Endocrine Abstracts

68 years old male was admitted with cough and fever during the second UK covid surge. Recent new diagnosis of hypertension and diabetes with worsening psychotic symptoms on background of schizophrenia. Noted previous hypernatremia, hypocalcemia, hypomagnesemia along with marked refractory hypokalemia and metabolic alkalosis. Cushing’s syndrome phenotype was not noted. Failed to suppress cortisol during an overnight dexamethasone suppression test with plasma cortisol remai...

Background: Steroid profiling by LC-MS/MS is increasingly used in endocrine research, and is being introduced in the clinical practice. Due to the large disagreement with previous immunoassays, and to the enlarged panel of measurable steroids, novel and robust reference intervals (RIs) need to be established. Steroid circulating levels are known to be influenced by several physio-pathological factors, such as age, gender, stress and metabolic status. Therefore, generating unbi...

Endocrine clinical practice strongly relies on normative data for the assessment of hormonal imbalance. However, the generation of robust steroids reference intervals (RIs) remains a challenge. As the steroids circulating levels are influenced by many procedural aspects related to blood collection (time, fasting state) and physio-pathological factors, such as age, sex, stress and metabolic status, the need for partitioning RIs is mandatory. Furthermore, unbiased healthy, drug-...

Background: Thyroid hormone plays a key role in bone mineral homeostasis and significant alterations in its circulating levels has been associated with impairment in skeletal growth during childhood. To date, bone effects of subclinical hypothyroidism (SH) has not been demonstrated yet, therefore the management of this condition is still debated.Aim: To evaluate bone mineral density (BMD) in children with mild, persistent SH and the effects of two-years ...

Introduction: Adjuvant therapy with aromatase-inhibitors (AIs) increases bone loss and fracture risk. Concomitant antiresorptive treatment is currently recommended. The aim of this study was to evaluate the effects of AIs on bone metabolism and mineral density at 12 and 24 months.Methods: Among 400 women on AIs who attended our Endocrinology Unit from 2014 to 2016, we retrospectively evaluated those who initially refused antiresorptive and took cholecalc...

Context: ß-CTX are considered useful markers of response to denosumab and other anti-resorbtive treatments for osteoporosis. We report an unusual case of a completely absent effect of both denosumab and bisphosphonates on bone resorption markers.Case description: In 2017 a 74-year-old woman sought medical attention at the Endocrinology Unit of Policlinico di Sant’Orsola for the evaluation of an adrenal adenoma associated with osteoporosis. Meno...

Introduction: Women with a high breast density have an increased risk of breast cancer, which prevalence increases after menopause in obese subjects. Breast density can be calculated on mammograms as the proportion of dense tissue (percent mammographic density-PMD). Several factors may influence the PMD, including age, menopausal status, body mass index (BMI), and bone mineral density (BMD) taken as an index of overall estrogen exposure. However, conflicting data have been rep...

Primary hyperparathyroidism (PHPT) is mostly due to a benign parathyroid tumor (99%). Some have parathyroid ‘atypical adenomas’, rare tumors with histological features of parathyroid cancer (PC) (fibrous trabeculae, thick fibrous bands, mitotic figures in parenchymal cells), without local invasion or metastasis. We evaluated 20 patients with histological diagnosis of atypical adenomas. Patients were 13 women and seven males (mean age: 55±13 yrs). Nineteen patien...

Introduction: Multisystem Langerhans cell histiocytosis (LCH) is a rare heterogeneous disorder caused by accumulation in multiple organs of dendritic cells phenotypically similar to cutaneous Langerhans cells. Pituitary involvement is present in about 25% of cases, and central diabetes insipidus is the most common deficit in that setting. Panhypopituitarism is rare, but hypothalamic-pituitary dysfunction is amongst the most frequent long-term complications of the disease.<...

Abstract: An individualized risk-based approach to the treatment of thyroid cancer is being extensively discussed in the recent literature, but controversies remain about the ideal surgical approach. In particular, if some data showed that properly selected thyroid cancer patients can be treated with lobectomy (LT) with excellent clinical outcomes, other results demonstrated an increased incidence of persistent recurrent disease in patients submitted to LT with respect to thos...