Endocrine Abstracts

Background: Vitamin D deficiency is frequently associated with primary hyperparathyroidism, but the impact of this association on disease evolution and complications is ill defined. Aims: to assess the role of vitamin D status on the metabolic profile and spectrum of complications at patients with primary hyperparathyroidism.Materials and methods: Transversal study involving 42 patients with primary hyperparathyroidism submitted to parathyroidectomy. We ...

Background: D hypovitaminosis and primary hyperparathyroidism frequently coexist. Secondary hyperparathyroidism reactive to D hypovitaminosis is difficult to be differentiated from primary hyperparthyroidism.Aims: To differentiate patients with D hypovitaminosis and secondary hyperparathyroidism.Materials and methods: Prospective study involving 71 patients admitted in our department for 1 year with the initial diagnosis of primary...

Introduction: Obesity and insulin resistance have been identified as risk factors for breast cancer and are associated with late-stage diagnosis and poor prognosis. Ghrelin is a unique gut-derived peptide that has major impact in energy homeostasis and weight regulation, with new emerging implications in tumorigenesis process, especially in hormone-dependent cancers.Aim: To evaluate the relationship between ghrelin, clinico-biological parameters of obesi...

Aim: Fibroblast growth factor-23 (FGF-23) has been proposed as a predictor of bone abnormalities in chronic kidney disease patients (CKD), with recent data showing that it may also predict bone mass in the general population. We aimed at investigating the relationship between FGF-23 and bone mass parameters in apparently healthy individuals, according to sex, menopausal and nutritional status.Materials and methods: Bone mass (bone mineral density-BMD, bo...

Introduction: Body weight and lean mass (LM) are classic bone mass determinants. However, the association between total fat mass (FM), regional FM and bone remains controversial, especially as fat is a source of adipocytokines, with both positive and negative bone consequences.Materials and methods: Anthropometric, bone mass (assessed by Dual X-Ray Absorptiometry; DXA) and body composition parameters (assessed by DXA) and also serum adipocytokine (leptin...

Introduction: Despite the high burden of osteoporotic fractures, bone evaluation in men is not without flaws, being frequently undervalued. We aimed at investigating the role of body composition, adipokines and classic bone determinants (sex hormones) as predictive factors for bone mass parameters in healthy young and middle-aged men.Materials and methods: Anthropometric, bone mineral density (BMD) (assessed by Dual X-Ray Absorptiometry;DXA) and body com...