Searchable abstracts of presentations at key conferences in endocrinology

ea0007p146 | Neuroendocrinology and behaviour | BES2004

Cardiovascular risk burden in adult patients with hypopituitarism

Kyaw|#Tun T , Agha A , Muigai N , Al-Sahli W , Rogers B , Tormey W , Thompson C

Hypopituitarism is associated with premature vascular mortality. Growth hormone (GH) deficiency, over-replacement with glucocorticoid, cranial irradiation and traditional vascular risk factors are possible contributing factors to the excess mortality.We studied 200 consecutive adult hypopituitary age (mean standard deviation) 51.7 plus/minus 15.3 years, who attended our pituitary clinic between July and December 2002. Hypertension was defined as blood pr...

ea0007p148 | Neuroendocrinology and behaviour | BES2004

Neuroendocrine abnormalities in the acute phase of traumatic brain injury

Rogers B , Agha A , Mylotte D , Tormey W , Phillips J , Thompson C

Pituitary hormone abnormalities have been reported in up to 50% of survivors of traumatic brain injury (TBI), tested several months or longer after the event. No information is available on the frequency of hypopituitarism in the immediate post-TBI period.We studied 50 consecutive patients who were admitted to the neurosurgical unit with severe or moderate TBI [initial Glasgow Coma Scale (GCS) score 3-13]. Testing was performed at a median of 12 days pos...

ea0007p198 | Steroids | BES2004

Conventional corticosteroid replacement therapy may overtreat adult hypopituitary patients with partial ACTH deficiency

Agha A , Liew A , Finucane F , Baker L , O'Kelly P , Tormey W , Thompson C

Corticosteroid therapy is associated with potentially serious side effects, but there is no information available regarding glucocorticoid requirements in adult hypopituitary patients with partial adreno-corticotrophin hormone (ACTH) deficiency.10 male adult hypopituitary patients with partial ACTH deficiency, baseline plasma cortisol > 200 nanomole/ litre but a peak stimulated cortisol < 550 nanomole/ litre, were randomised to a cross-over protoco...

ea0056p811 | Pituitary - Clinical | ECE2018

The diagnostic utility of late night salivary cortisol (LNSF) and cortisone (LNSE) in Cushing’s Syndrome and their relationship to metabolic markers

Garrahy Aoife , Forde Hannah , O'Kelly Patrick , McGurren Karen , Tormey William , Smith Diarmuid , Javadpour Mohsen , Agha Amar

The diagnosis of Cushing’s Syndrome (CS) requires demonstration of excess circulating cortisol. Measurement of late night salivary cortisol (LNSF) has been advocated as a simple, non-invasive and reliable outpatient diagnostic tool for patients with suspected CS but the usefulness of its metabolite cortisone (LNSE) remains unclear. LNSE levels are approximately six times higher than LNSF in saliva due to the rapid action of 11β-hydroxysteroid dehydrogenase type 2 (11...

ea0056ep116 | Pituitary and Neuroendocrinology | ECE2018

Clinical characteristics and management of 4 patients with chordomas of the skull base attending Beaumont Hospital

Maria Tudor Roxana , Forde Hannah , Agha Amar , Faul Clare , Javadpour Mohsen

Introduction: Chordomas are rare slowly growing locally aggressive neoplasms of the bone arising from embryonic remnants of notochord. These tumours typically occur in the axial skeleton and have a proclivity for the spheno-occipital region of the skull base. Parasellar/clivus chordomas account for one third of all chordomas.Methods: We conducted a retrospective chart review of 4 patients with chordomas of the clivus treated in Beaumont Hospital between ...

ea0073aep662 | Thyroid | ECE2021

An audit of thyroidectomy in Graves’ Disease, in a large UK tertiary centre

Jones Larissa , Khan Shaila , Tolley Neil , Palazzo Fausto , Cox Jeremy , Agha-Jaffar Rochan , Robinson Stephen

BackgroundThyrotoxicosis with Graves’ Disease is treated with thionamide, radio-iodine treatment and thyroidectomy. Surgery is an important choice, especially when Graves’ Disease is complicated by thyroid orbitopathy. Pre- and post-operative protocols for thyroidectomy are imperative.Aims1) To assess pre-operative preparation of patients, with potassium iodide, vitamin D, beta blockade, and the pre...

ea0074ncc18 | Highlighted Cases | SFENCC2021

A case of iatrogenic Cushing’s disease and secondary adrenal insufficiency following a drug interaction between intra-articular triamcinolone injection and ritonavir

Khan Shaila , Walsh John , Cox Jeremy , Agha-Jaffar Rochan , Gable David

Section 1: Case history: A 50-year-old woman presented to the HIV clinic after suspecting adverse effects following two intra-articular triamcinolone injections to her left hip, administered three and seven months prior. She complained of ongoing leg pain, generalised weakness and lethargy. Her past medical history included HIV infection, mild asthma for which she took inhalers only and had never required oral steroids. Her antiretroviral medications included dolutegravir, dar...

ea0094p369 | Neuroendocrinology and Pituitary | SFEBES2023

The Natural History of Clinically Non-functioning Pituitary Macroadenomas (NFPAs) managed conservatively

Cussen Leanne , Green Deirdre , Griffin Emma , Ahmed Mohammed , Burke Kevin , Farrell Terence , Javadpour Mohsen , Agha Amar

Transsphenoidal surgery is the first-line treatment for non-functioning pituitary macroadenomas (NFPAs) causing pressure symptoms. However, the approach to asymptomatic NFPAs is unclear due to the limited data on their natural progression. This study retrospectively analysed data from patients with NFPAs who underwent conservative management for at least six months. The study screened 175 individuals treated at the National Neurosurgery/Pituitary Centre at Beaumont Hospital be...

ea0094p296 | Thyroid | SFEBES2023

A case of intravenous immunoglobulin induced thyroiditis in pregnancy

Campbell Michael , Agha-Jaffar Rochan , Saad Muhammad , Yu Christina , Robinson Stephen

Intravenous Immunoglobin (IVIG) therapy is used in recurrent miscarriage, despite its efficacy being limited to specific sub-groups such as those with underlying immune conditions. The indications, efficacy and side effect profile of IVIG when used in pregnant women are not established. We present the case of a 41-year-old pregnant woman with one previous miscarriage, who had received IVIG as part of her fertility treatment and subsequently developed profound symptoms and bioc...

ea00100wa1.3 | Workshop A: Disorders of the hypothalamus and pituitary (I) | SFEEU2024

Diabetes insipidus and compressive thyroid enlargement in adult multi-organ langerhans cell histiocytosis

Al Busaidy Merah , McEvoy Robert , O'Reilly Michael , Swan Dawn , Agha Amar

Langerhans Cell Histiocytosis (LCH) is a neoplastic histiocytic disorder that is rare in adults. LCH can present as a single or multi-site disease (mostly bone/skin). The most frequent endocrine abnormality associated with LCH is Arginine Vasopressin Deficiency (AVP-D), followed by growth hormone and gonadotropin deficiency. We present the case of a 34-year-old female with complex, sequential multi-system involvement. She had a background history of untreated Graves’ dise...