Endocrine Abstracts

Introduction: Anti-Müllerian hormone (AMH) has an inhibitory role during folliculogenesis, which may contribute to anovulation in polycistic ovary syndrome (PCOS). AMH level has been shown to be a predictor of reproductive response to weight loss and clomiphene citrate in women with PCOS. The aim of this study was to evaluate the role of AMH as a predictor of improvements in menstrual cyclicity and ovulation induction by metformin in lean women with PCOS.<p class="abs...

Background: BIPSS is the most reliable procedure for differentiation Cushing’s disease (CD) from ectopic ACTH secretion (EAS).Aim: To determine the comparability of 8-mg dexamethasone supression test (BDST) and BIPSS for differential diagnosis ACTH-dependent hypercortisolism.Materials and methods: We present 6 patients with confirmed ACTH-dependent hypercortisolism. All of them BDST (8 mg dexamethasone at 2300 h) and BIPSS (wi...

Introduction: Monoclonality of pituitary adenomas is an established fact. Still, there are exceptions and polyclonality may correlate with aggressive tumor behavior. In order to test association of clonality with pituitary adenoma characteristics in a series from Romania, we implemented a protocol for X-chromosome inactivation analysis at the androgen receptor (AR) locus (HUMARA) and validated it in a number of tumor samples.Objective: To establish and v...

Primary pituitary tumors are relatively rare and mainly benign.The aim was to study the primary pituitary tumors presenting during a 10-year period in a single center.The archives of all patients with primary pituitary tumors having been hospitalized from 01.01.2000 to 30.06.2010 in the Department of Endocrinology and Metabolism of Metaxa Hospital were studied. Within this cohort of patients 128 were female (63%) and 75 (37%) were ...

Objective: To study the efficacy of lithium and perchlorate in special cases of hyperthyroidism: thioamide-resistant or iodine-induced thyroxicosis/thyrotoxic pre-crisis, hematological adverse effects of methimazole, leukopenia of other causes.Material and methods: Twenty-seven hyperthyroid patients received lithium carbonate and/or potassium perchlorate, majority after methimazole-therapy (associated with folic acid in leukopenia). We followed the clini...

Background: Previous nation-wide survey on iodine deficiency disorders (IDD) in Latvia showed a mild iodine deficiency in 587 schoolchildren (median UI – 59 μg/l). At the time less than 1% of all edible salt was iodized. Despite of the results of National IDD Elimination Committee study, all preventive measures were limited to production of leaflets promoting voluntary iodine salt consumption and convincing industry to use iodized salt. In order to perform a 10-year ...

Introduction: Elastography is a new dynamic technique that uses ultrasonography for the assessment of tissue stiffness. The principle of ultrasound-elastography is that compression of the examined tissue induces a smaller strain in hard tissues than in soft ones. Until now elastography has been applied to study the hardness and elasticity of thyroid nodules, aiming to differentiate malignant from benign ones.Aim: We decided to study if ultrasound elastog...

Wnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation. Polymorphisms in the LRP5 gene have been associated with either osteoporotic phenotypes or normal bone mineral density (BMD) variation.Objective: To explore the influence of two LRP5 single nucleotide polymorphisms (SNPs) A1330V and V667M on BMD and serum levels of osteoprotegerin (OPG), receptor activator of nuclear factor...

Introduction: Prader–Willi (PWS) is a complex genetic syndrome characterized by dysmorphic features, hypotonia, mental retardation, behavioral abnormalities, hyperphagia with progressive obesity, and endocrine dysfunctions as hypogonadism and GH deficiency. GH treatment is recommended, the major concern being aggravation of sleep apnea.Cases report: We present 2 cases with specific clinical features and genetically confirmed PWS (del 15 q11.2–q...

Objective: Calculation of accurate insulin boluses is one of the major problems related to intensive insulin regimens. A bolus calculator (BC) incorporated into the insulin pump estimates the dose of insulin to be administered at the meal and makes calculation easier and more precise.The aim of the present study was to assess the efficacy of a BC on glycaemic control of patients with DM1 on CSII.Material and methods: We enrolled 20...