Endocrine Abstracts

Several studies have shown a positive correlation between parity and reduced hip fracture rate later in menopause while others have shown no correlation or a negative one. Thus, it is possible that some of the conflicting results reported in literature may be attributable to differences in the ages of the populations studied or of the concomitant presence or not of osteoporosis.In order to elucidate these conflicting results, a population based observati...

Introduction and objectives: Anxiety has a relevant impact on everyday life, including sexual life, and therefore is considered the final common pathway by which social, psychological and biological stressors negatively affect sexual functioning. The aim of this study is to define the psycho-biological correlates of free-floating anxiety in a large sample of patients complaining erectile dysfunction (ED) based sexual problems.Methods: We studied a consec...

INTRODUCTION: Intracranial tuberculomas are relatively rare lesions which may become associated with endocrinologic disturbances. We present a case of a 15-year old girl with a series of endocrine disorders commencing at 4 due to the existence of suprasellar tuberculoma lesions.CLINICAL-LABORATORY EVALUATION: A 3.5 year old girl presented with a positive tuberculin test. Since the rest of the examination and laboratory evaluation were normal, the child r...

By direct measurement of muscle sympathetic nerve activity (MSNA) we previously demonstrated a markedly decreased adrenergic tone in newly diagnosed acromegalic patients. The present study was aimed at confirming this finding in a larger group of patients and establishing the pathophysiological role of insulin resistance, GH and IGF1 levels, circulating leptin and extracellular water (ECW) in this abnormality.Study design: Fifteen de novo patients...

Introduction: Autonomous aldosterone secretion (AAS) is present in approximately 10% of hypertensives. Adrenal incidentalomas (AI) can be found in up to 19% of hypertensive individuals. However, data on the incidence of AAS in hypertensive patients with AI is scarce. Our aim was to evaluate the adrenal aldosterone secretory profile in patients with adrenal adenomas with and without arterial hypertension.Patients and methods: We investigated 72 normotensi...

Introduction: Intracavernous alprostadil injection (ICI) test has been considered useless in assessing the vascular status of subjects with erectile dysfunction (ED).Aim: To analyze the clinical correlates of ICI test in patients with ED and to verify the value of this test in predicting major adverse cardiovascular events (MACE).Methods: A consecutive series of 2,396 men (mean age 55.9±11.9 years) attending our outpatient cli...

Introduction: We previously developed and validated a structured interview (SIEDY) dealing with the organic (scale 1), relational (scale 2) and intrapsychic (scale 3) components of erectile dysfunction (ED). The aim of the present study is to identify a pathological threshold for SIEDY scale 3 and to analyze scale 3 score with biological and psychological correlates in subjects with sexual dysfunction.Method: A pathological threshold of SIEDY scale 3 sco...

Introduction: Previous studies concerning ultrasound evaluation of the seminal vesicles (SV) have been performed on a limited series of subjects, taking into consideration few parameters, often only before ejaculation and without assessing sexual abstinence of the patients. The aim of this study is to evaluate the volume and the emptying characteristics of the SV and their possible correlations with scrotal and transrectal ultrasound features.Methods: Th...

Key circulating molecules that link the emerging role of vitamin-D to pediatric obesity and its co-morbidities remain unclear. To identify potentially involved regulators, this study analyzed plasma proteoma from obese children dichotomized by 25OH-vitamin D (25OHD) levels and upon vitamin-D3 therapy in 25OHD deficient subjects.A total of 42 obese children (M/F=18/24, bmi>95° centile) were selected and divided according to 25OHD levels into defi...

Introduction: A rise in serum insulin levels during GH therapy is reported. Insulin resistance is a risk factor for type 2 diabetes, atherosclerosis, dyslipidemia, and hypertension. Few data describe insulin secretion and sensitivity after the end of GH therapy in children.Methods: Aim of our study was to evaluate changes in insulin secretion and sensitivity in 24 children with isolated GHD at 3 times: i) during the last year of therapy (T0); ii) 6 month...