Endocrine Abstracts

Introduction: Brain metastases of thyroid carcinomas are rare (0.1–5%) according to the literature data. They generally occur in a context of metastatic spread which has a serious impact on survival. We report two cases and will review the literature data.Observations: Case 1: 57-year-old patient monitoring for papillary thyroid carcinoma in its solid form trabecular classified T4N0M1with lung metastases. Following a neurological symptoms of tonic-c...

Introduction: Papillary thyroid carcinoma (PTC) has generally good prognosis, and distant spread is rare. Common sites of distant metastasis are lung parenchyma and bone. Pleural metastasis is less common (0.6%), and most cases have been detected because of pleural effusion. Malignant pleural effusion is a poor prognostic factor among patients with PTC. We report a case of pleural metastasis of PTC proved by pleural biopsy.Case report: A 62-year-old man ...

Background: Integration between fat tissue, gastrointestinal tract, and the brain has attracted scientific interest in recent years. Thyroid hormones influence carbohydrate mechanisms via its interaction with adipocytokines and gut hormones. Adiponectin, ghrelin and obestatin play important roles in metabolism regulation. TSH receptors have been reported to be present in adipose tissue. Moreover, gut peptides signal to their functional cogna...

Background: Procalcitonin (PCT) is often an increased acute phase reactant in the bacterial infection-related inflammation, and its serum level is reported elevated in several autoimmune disease. However, the level of PCT and its relationship with autoimmunity remain unknown in Hashimoto’s thyroiditis (HT). Our objective was to investigate the serum levels of PCT and its association with autoantibodies in patients with euthyroid HT.Methods: A total ...

75 male was referred to endocrine service with incidental pituitary macroadenoma measuring 4.2×3.1×3.3 cm noted on MRI-C-Spine done for ankylosing spondylitis with Atlanto-axial joint instability. He had reduced secondary sexual characteristics and left quadrantanopia. Endocrine studies confirmed thyrotroph and gonadotroph failure but normal lactotroph and HPA axis. He underwent trans-sphenoidal tumour resection followed by external beam radiation due to tumour resid...

Background: Care of patients with diabetes should include an assessment of bone health. It is now clear that patients with type I DM have lower bone mineral density which may be manifested as osteopenia in growing skeleton and higher risk of fractures.Objective: To assess bone modelling through the measurement of bone formation and resorption indexes in diabetic children and their correlations with metabolic parameters.Methods: We ...

Introduction: Vitamin D insufficiency is common in older people and is associated with several disorders related to aging such as osteoporosis, which leads to a significantly increased risk of bone fractures. This deficiency is more common in Mediterranean countries than in Northern European countries. Hypocalcemic seizures resulting from vitamin D deficiency are rare in adults, and fractures caused by seizures without evidence of direct trauma have not yet been reported.<...

Diet and physical activity are éssensiels in support of diabetes mellitus (DM) as well as medical treatment.Aim: Evaluate the results of diet and physical activity on anthropometric and metabolic parameters of T2DM patients untreated population and methodology. 30 newly diagnosed T2DM patients (20W and 10 M; mean age 56.23±0.96 years were placed under hygienodietetic rules. Each patient underwent a clinical examination specifying TT, BMI, and m...

Introduction: Abnormalities of midline (AML) can be isolated or to be associated to secretory pituitary abnormalities that reflect a developmental defect of the hypothalamic pituitary (HP) region.Aim: Find AML in GH deficiency (GHD) and see their relationship with the appearance of the HP region and the severity of hypopituitarism (I P).Population and methodology: 160 children (141 ♂, ♀ 19) (IGH) underwent a clinical ex...

Introduction: Hyponatraemia is the most frequent electrolyte disturbance in clinical practice. It is encountered in isolation or as a complication of other medical conditions. The classification of hyponatraemia by volume status and severity – mild (125–134 mmol/l), moderate (115–124 mmol/l), and severe (<115) is of significance both prognostically and as a means of guiding management.Methodology: A retrospective review was carried out...