Endocrine Abstracts

The goal of this study was to determine whether injections of serotonin increase the plasma concentration of thyroxine (T4) , triiodothyronine (T3), growth hormone (GH), milk amount and constituents in the cows. sixty cows were randomly divide into 4 groups. Each group received daily injections of either saline or 1, 2, 4 milligrams serotonin per Kg for 15 days. Blood samples were collected daily on day 3 before injections untill 3 days after the last injection . Samples were ...

The goal of this study was to determine whether injections of bombesin increase the plasma concentration of thyroxine (T4) , triiodothyronine (T3), growth hormone (GH), milk amount and constituents in the cows. sixty cows were randomly divide into 4 groups. Each group received daily injections of either saline or 1, 2, 4 milligrams bombesinper kilogram for 15 days. Blood samples were collected daily on day 3 before injections untill 3 days after the last injection . Samples we...

A 44-year old man, previously well, presented with acute confusion and having collapsed at home. His capillary blood glucose was 2.2mmol/L and he was resuscitated with an intravenous dextrose infusion. His collapse had resulted in a fracture to his right neck of femur.Given the possibility of a pathological fracture he had a bone scan, which revealed widespread bony metastasis. In search for the primary source, an abdominal computerised tomography (CT) s...

The Thyrotropin receptor (TSHR) is known as the important key-player for regulation of thyroid growth and function. As a G-protein coupled receptor (GPCR) TSHR predominantly activates the Gs/adenylyl cyclase and the Gq/11 phospholipase C signaling pathways, that finally regulate thyroid hormone production. Aberrant thyroid hormone production can be caused by activating TSHR mutations in case of toxic thyroid nodules or non-autoimmune hyperthyroidism or via inactivating mutatio...

It has been suggested that the association between osteoporosis and cardio-vascular diseases is not just due to the aging process. The osteoprotegerin (OPG)/RANKL system has been identified as a possible mediator of arterial calcification suggesting common links between osteoporosis and vascular diseases. Moreover, breast arterial calcification (BAC) is reported to be associated with an increased prevalence of both cardiovascular risk factors and cardiovascular morbidity. In c...

Introduction: Parabens, esters of para-hydroxybenzoic acid, are widely used as an antimicrobial agent in the cosmetic products and pharmaceutical industries. Recently, it has been reported that parabens including methyl-, ethyl-, propyl-, butyl-, isopropyl-, and isobutylparaben act as xenoestrogens, a class of endocrine disruptors. In this study, we hypothesized that parabens may disrupt ovarian follicle maturation in female rats during the neonatal period.<p class="abstex...

Introduction: Preeclampsia is a pregnancy-specific disease characterized by de novo development of concurrent hypertension, proteinuria and oxidative stress in the placenta. Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation. Last trimester of gestation, the calcium and mineral transport from mother to fetus are dramatically increased in response to the accelerated demand for bone mineralization in t...

Aim: A chemiluminescence enzyme immunoassay (CLEIA) for high-molecular-weight adiponectin (HMW-ADPN) was recently developed, and has been shown to be faster, more accurate and less expensive than conventional ELISA. In this study, we investigated the relationships between metabolic parameters and the HMW-ADPN level measured by CLEIA in a health check-up setting.Methods: Informed consent was obtained from 1036 male and 416 female Japanese, 40 to 71 years ...

Adults with brain tumours experience changes in multiple aspects of quality of life and this is associated with their medical condition and its treatment. There is some evidence to suggest that the mode of treatment is also a significant factor in the development of affective symptomatology. The primary aim is to explore within our cohort of patients treated for pituitary tumours, whether there are significant differences in multiple domains of quality of life and the severity...

The successful establishment of pregnancy is dependent on appropriate embryo development and uterine receptivity. The latter consists of secretory transformation of the glandular epithelial cells followed by decidualisation of the stromal compartment. This phase of the cycle is also characterised by extensive tissue remodelling in the superficial layer of the endometrium in preparation for the invasion and implantation of the proliferating trophoblast cells. Ovarian steroids a...