Endocrine Abstracts

Introduction: Hypothyroidism is considered refractory to oral levothyroxine substitution, when there is biochemical (serum level of TSH (thyroid stimulating hormone) above the upper target level) or clinical evidence of hypothyroidism, despite increasing dosages of oral levothyroxine beyond 2.5 μg/kg daily. In these circumstances, further increments in the dosage of levothyroxine may not always be the most appropriate intervention. In such a situation, physicians need to ...

Introduction: Hypopituitarism due to Sheehan′s syndrome is a rare complication and its diagnosis is often overlooked. The vast majority of people with hypothyroidism have primary hypothyroidism, often due to Hashimoto’s thyroiditis. Coexistence of hypopituitarism and primary hypothyroidism, may accelerate clinical manifestations, mainly those associated with hypothyroidism. Hashimoto′s Thyroiditis with concomitant hypopituitarism is rare but has been described...

Introduction: Hyponatremia is a common electrolyte disturbance in clinical practice, and is considered severe when Na+<125 mEq/L. In most patients, is caused by a single cause but, in selected cases, there are multiple factors that contribute together. Drugs are a common cause of electrolytes abnormalities and a careful drug history is important especially the interaction between them.Case report: We report the case of a 60-year-old male patient who ...

Introduction: Thyroid physiology changes during pregnancy so the use of pregnancy-specific reference ranges for TSH and FT4 in order to adequately diagnose gestational thyroid disease is necessary. According to literature, in twin pregnancy, TSH can be in low levels during first trimester due to a much higher and more sustained peak of hCG (TSH-like activity of human chorionic gonadotropin) but it will be normalized at the end of the second trimester or within 22 weeks. Hypere...