Endocrine Abstracts

Objective: Vitamin D deficiency is associated with an increased risk of type two diabetes mellitus (T2DM) and cardiovascular disease reduced through Vitamin D3 supplementation. However to the best of our knowledge, no research has determined the effect of vitamin D3 supplementation in conjunction with existing pharmacological and non-pharmacological approaches to the DMT2 population. Hence, the aim of this study was to determine the effect of vitamin D3 supplementation in a co...

Carney complex is a rare autosomal dominant syndrome characterized by multiple pigmented lesions on the mucosae and skin, cardiac myxoma, endocrine and non-endocrine tumours. It is caused by mutations of the PRKAR1A gene on chromosome 17q. We present a 24-year-old gentleman with Carney’s complex PRKAR1A gene positive. He has a strong family history of Carney complex- He also has a sister and 3 half- brothers who were also affected. One of his half-brothers has primary adr...

Diabetes Mellitus (DM) is the ninth leading cause of death worldwide. Mortality from DM is largely attributed to disease complications. Glycemic control of DM patients reduces mortality. Studies indicated that the lack of glycemic control in DM patients could be influenced by the genetic background of the patients. Evidence suggests that adiponectin levels are dysregulated in DM patients with poor glycemic control. Serum adiponectin level is a heritable trait influenced by sin...

Background: Type two Diabetes Mellitus (T2DM) is a rapidly growing crisis. Data from several T2DM cohorts demonstrate that elevated levels of serum branched chain amino acids (BCAAs) increase the risk of the disease. BCAAs levels correlate with parameters that reflect glycemic control. Elevated levels of BCAAs in T2DM is associated with a higher risk of complications. Vitamin D plays an important role in regulating insulin action on target tissues. Normalization of serum vitam...

Introduction: Since the outbreak of the COVID-19 pandemic, several cases of pituitary apoplexy following a SARS-CoV-2 infection have been described in several countries. Here, we describe a case series of pituitary apoplexy occurring in the aftermath of a SARS-CoV-2 infection to alert physicians about possible neuro-endocrinological damage caused by the virus that can lead to visual sequelae and hypopituitarism.Methods: We retrospectively identified all ...

Background: Zoledronic acid infusions are licensed for the treatment of osteoporosis and other bone disorders. Hypocalcaemia, a common side effect, increases the risk of complications. The risk of hypocalcaemia is further increased by a deficiency in 25-OH Vitamin D (VD). Pre-dose screening (PDS) is necessary to detect sub-optimal levels of serum VD and adjusted calcium (AC) early to avoid delayed treatment.Objectives: Audit adhere...

Background: Zoledronic acid infusions are licensed for the treatment of osteoporosis and other bone disorders. Hypocalcaemia, a common side effect, increases the risk of complications. The risk of hypocalcaemia is further increased by a deficiency in 25-OH Vitamin D (VD). Pre-dose screening (PDS) is necessary to detect sub-optimal levels of serum VD and adjusted calcium (AC) early to avoid delayed treatment.Objectives: Audit adhere...

Introduction: Adrenal incidentalomas (AIs) are increasingly being identified due to more frequent use of cross-sectional imaging modalities. Recent studies reported AIs being identified in 7.3% of abdominal CT imaging. Most adrenal incidentalomas are adenomas that may have secretory activity.Case Report: An 80-year-old lady presented to our Emergency department with one week’s history of worsening right eye bulging and discomfort. She was found to h...

We present a 24 year old gentleman with Multiple endocrine neoplasia type 1 with a truncating mutation in the Menin gene arising denovo. He has a past medical history of optic atrophy, pituitary macroprolactinoma in 2007 with ommaya reservoir in situ, hyperparathyroidism with subsequent parathyroidectomy (3 glands removal) and spinal osteoporosis. He had a laparoscopic pancreatic nodule enucleation for pancreatic tumours (×2 in tail of pancreas) in 2017 with his ...

A 39 years old lady who started to develop hypoglycemia three month following gastric bypass surgery. She is known to have Type 2 DM, dyslipidemia hypertension and Hirsutism. Her weight on presentation was 93.5 kg (pre operation was 104 kg) and Ha1c was 6% (pre operation was 10.5%). She was off diabetes medications. Hypoglycemia mainly fasting some readings < 3 mmol/l, with symptoms (diaphoresis, fatigue and weakness) but sometime hypoglycemia occur 2–3 h post prandia...