Searchable abstracts of presentations at key conferences in endocrinology

ea0078OC8.8 | Oral Communications 8 | BSPED2021

Barriers to uploading diabetes technology at home

van Boxel Elizabeth , Trevelyan Nicola

Background: Our department cares for 273 children with type 1 diabetes (T1DM). All T1DM patients are issued with an uploadable glucose meter from diagnosis. 101 patients (37%) use insulin pump therapy and 126 (46%) use a continuous glucose monitoring device. Anecdotally we noted many patients were not uploading their data prior to coming to clinic. This contributed to reduced patient flow through diabetes clinics and also to reduced patient and carer engagement with their diab...

ea0078p13 | Diabetes | BSPED2021

Increased diabetic ketoacidosis at presentation of type 1 diabetes mellitus – A result of the COVID-19 pandemic or longer-term increasing trend?

Moon Rebecca , van Boxel Elizabeth , Berg Elizabeth , Trevelyan Nicola

Background: Reports from several countries have suggested an increased incidence of diabetic ketoacidosis (DKA) at presentation of type 1 diabetes mellitus (T1DM) during the COVID-19 pandemic. Published data on this from the United Kingdom is sparse. We examined the frequency and severity of DKA at diagnosis of T1DM in children presenting to a university hospital during the first year of the pandemic in comparison to preceding years.Methods: In England, ...

ea0078p20 | Diabetes | BSPED2021

Does diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus affect anti tissue transglutaminase immunoglobulin A (tTG-IgA) levels?

Moon Rebecca , van Boxel Elizabeth , Berg Elizabeth , Trevelyan Nicola

Background: Current guidance recommends screening for coeliac disease (CD) at diagnosis of type 1 diabetes mellitus (T1DM) using measurement of serum anti tissue transglutaminase immunoglobulin A (tTG-IgA). It is recognized that tTG-IgA levels can fluctuate and there are reports of transient rises in tTG-IgA levels in response to acute stress, such as infection and acute coronary syndrome. The effect of diabetic ketoacidosis (DKA) on tTG-IgA has not been reported. We investiga...

ea0085p36 | Obesity 1 | BSPED2022

Percentage excess weight and risk of co-morbidity in obese children

van Boxel Elizabeth , Lokulo-Sodipe Oluwakemi , Jayne Kathryn , Davis Nikki

Background: One in four children in England are now obese by school year 6. Childhood obesity is associated with significant co-morbidity including type 2 diabetes (T2DM), non-alcoholic fatty liver disease (NAFLD), obstructive sleep apnoea (OSA) and depression. NICE guidance suggests consideration of co-morbidity screening in children with body mass index (BMI) >98th centile but BMI does not accurately reflect adiposity in children owing to confounding effects of gender, h...

ea0085p76 | Obesity 2 | BSPED2022

Semaglutide as a safe and effective weight loss treatment in children with obesity

van Boxel Elizabeth , Boulos Nabil , Jayne Kathryn , Reilly Joseph , Mayes Rebecca , Davis Nikki

Background: A quarter of UK children now leave primary school obese. Childhood obesity is associated with significant comorbidity including obstructive sleep apnoea, type 2 diabetes, non-alcoholic fatty liver disease, hypertension and depression. We report our experience of using semaglutide, a weekly subcutaneous GLP1 receptor agonist, as a weight-loss adjunct for severely obese children in combination with dietary and lifestyle support from a multidisciplinary team.<p cl...

ea0066oc5.10 | Oral Communications 5 | BSPED2019

Review of neonatal cortisol evaluation between 2012–2018 in a single centre: trends, outcomes and associations

Makaya Taffy , Sarvasiddhi Satish , van Boxel Elizabeth , Menon Smrithi , Shine Brian

Background: Neonatal cortisol assessment is indicated in suspected adrenal insufficiency.Aims/objectives: Review of neonatal cortisol assessment within our Trust over seven years, to analyse trends, indications, outcomes; and relationships between gestational age (GA), birth weight (BW) and cortisol assessment.Methodology: From cortisol results on neonates (≤30 days age) between 2012–2018 (inclusive) we identified random...