Endocrine Abstracts

Polycystic ovary syndrome is the most common cause of hirsutism & menstrual irregularity in adolescent girls. It is often accompanied by obesity and insulin resistance and associated to lifelong co-morbidities including reduced fertility, type 2 diabetes, premenopausal cancer, depression, and pregnancy and offspring complications. There is no approved therapy for PCOS in adolescent girls. Oral contraceptives (OCs) are prescribed off-label to approximately 98% of young PCOS...

Children and young people (CYP) with Type 1 Diabetes who maintain a healthy BMI, diet and accurate carbohydrate-counting have lower risk of cardiovascular disease and diabetes complications. The tracking of key Diabetes health checks and outcomes via the National Paediatric Diabetes Audit (NPDA) has been successful in ensuring year-on-year improvement of national average HbA1c. Aside from BMI however, Dietetic-specific outcomes are not currently included in the NPDA. Therefore...

Case report: A 7-year-old girl presented with short stature following removal to the UK from China, where she had been diagnosed with GH deficiency on blood testing, for which GH treatment had been recommended. She had reportedly not grown well over the previous 2 years, and though the oldest in her class, she was the smallest. She had a poor appetite but otherwise was well. She had no constipation, normal activity levels, and was doing well in school. She was born at term wei...

PCOS (defined by NIH, Rotterdam or AES criteria) is traditionally viewed as an ovarian disorder that appears in adolescence and may lead to metabolic complications in adulthood. Emerging evidence, however, indicates that PCOS is primarily a disorder of adipose-tissue hyperexpansion that may originate in early life, develop across childhood and puberty, and advance into end-stage disease (including ovulatory dysfunction and ovarian androgen excess) by adolescence. Prepubertal m...

A 52-year-old, previously well Indian lady was admitted in May 2008 with pneumonia. Concurrently, she was diagnosed with diabetes mellitus (blood glucose 20 mmol/l). Her BMI was 19 kg/m2 and she was initially commenced onto sulphonylurea therapy. She had a further admission in July 2008 with dizzy episodes, falls, postural hypotension (systolic postural drop 75 mmHg) and erratic blood glucose levels (range 1.1–30 mmol/l). Blood ketones were 3.6 mmol/l without a...

After suffering three spontaneous pneumothoraces, Mr A was due to have definitive treatment in the form of video-assisted thoracoscopy and pleurodesis. Soon after ‘induction of anaesthesia’ he developed severe hypertension; 130/80 →300/220 associated with global high take off and ST elevation on the ECG. Labetol was given i.v. after which the blood pressure became unrecordable and an EMD cardiac arrest ensued. Three cycles of cardiac massage and two boluses of ...

Background: Subacute thyroiditis (SAT) is a destructive thyroiditis of probable viral origin. Thyroid dysfunction evolves through a set of stages (hyperthyroidism - hypothyroidism - euthyroidism) and is usually temporary, although some patients develop permanent hypothyroidism. The risk factors for permanent hypothyroidism remain largely unclear.Methods: A retrospective analysis of patients with SAT at the University Hospital of Brussels from 2001-2020 w...

Background: Childhood growth hormone deficiency (GHD) is a clinically heterogeneous condition and may have a genetic basis. Association with abnormalities of eyes, ears, palate and other parts of the forebrain or familial occurrence of GHD suggest a genetic cause (1). The occurrence of childhood GHD in association with gingival fibromatosis led to the identification of two autosomal dominant KCNQ1 missense variants (Arg116Leu and Pro369Leu). KCNQ1 gene encodes...

Background: Current guidelines recommend repeat evaluation of a benign thyroid nodule after 1 to 2 years, which is only based on expert opinion. Objective data are needed to evaluate this recommendation.Methods: This is a retrospective, descriptive study to describe the follow-up and incidence of malignancy in EU-TIRADS 3 nodules for which a fine needle aspiration cytology (FNAC) was indicated between 2017 and 2022. PET-positive thyroid nodules and thyro...

Inroduction: Primary hyperparathyroidism most commonly presents with hypercalcemia. Rarely, parathyroid apoplexy or haemorrhage, mimicking a thyroid bleeding cyst is the first presentation of a parathyroid adenoma(1,3).Case Report: A 55-year-old woman presented to the ENT department with a sudden onset painful goiter. Ultrasound revealed a sharply defined hypoechogenic nodule in the right thyroid lobe measuring 24.1 x 17.8 x 18.2 mm. The patie...