Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep1134 | Thyroid | ECE2022

Severe hyperthyreosis

Petrak Iva , Zibar Tomšić Karin

A 72-year-old male patient presented to the ER because of general weakness, myalgia, frequent paroxysms of atrial fibrillation, shortness of breath, and hoarseness. The symptoms persisted for two months, gradually worsening and causing him to lose weight. At some point, he noticed redness of the sclera and soreness of the eyeballs. Paroxysms of rapid atrial fibrillation have been known for more than 15 years, so he had amiodarone in therapy. His initial laboratory findings sho...

ea0099ep234 | Adrenal and Cardiovascular Endocrinology | ECE2024

The effect of adrenalectomy on metabolic parameters in patients with primary aldosteronism

Zibar Tomšić Karin , Đukić Mirjana , Solak Mirsala , Kaštelan Darko

Background: A few studies have shown that aldosterone has negative impact on metabolic parameters.Objectives: The aim of the study was to evaluate metabolic parameters in patients with primary aldosteronism (PA) before and one year after adrenalectomy.Methods: In this retrospective study, we examined 51 patients (median age 50 years, IQR 43–55; 55% male) who underwent adrenalectomy for PA between 2016 and 2022. Patients with d...

ea0081ep927 | Reproductive and Developmental Endocrinology | ECE2022

Online education as effective medical training for young endocrinologist

Jambrović Martina , Nekic Anja Barac , Sambula Lana , Petrak Iva , Matas Nino , Zibar Tomšić Karin

Background: Learning through various online platforms is very common nowadays and its popularity has increased especially during the pandemic period. Nowadays, medical professionals are turning more than ever to online education through available online books, websites, and various online platforms. The aim of this study was to show that virtual training can improve the knowledge and confidence of young endocrinologists.Methods: The Croatian Section for ...

ea0099ep239 | Adrenal and Cardiovascular Endocrinology | ECE2024

Remission rate of primary aldosteronism after unilateral adrenalectomy

Đukić Mirjana , Zibar Tomšić Karin , Knežević Nikola , Kaštelan Darko

Background: The existing consensus for patients with primary aldosteronism (PA) after unilateral adrenalectomy recommends annual follow-up to rule out persistence or recurrence of the disease.Objectives: The aim of the study was to assess the remission rate in patients with PA ≥1 year after adrenalectomy.Methods: Of the 41 patients who underwent adrenalectomy for PA between 2016 and 2021, 24 had available follow-up data and w...

ea0081p264 | Adrenal and Cardiovascular Endocrinology | ECE2022

Mitotane side effects in the treatment of patients with adrenocortical carcinoma - a retrospective study

Barac Nekic Anja , Zibar Tomšić Karin , Sambula Lana , Matas Nino , Jambrović Martina , Petrak Iva , Dusek Tina , Kastelan Darko

Introduction: Mitotane is widely used to treat adrenocortical carcinoma (ACC) and remains the mainstay of treatment along with surgery. The aim of this study is to evaluate the adverse side effects of mitotane treatment.Materials and Methods: This retrospective study included 36 patients with ACC, ENSAT stage I- IV, who were treated with mitotane in an adjuvant or palliative setting. Patients with ENSAT stage IV who died within 6 months after surgery wer...

ea0081p694 | Pituitary and Neuroendocrinology | ECE2022

Radiological classification of craniopharyngioma based on its origin

Skoric Polovina Tanja , Ozretic David , Solak Mirsala , Kraljevic Ivana , Dusek Tina , Balasko Annemarie , Zibar Tomšić Karin , Kastelan Darko

Recognizing the site of origin of craniopharyngioma (CP) along the hypothalamus-pituitary axis according to pre-operative MR is helpful to understand its growth pattern in relation to hypothalamus, which is critical in the prediction of hypothalamic injury and planning of treatment. We retrospectively classified 29 CP according to MR pre-operative image study using modified classification of Tang et al. (Nature, 8:10215, 2018). According to its relation to pituitary s...

ea0081ep648 | Pituitary and Neuroendocrinology | ECE2022

Medical treatment of active acromegaly - the results from the Croatian Acromegaly Registry

Sambula Lana , Solak Mirsala , Kraljevic Ivana , Popovac Hrvoje , Polovina Tanja Skoric , Zibar Tomšić Karin , Dusek Tina , Balasko Annemarie , Kastelan Darko

Background: The aim of this study was to evaluate the outcomes of medical treatment in patients with active acromegaly.Material and Methods: We performed a retrospective analysis of 163 patients (101 female, age at diagnosis 47.2±13.4 years) treated between 1990 and 2020., of which 53 were on medical treatment (32.5%). Remission rate after pituitary surgery was 66.5% (n=105/158; 5 patients refused surgery). Patients who did not achieve remiss...

ea0090ep676 | Pituitary and Neuroendocrinology | ECE2023

Early postoperative growth hormone measurement as a predictor of surgical remission of acromegaly

Kraljevic Ivana , Kovač Diana , Solak Mirsala , Skoric Polovina Tanja , Zibar Tomšić Karin , Balasko Annemarie , Dusek Tina , Kastelan Darko

Purpose: To evaluate the value of early postoperative growth hormone (GH) as a predictor of surgical remission of acromegaly.Methods: We conducted a retrospective search through our database of patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma from 2011 to June 2022. Only patients who underwent the first pituitary surgery and had GH measurements on the fifth postoperative day were included. The surgical remission was defin...

ea0070aep42 | Adrenal and Cardiovascular Endocrinology | ECE2020

Prognostic value of Ki-67 and ENSAT stage on recurrence-free survival and overall survival in patients with adrenocortical carcinoma

Kraljevic Ivana , Knezevic Nikola , Kakrigi Luka , Kakarigi Marko , Dusek Tina , Solak Mirsala , Skoric Polovina Tanja , Balasko Annemarie , Zibar Tomšić Karin , Alduk Ana Marija , Kastelan Darko

Background: The adrenocortical carcinoma (ACC) is a rare malignancy with poor outcomes and overall survival of less than 40%. Different prognostic factors were evaluated in patients with ACC. We analyzed overall survival (OS) and recurrence-free survival (RFS) in patients with ACC depending on Ki-67 and ENSAT staging.Methods: We performed a retrospective study on 62 ACC patients treated at the Croatian Referral Center for adrenal gland disorders from 200...

ea0070aep717 | Pituitary and Neuroendocrinology | ECE2020

Natural course of incidentally found nonfunctioning pituitary macroadenoma

Dusek Tina , Kasnar Ana-Marija , Kraljevic Ivana , Skoric Polovina Tanja , Solak Mirsala , Balasko Annemarie , Zibar Tomšić Karin , Popovac Hrvoje , Ozretic David , Jovanovic Ivan , Kastelan Darko

Introduction: The widespread use of neuroimaging leads to the increased detection of asymptomatic pituitary adenomasnot causing significant mass effect. Their optimal management remains unclear.Aim of the study: To explore the natural course of incidentally found nonfunctioning pituitary macroadenomas.Patients and Methods: This was a longitudinal study that enrolled patients with clinically nonfunctioning pituitary macroadenomas wh...