Endocrine Abstracts

Hypercalcaemia (calcium level >2.63 mmol/L) is a common metabolic condition. In spite of its diverse aetiologies, primary hyperparathyroidism and malignancy account for more than 90% of cases, parathyroid adenoma alone contributing to 80–85% of parathyroid related cases. We describe a case of resistant hypercalcemia in a 75-year-old Afro- Caribbean gentleman.He presented with a 2-month history of constipation, loss of appetite & gradual weig...

Background: A number of reports have associated non-alcoholic steatohepatitis (NASH) with aspects of the metabolic syndrome, such as insulin resistance, dyslipidaemia, type 2 diabetes and obesity. NASH can progress to cirrhosis and hepato-cellular carcinoma, as well as acting as a marker for insulin resistance in patients with type 2 diabetes mellitus.Aims: The purpose of this study was to determine the prevalence of abnormal liver function in a populati...

Synthetic levothyroxine (L-Thyroxine) is the treatment of choice for hypothyroidism. It is safe, effective and generally well tolerated. Some patients, however, cannot tolerate L-Thyroxine. There is still some controversy about the effectiveness of combination T4 & T3 therapy. We describe 3 patients who were successfully treated with Armour thyroid (pork extract of T4 & T3) after being intolerant to L-Thyroxine.A 35 yr old lady initially presente...

Background: An increased prevalence of thyroid dysfunction is reported in both type 1 and type 2 diabetes mellitus compared to the normal population. However, the cost-effectiveness or otherwise of screening for thyroid dysfunction in this group of patients is an unresolved question.Aims: The aim of this study was to measure the effectiveness of screening for hypo- and hyperthyroidism, both sub-clinical and overt, in an ethnically diverse population of m...

To determine our adherence to the Consensus Development Conference on the Management of Asymptomatic Primary Hyperparathyroidism (2002) guidelines, we audited the management of all patients referred to our endocrine unit with the diagnosis of primary hyperparathyroidism during January 2003 to December 2004.Overall 36 patients were referred. 32 were females and the mean age was 64 years.19 patients were Caucasians, 8 were Asians and 9 patients were of Afr...

Dairy cows normally calve for the first time when not yet fully grown. Subsequent pregnancies occur during lactation. Therefore in primiparous (PP) cows the fetus competes for nutrients with maternal growth, while in multiparous (MP) cows they compete with milk production. Human epidemiological studies demonstrate that low birth weight can predispose offspring to a variety of metabolic diseases in adult life. This study investigated the hypothesis that such competition limits ...

Gender Identity Disorder (GID) has been recognised since the 1950s. The reported prevalence for GID is up to 1 in 30,000 in men and 1 in 100,000 in women. We reviewed 16 patients who were determined to have met the diagnostic criteria for GID and were referred to our clinic for advice on hormonal treatment (HT) - the second phase of the triadic treatment protocol for gender reassignment.The mean age of the group is 32years (Range 18 to 51years). Thirteen have male to femal...

An adrenal incidentaloma >4 cm of size is considered suspected of malignancy and therefore often sent to the adrenalectomy for pathological verification. In these cases, in recent studies the role of 18F-FDG-PET / TAC has been evaluated. We report a case of 67 years old man hospitalized for abdominal pain, fever and oliguria in obese patient with a history of diabetes mellitus 2, chronic renal failure, arterial hypertension and subjected to PTCA about 10 years earlier for ...

BackgroundSerum urate (SU) has been positively and independently associated with type 2 diabetes in observational studies, but causal roles remain unclear.1 Triglycerides and glucose (TyG) index can be a useful and easily performed indicator of insulin resistance for daily clinical practice.2 The aim of this study was to evaluate the association between SU and TyG index in 22-year-old participants of a birth cohort.<p class="abs...

A 64-year old man presented to our endocrinology clinic with progressive lumbar pain that had developed two months earlier. He had undergone bilateral adrenalectomy for Cushing disease and two years later transsphenoidal resection for Nelson tumor. On physical examination, the patient had remarkable hyperpigmentation due to ACTH hypersecretion periorbital, peri-auricular and in the lower-neck region. These findings were clearly evident in his case due to the extensive facial v...