Maria , Mills Edouard , Koteshwara Muralidhara , Chia Germaine , Yang Lisa , Pratibha Machenahalli C , Papadopoulou Deborah , Izzy-Engbeaya Chioma , Jayasena Channa , Comninos Alexander N , Dhillo Waljit S

Background: Hypogonadotrophic Hypogonadism (HH) is characterised by hypogonadism in the context of low gonadotrophin levels, frequently due to a defect in hypothalamic function e.g. Kallman’s syndrome. However, no direct test of hypothalamic function currently exists. Kisspeptin is a hypothalamic neuropeptide that stimulates endogenous GnRH release. Thus, we investigated whether kisspeptin could be used to interrogate hypothalamic function in men with HH.<p class="abs...