Endocrine Abstracts

Introduction: Many people suffered diverse diseases associated to central obesity. Actually the most frequent tool to estimate the abdominal fat is waist perimeter. In the past and the DXA software was adapted to measure fat content in abdominal region but the visceral and subcutaneous fat couldn’t be differentiated.Objective: Evaluate all tools available and establish the most sensible to discriminate the patients whose had risk to suffer metabolic...

Objective: In Cushing’s Syndrome, chronic glucocorticoid excess and their disrupted circadian rhythm lead to insulin-resistance, diabetes mellitus, dyslipidemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells may display the detrimental effects of glucocorticoid excess, thus revealing a promising model to study molecular mechanisms underlying metabolic complications of Cushing’s Syndrome.<p cl...

It is known that functional hypothalamic amenorrhea is associated with low bone turnover due to low gonadal homone levels. Estrogens are critical for activation of bone remodelling units, suppression of bone reabsorption, increase of 1-25(OH)Vitamin D receptors expression. Other mechanisms could be operative, including improper diet and unbalanced exercise; however the physiopathology of such a condition is not entirely known. In order to evaluate the correlation between pitui...

Polycystic ovary syndrome (PCOS) has an early onset. However, its prevalence in the youngest age groups has not been assessed, mostly due to the poor specificity of the criteria for defining PCOS in adolescents, including the testosterone references generated only on adult women. Moreover, the current references for testosterone were mostly built by immunoassays, known to have poor accuracy. This study was aimed at defining androgen and pro-androgen reference intervals in 149 ...

The prevalence of differentiated thyroid carcinoma (DTC) in lingual thyroid (LT) and thyroglossal duct cysts (TDC) is around 1%. Nowadays, almost 200 cases of DTC were reported in TDC and <60 cases in LT. Here we report four cases of neoplasia in LT (1/4) and TDC (3/4) in a consecutive series of 950 DTC patients (0.4%).Case 1: D.F. 63 year-old woman with thyroid follicular carcinoma in ectopic gland located at her tongue’s basis. March 2009: the...

Context: Although unexplained conflicting results are present in the literature, most of studies report the association of BRAFV600E in papillary thyroid carcinoma (PTC) with a more advanced disease and with a worst prognosis. We recently demonstrated that in most of the cases PTC consists of a mixture of tumour cells with wild-type and mutant BRAF. Hence, we examined the association of percentage of BRAFV600E alleles with clinicopathologic parameters at diagnosis and disease ...

Chronic obstructive pulmonary disease (COPD) patients could have altered endocrine function as different endocrine organs (gonads, pituitary, thyroid and pancreas) can be affected depending on the phenotype of the disease and the degree of systemic inflammation. Anabolic hormones can be involved as COPD patients can show weight loss and muscle wasting and both these conditions can modify natural history of the disease. Moreover COPD patients can frequently have acute exacerbat...

The prevalence of the metabolic syndrome is increasing worldwide. The untreated metabolic syndrome places individuals at risk both for diabetes and cardiovascular disease. Adult GH deficiency syndrome present some of the 5 features of the metabolic syndrome, abdominal obesity, high triglycerides, low HDL-cholesterol, elevations of blood glucose, hypertension and a 2-fold higher risk of death for CD compared with controls. The aim of this study was to determine the prevalence o...

Objective: Since the relationship between thymic hyperplasia (TH) and Graves’ Disease (GD) is of paramount importance for diagnostic and therapeutic choices, a wider knowledge of this association is required for endocrinologists in routine clinical practice. Our aim was to assess the prevalence, the clinical features, and the response to treatment of GD-related TH in an Academic referral centre.Methods: All consecutive cases of GD-related TH at Univ...

Rationale: Type 2 diabetes mellitus (DM) is common in patients with Cushing’s disease (CD) and Acromegaly (AC), and contributes to increased mortality. This study aimed at investigating the prevalence and characteristics of DM in CD and AC patients at diagnosis and after disease control (DC).Patients and Methods: 34 CD patients (8M,26F, 24 microadenomas(mA),6 macroadenomas (MMA) and 4 empty sella) and 35 AC patients (16M,19F, 7 mA,28 MMA) were inclu...