Endocrine Abstracts

Initial presentation and work-up: A 42-year-old man was referred to the endocrinologist because of an incidentaloma of the right adrenal with a maximum diameter of 4.2 cm on echography of the abdomen. Echography was performed because the patient presented with icterus. An abdominal CT scan confirmed a right adrenal mass with a maximum diameter of 5.1 cm. The intensity of the adrenal adenoma amounted 39 Hounsfield units. The patient did not have a significant medical history, e...

Introduction: Most cases of prepubertal gynecomastia are classified as idiopathic. However, an exogenous or endogenous hyperestrogenism (from estrogen producing testis or adrenal tumors) has always to be excluded. Other rare underlying endocrine causes are congenital adrenal hyperplasia, aromatase excess, hyperthyroidism and hyperprolactinemia1,2.We report a transient hyperprolactinemia, beside other ignored clinical and hormonal signs of estr...

Introduction: Male obesity is associated with an increase in estradiol (E2) and a decrease in testosterone (T). And, although sex steroids are associated with cardiovascular disease, direct effects on cardiac structure and function are hardly investigated in humans.Methodology: Twenty healthy men aged 20–40 years were randomized into two groups. One group was given an aromatase inhibitor (letrozole) only, thus obtaining a high testosteron...

A 27 year old lady with Graves’ thyrotoxicosis (fT4 50.3 pmol/L, fT3 25.0 pmol/L, TSH<0.05 mU/L) failed to respond adequately to carbimazole (40 mg BD) or propylthiouracil (250 mg QDS). Three months later, following 10 days of potassium iodide to render her biochemically euthyroid, she underwent a total thyroidectomy. Pre-operative bone profile revealed Ca(c) 2.34 mmol/L (NR 2.15–2.60 mmol/L), phosphate 1.36 mmol/L (NR 0.8–1.4 mmol/L), PTH 3.4 pmol/L (NR 1.1...

The role of TSH in the pathogenesis of thyroid nodule (TN) is controversial.We have evaluated the prevalence of TN in a group of 800 subjects with and without autoimmune thyroiditis (AT). The prevalence of TN, the number and volume of nodules was evaluated in relation with TSH and antithyroid antibodies titles.The subjects were of both sex, aged between 20 and 80 years and were recruited in a random manner, in the context of an epi...

Org 36286 is a sustained follicular stimulant (SFS) inducing multiple follicular development in patients undergoing controlled ovarian stimulation. Due to its long half-life a single dose of Org 36286 may replace the first 7 injections of daily recFSH and after this one week interval, stimulation may be continued with daily recFSH up to the day of triggering ovulation (Org 36286 regimen). Ideally, recFSH should be started as soon as Org 36286 levels become too low to support m...

A 43-year old woman was referred to the endocrinologist due to resistant arterial hypertension with a history of bilateral adrenal hypertrophy. The first medical contact with the patient dates back to 2012 when she was admitted to the urology department. A CT scan of the abdomen revealed a bilateral adrenal mass, hypodens lesions in the liver and a small left kidney. Further imaging with MRI showed similar findings. The liver lesions were described as hemangiomas. Because of h...

Purpose: Deficiency of the adrenocortical axis is, except for glucocorticoid-induced adrenal deficiency, most commonly associated with failure of multiple pituitary axes and is less common isolated. Isolated adrenocorticotropic hormone deficiency (IAD) has been first described by Steinberg et al. in 1954. Acquired idiopathic IAD is defined by a secondary adrenal insufficiency with otherwise normal pituitary function, absence of structural pituitary defects, no...

Introduction: Cushing disease (CD) is a rare pathology and associated with serious complications and an increased mortality (standardized mortality ratio 2.8) (1). The mortality risk is twice as high (standardized mortality ratio 5.7) if CD is biochemically not well controlled. Transsphenoidal tumor resection is the first line treatment. However, the need for second line treatment is high, as 5-50% of patients in remission after surgery relapse and consist of ...

Introduction: Over the past years Ga-68-DOTANOC PET/CT is increasingly performed, which may lead to an increase in encountering incidentaloma. In 2022, a systematic review was published about incidentaloma on Ga-68-DOTANOC/DOTATE, describing a prevalence of 4.5% and a relatively high rate of malignancy (13%). However, it was estimated that the overall prevalence was underestimated and the frequency of malignancy overestimated because of publication bias....