Endocrine Abstracts

A 72-year-old male patient presented to the ER because of general weakness, myalgia, frequent paroxysms of atrial fibrillation, shortness of breath, and hoarseness. The symptoms persisted for two months, gradually worsening and causing him to lose weight. At some point, he noticed redness of the sclera and soreness of the eyeballs. Paroxysms of rapid atrial fibrillation have been known for more than 15 years, so he had amiodarone in therapy. His initial laboratory findings sho...

Background: A few studies have shown that aldosterone has negative impact on metabolic parameters.Objectives: The aim of the study was to evaluate metabolic parameters in patients with primary aldosteronism (PA) before and one year after adrenalectomy.Methods: In this retrospective study, we examined 51 patients (median age 50 years, IQR 43–55; 55% male) who underwent adrenalectomy for PA between 2016 and 2022. Patients with d...

Background: Learning through various online platforms is very common nowadays and its popularity has increased especially during the pandemic period. Nowadays, medical professionals are turning more than ever to online education through available online books, websites, and various online platforms. The aim of this study was to show that virtual training can improve the knowledge and confidence of young endocrinologists.Methods: The Croatian Section for ...

Background: The existing consensus for patients with primary aldosteronism (PA) after unilateral adrenalectomy recommends annual follow-up to rule out persistence or recurrence of the disease.Objectives: The aim of the study was to assess the remission rate in patients with PA ≥1 year after adrenalectomy.Methods: Of the 41 patients who underwent adrenalectomy for PA between 2016 and 2021, 24 had available follow-up data and w...

Introduction: Mitotane is widely used to treat adrenocortical carcinoma (ACC) and remains the mainstay of treatment along with surgery. The aim of this study is to evaluate the adverse side effects of mitotane treatment.Materials and Methods: This retrospective study included 36 patients with ACC, ENSAT stage I- IV, who were treated with mitotane in an adjuvant or palliative setting. Patients with ENSAT stage IV who died within 6 months after surgery wer...

Recognizing the site of origin of craniopharyngioma (CP) along the hypothalamus-pituitary axis according to pre-operative MR is helpful to understand its growth pattern in relation to hypothalamus, which is critical in the prediction of hypothalamic injury and planning of treatment. We retrospectively classified 29 CP according to MR pre-operative image study using modified classification of Tang et al. (Nature, 8:10215, 2018). According to its relation to pituitary s...

Background: The aim of this study was to evaluate the outcomes of medical treatment in patients with active acromegaly.Material and Methods: We performed a retrospective analysis of 163 patients (101 female, age at diagnosis 47.2±13.4 years) treated between 1990 and 2020., of which 53 were on medical treatment (32.5%). Remission rate after pituitary surgery was 66.5% (n=105/158; 5 patients refused surgery). Patients who did not achieve remiss...

Purpose: To evaluate the value of early postoperative growth hormone (GH) as a predictor of surgical remission of acromegaly.Methods: We conducted a retrospective search through our database of patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma from 2011 to June 2022. Only patients who underwent the first pituitary surgery and had GH measurements on the fifth postoperative day were included. The surgical remission was defin...

Background: The adrenocortical carcinoma (ACC) is a rare malignancy with poor outcomes and overall survival of less than 40%. Different prognostic factors were evaluated in patients with ACC. We analyzed overall survival (OS) and recurrence-free survival (RFS) in patients with ACC depending on Ki-67 and ENSAT staging.Methods: We performed a retrospective study on 62 ACC patients treated at the Croatian Referral Center for adrenal gland disorders from 200...

Introduction: The widespread use of neuroimaging leads to the increased detection of asymptomatic pituitary adenomasnot causing significant mass effect. Their optimal management remains unclear.Aim of the study: To explore the natural course of incidentally found nonfunctioning pituitary macroadenomas.Patients and Methods: This was a longitudinal study that enrolled patients with clinically nonfunctioning pituitary macroadenomas wh...