Endocrine Abstracts

Introduction: The impact of metabolic syndrome (MetS) on male infertility has been poorly studied. We recently reported that MetS is associated with hypogonadism, poor sperm morphology and testis ultrasound inhomogeneity. However, the possible associations between MetS and prostate-related symptoms and signs are still lacking.Methods: Out of 351 subjects without genetic abnormalities previously evaluated for couple infertility clinically and by scrotal u...

CATSPER is a family of sperm-specific calcium channels activated by P in human spermatozoa (Lishko et al. 2011, Strunker et al. 2011). KO mice for CATSPER are infertile due to severe defects in sperm motility.We studied the involvement of CATSPER in human sperm motility and P responsiveness.Western blot analysis with an anti-CATSPER1 antibody demonstrated the presence of three major bands corresponding to CATSPER1...

Objective: To verify whether, in a large sample of male subjects seeking medical care for sexual dysfunction (SD), prostate-specific antigen (PSA) might represent a reliable marker of testosterone bioactivity, even downstream to its receptor binding.Design: Cross-sectional study.Methods: A consecutive series of 3156 patients attending our Unit for SD studied. Among them, only subjects without history of prostate disease and with PS...

Introduction: The Atherosclerosis Risk in Communities (ARIC) algorithm is one of the most efficient instruments for the prediction of incident type 2 diabetes (T2DM). Recently it has been shown to predict another relevant cardiovascular (CV) risk factor, such as chronic kidney disease.The aim of the present study is to verify whether, in patients with erectile dysfunction (ED), the use of ARIC diabetes risk score might improve the efficacy in predicting ...

Introduction: Hypoactive sexual desire is defined as a persistent or recurrent deficient or absent sexual fantasies or desire for sexual activity which should not be comorbid with other medical conditions or with the use of psychoactive medications. Reduced libido is a symptom referring more to a reduction in sexual drive for sexual activity. The aim of the present study is to investigate the risk factors of primary reduced libido (i.e. not associated with conditions causing l...

Introduction: The relational domain of erectile dysfunction (ED) is difficult to investigate in a clinical setting. We developed and validated SIEDY, a 13-item structured interview, which assesses, beside the organic (Scale1) and intra-psychic (Scale 3) domains, also the relation one (Scale 2). We previously established a pathological threshold for SIEDY Scale 1 and 3.Aim: To identify a pathological threshold of SIEDY Scale 2.Metho...

Introduction: The disorders of orgasm/ejaculation include premature ejaculation, delayed ejaculation and perceived ejaculate volume reduction (PEVR). To explore the specific associations of PEVR in subjects with erectile dysfunction (ED).Methods: A consecutive series of 3141 subjects (mean age 51.6±13.1 years old) was studied. Among these, 71 have been excluded because they underwent prostate surgery. Different clinical and biochemical factors were ...

Introduction: Perceived reduced sleep-related erections (PR-SREs), along with erectile dysfunction (ED) and hypoactive sexual desire, have been recently recognized as the most important symptoms characterizing late onset hypogonadism in community-dwelling European men. However, the clinical correlates of PR-SREs have not been thoroughly investigated. The aim of this study is to evaluate the psychobiological correlates of PR-SREs in a large series of subjects consulting for ED....

Introduction: Although several studies have demonstrated that MetS is associated with a twofold increase in the risk of cardiovascular (CV) diseases, this risk does not appear to be greater than the sum of risks associated with each of its individual components. To determine the association of men with ED and individual components of MetS and their subsequent relationship to cardiovascular (CV) risk, and, more specifically whether the sum of the MetS components is greater than...

Introduction: We previously reported that in subjects consulting for sexual dysfunction lower PRL plasma levels were associated with worse lipid and glycemic profile, as well as with a higher prevalence of metabolic syndrome and arteriogenic erectile dysfunction (ED). To assess possible associations between PRL levels and incident major cardiovascular events (MACE) in subjects with ED.Methods: This is an observational prospective cohort study evaluating ...