Endocrine Abstracts

Introduction: Artificial pancreas systems (APS) have improved glycaemic control in adult and paediatric patients in clinical trials as part of routine clinical careAim and objectives: To evaluate the effectiveness of artificial pancreas system in routine clinical care on glycaemic control over a period of three to six months. Changes in glycated haemoglobin (HbA1c), time in range (TIR, 3.9-10 mmol/l) and time below range (TBR, <3.9 mmol/l) were asses...

Background: Immunotherapy mediated adrenocorticotrpic hormone (ACTH) deficiency is an important toxicity related to immune-checkpoint inhibitors (ICPi) potentially resulting in significant morbidity. Early diagnosis and optimal management are essential and frequently necessitate inpatient hospital treatment. We have previously reported an ambulatory management pathway for ICPi-induced ACTH deficiency in 4 patients. We sought to report the outcomes of this pathway in a larger c...

Spontaneous dizygotic (DZ) twinning results from a double ovulation and runs in families indicating a genetic component. Endocrinology studies in mothers of DZ twins observed higher levels of follicle stimulation hormone (FSH) and FSHB was, together with SMAD3, one the first loci identified as genome wide significant in genome-wide association studies (GWAS) of having DZ twins. Several additional loci were recently found that indicate genes involved with fema...

Introduction: Pituitary metastases (PM) are an uncommon manifestation of Neuroendocrine neoplasms (NENs) and are rarely reported. We report two cases of PM with different clinical lessons.Case 1: A 37-year-old female underwent surgical resection for a high grade poorly differentiated neuroendocrine carcinoma of the cervix (Ki67 90%). Serial follow-up surveillance assessments revealed disease progression (local, liver, lung, and bone) for which she underw...

Background: Prolactinomas are the most frequent secreting pituitary adenomas encountered in the clinical setting. Cabergoline is considered the mainstay medical treatment and transsphenoidal surgery (TSS) is recommended for patients that are medically resistant to dopamine agonist therapy. Resistance to dopamine agonists is commonly defined as failure to normalize prolactin and less than 50% decrease in tumor diameter at a maximal labeled dose of 2.0 mg/week. Pasireotide LAR (...

Introduction: The impairment of liver function and enhancement for NAFLD development may be attributed to the ubiquitous exposure to endocrine disrupting chemicals such as phthalates. In this study the urinary levels of monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) were compared with the parameters of hepatic function and lipids in overweight, diabetic patients and normal weight population.Methods and patients: In 305 volunteers of b...

Introduction: Adolescents spend much time using blue-light emitting screen devices such as smartphones, tablets and computers. Blue light affects the central circadian clock in the suprachiasmatic nucleus (SCN) as well as melatonin secretion by the pineal gland. Screen use in adolescents strongly associates with reduced sleep quality and sleep duration. However, there is a lack of intervention studies that reduce blue light exposure due to screen use in adolescents.<p clas...

Introduction: Pegvisomant (PEGV) is approved for the treatment of acromegaly since 2003. This is the second interim analysis of data from ACROSTUDY, with the majority of patients treated for at least five years (yrs).Methods/design: ACROSTUDY is an international, open-label, prospective, non-interventional, post-marketing surveillance study monitoring the long-term safety and efficacy of PEGV. Patients were enrolled in the study on an ongoing basis.<...

Background: The current focus of personalized medicine is towards the use of the theranostic approach – the development of an interdependent, collaborative targeted therapeutic and a companion diagnostic test. [DOTA0,D-Phe1,Tyr3]-octreotate (DOTA-TATE) and ligands targeting prostate-specific membrane antigen (PSMA) have been introduced recently as 177Lu-labeled theranostics for neuroendocrine tumors and prostate cancer respectiv...

Due to the urgent need for new prostate cancer (PCa) therapies, the role of androgen receptor (AR) interacting proteins should be investigated. In this study we aimed to address whether the AR coactivator nuclear receptor coactivator 1 (NCOA1) is involved in PCa progression. Therefore, we tested the effect of long-term NCOA1 knockdown on processes relevant to metastasis formation. [3H]-thymidine incorporation assays revealed a reduced proliferation rate in ...