Endocrine Abstracts

Introduction: Phosphoenolpyruvate carboxykinase (PEPCK) is the key rate determining enzymes of gluconeogenesis pathway. PEPCK exists in cytosolic (PEPCK-C) and mitochondrial (PEPCK-M) isoforms. PEPCK isoforms maintain glucose/lipid homeostasis and is being explored as a therapeutic target for treating metabolic diseases. We tested the influence of a naturally occurring compound Genistein (a soy derived isoflavone) to constitutively regulate PEPCK isoforms to address its potent...

Objectives: The present study investigate the effect of light at night and rotating shift on circadian pattern of salivary cortisol and melatonin sulphate level in night shift workers and to find out whether these changes in the circadian pattern produce by night shift are reversible in due course of time. Sleep loss may be a novel risk factor for various hormones and sleep disturbances leads to metabolic and endocrinal disorders due to interference with diet, circadian metabo...

Introduction: Bilateral 3rd nerve palsy is known in conditions such as diabetes mellitus, neurosarcoidosis, Guillain-Barre syndrome, multiple sclerosis, anterior or posterior communicating artery aneurysm or mesencephalic bleed/trauma. There are only single cases reported in association with pituitary adenoma or carcinoma, usually in the context of apoplexy. We describe a patient with Cushing’s disease and bilateral 3rd nerve palsy secondary to apoplexy in pituitary macro...

Introduction: Thyroid disorders affect metabolism and body composition; however, literature data have been conflicting on whether this is also the case for thyroid hormone levels within the euthyroid range. Therefore, we have investigated the relationship between indices of thyroid status and both body composition and metabolic parameters in a population of healthy euthyroid men.Methods: Healthy male siblings (n=941, 25–45 years, median BMI 2...

Cyclical Cushing’s syndrome is typically detected by collecting sequential daily early morning urine (EMU) samples for cortisol to creatinine ratio over a 28 day period. More recently nocturnal salivary cortisol (NSC) measurement has been shown to be a sensitive means of screening for Cushing’s syndrome. The Endocrine Society have suggested that NSC may be used to assess patients for cyclical Cushing’s however there is limited evidence that it correlates with th...

Aberrant and upregulated eutopic receptors have been identified in vitro in patients with primary aldosteronism (PA). We previously identified an exaggerated aldosterone response to synacthen in patients with PA versus healthy controls. In this study we aimed to evaluate whether the synacthen test differentiates between patients with PA and essential hypertension (EH).The 250mcg intramuscular synacthen test was performed after 30 minutes recumbenc...

Bone mass density and beta cross laps have been recognized as valid tests for the diagnostic and treatment control, as well as fracture prediction for osteoporotic patients. Statin treatment has been reported to be associated with a reduced risk fracture in these patients also. However, no studies, as of our knowledge, have tried to see if adding the lipid profile to the analysis of body mass density would improve the statistical power of prediction for any of the afore mentio...

Recent findings suggested two-way interaction between bone and adipose tissue. Osteocalcin, a hormone of osteoblasts, was shown to stimulate insulin sensitivity by direct interaction with insulin. Adipose tissue has an important effect on insulin sensitivity by secretion of anti-inflammatory and proinflammatory adipocytokines like adiponectin and monocyte chemoattractant protein-1 (MCP-1). It is unknown whether they are related to bone metabolism.Aim of ...

Ovariectomy of immature female rats, results in significant decreased parameters in different organs. Previously we found that estradiol-17b (E2) restored these parameters in the different organs of ovariectomized female rats (Ovx) to values obtained in intact immature female rats. E2 also stimulated creatine kinase specific activity (CK) a hormonal-responsive marker in organs containing estrogen receptors. In the present study, we compared the effects of...

Background: In patients with hyperparathyroidism, parathyroidectomy is the only curative therapy. Anesthetic management differs function of etiology (primary vs secondary or tertiary hyperparathyroidism) and surgical technique (minimally invasive or classic parathyroidectomy).Aim: To evaluate peri-operative management in parathyroidectomy for hyperparathyroidism of various etiologies, in a tertiary center.Patients and methods: Two ...