Endocrine Abstracts

Spermatozoa generate small amounts of O2°- and NO°. Under physiological condition these compounds exist at very low concentration and the formation of peroxynitrite (ONOO−) appears likely. Peroxynitrite reacts rapidly with proteins, lipids and DNA. Moreover, tyrosine nitration is a widely used marker of peroxynitrite. The nitration of protein residues gives rise to 3-nitrotyrosine which represents a protein modification specific for ONOO− formation in ...

Introduction: Obesity and its associated chronic comorbidities represent a worldwide health problem in epidemic increase. Recent researches have reported notable differences in the amino acids metabolism signatures between obese, mild insulin resistant but non-diabetic, and lean individuals. Moreover, amino acids metabolites are emerging as strong predictors in the development of diabetes in obesity. The contribution of the obese adipose tissue from various depots to the syste...

Background: Obesity-related, isolated hypogonadotropic hypogonadism (IHH) occurs in more then 40% of morbidly obese men.Hypothesis: IHH and prolonged persistence of low testosterone levels after bariatric procedures may reduce the beneficial effects of surgery.Objective: To evaluate the impact of IHH on the results of bariatric surgery.Patients and methods: observational study with measurement of gonadal horm...

Introduction: Wolfram syndrome (WS) is a genetic disorder that affects the quality of life of very young Patients. This condition is also referred to as DIDMOAD (diabetes insipidus-diabetes mellitus-optic atrophy-deafness).characterized by non immunogenic diabetes mellitus, and a progressive atrophy of the optic nerve, which occurs generally in the first decade of life.In order to prevent and treat this condition, a better understanding of WS pathogenesi...

Introduction: Cytokines have been suggested to be involved in modulating anti-tumor responses and promoting tumor growth. Some studies have indicated that cytokines could also be involved in the pathogenesis of pituitary tumors. Th17 cells, characterized by expression of several cytokines as interleukin 22 (IL 22), might have a role in tumor immune-surveillance. IL-22 is a cytokine involved in the modulation of tissue responses during inflammation and, through activation of St...

DNA methylation has recently been shown to play a role in postnatal as well as developmental gene regulation. Transfer and removal of methyl groups from CpG islands in the promoter region of specific genes has been associated with gene silencing or activation, respectively. POMC is known to present several methylation sites and demethylation of these sites has been shown to be linked to POMC expression by neuroendocrine tumors outside the pituitary.<p class="...

Introduction: Male macroprolactinomas are very rare and more invasive compared to female ones. So, they are few reports concerning their response to medical treatment. We aimed to appreciate their response to Bromocriptine: the only product available in our country.Subjects and methods: 55 men (mean age: 36.3 years) with mean height pituitary tumor =38.3 mm (12–118) and mean PRL: 2942 ng/ml (132–28 000) were analyzed. Bromocriptine was given tw...

Background: Hypogonadism is a clinical entity characterized by low serum testosterone (T) levels associated with several clinical signs and symptoms which can negatively affect the quality of life. T replacement therapy (TRT), restoring serum T concentrations, improves signs and symptoms related to hypogonadism. Many T formulations are presently available. The aim of the study was to assess effects of 2% gel TRT on serum T concentrations, erectile function, muscle strength and...

Introduction: Neurohypophysis tumors also called pituicytomas are very rare low grade gliomas of the brain that developed in the posterior part of the pituitary gland. Our aim is to report two cases whose diagnosis was made by MRI in the first case and by histology in the second case.Cases reports: Observation No. 1: a woman aged 33 consulted for polyuria and polydypsia due to central diabetes insipidus without pituitary insufficiency. The MRI discovered...

Aim: Antineutrophil cytoplasmic antibody (ANCA) positivity is usually determined in medium and large vessel vasculitis. This antibody has two different forms. Cytoplasmic ANCA (PR3-ANCA) occurs against proteinase-3, while perinuclear ANCA (MPO-ANCA) occurs against myeloperoxidase and bactericidal- permeability increasing proteins. The presence of ANCA is mostly seen in systemic vasculitis and also in drug induced vasculitis. There is no sufficient data about prevalence of posi...