Endocrine Abstracts

IntroductionDiabetes mellitus (DM) is one of the major comorbidities in patients with Coronavirus disease (COVID-19) leading to poorer outcomes. Previous evidence showed that poorly-controlled hyperglycemia increases the severity and mortality of COVID-19. Nevertheless, there is limited data on the role of in-hospital glucose control on the outcomes of elderly patients with type 2 diabetes mellitus (T2DM).Objective<p class="abs...

IntroductionIn march 2020, the COVID-19 pandemic registered its first cases in Portugal, leading the government to impose lockdown, in order to prevent the spread of cases. With social isolation and outpatient activity being ceased, there was an increase in mortality of non-COVID patients. The lockdown recommendations are in contradiction with comprehensive diabetes care and reflected in less regular patient-provider interactions, which in some cases con...

Background: The COVID-19 pandemic led to major changes in the pattern of presentation to Emergency Departments. This prompted concern within Paediatrics that this altered behaviour could lead to delays in the diagnosis of life-threatening conditions such as type 1 diabetes. A multicentre study was conducted to determine the incidence, referral patterns and severity of disease at presentation of this condition. Methods: This was a U.K.-based multi-centre ...

Background: Biochemical evidence of adrenal insufficiency (AI) is reported commonly during inhaled corticosteroid (ICS) treatment for asthma. The significance of mildly abnormal results is uncertain. For this reason we adopt a stratified approach to the management of patients with impaired cortisol responses to the low dose short Synacthen test (LDSST): Patients with peak cortisol 350–499 nmol/l (‘suboptimal’) receive hydrocortisone 20 mg/m2 per day d...

Introduction: Anti-thyroid medications are the first line therapy for children and young people with Grave’s disease (GD). Some studies have shown remission rates up to 40–50%; however long-term follow up studies have reported much lower remission rates in children compared to adults.Aim: To review the long-term follow up and management of adolescents with Grave’s disease in a single tertiary centre in the UK.Methods...

Background: Polycystic ovary syndrome (PCOS) is a heterogenous condition that affects approximately 12% of females. The diagnosis can be complex and biochemistry tests are routinely relied upon to help identify hyperandrogenaemia and to exclude other conditions. However, although national and international guidelines advocate the use biochemistry tests, little information is provided as to which tests should be used and which other endocrinopathies should be excluded.<p cl...

Sex hormone binding globulin (SHBG) is a glycoprotein which binds hormones such as testosterone. Around 97% of circulating testosterone is bound to SHBG and is therefore biologically unavailable; approximately 2–3% of testosterone is free or loosely bound to proteins such as albumin, and is biologically active, or bioavailable. Free testosterone is very technically challenging to quantify; in order to circumvent this problem, equations are used...

Sex hormone binding globulin (SHBG) is a glycoprotein which binds hormones such as testosterone. Around 97% of circulating testosterone is bound to SHBG and is therefore biologically unavailable; approximately 2–3% of testosterone is free or loosely bound to proteins such as albumin, and is biologically active, or bioavailable. Free testosterone is very technically challenging to quantify; in order to circumvent this problem, equations are used...

Objective: To describe real-world safety data on growth hormone therapy (GHT) in paediatric patients with Noonan syndrome (NS) who were enrolled in NordiNet® IOS and the ANSWER®Program.Introduction: Patients with NS have a high prevalence of cardiac defects and an increased risk for leukaemia and certain malignancies compared to the general population. Current safety data do not indicate an association of GHT with worsenin...

Previously, we reported that aphidicolin acutely increases nitric oxide (NO) production in bovine aortic endothelial cells (BAECs) by increasing phosphorylation of endothelial nitric oxide synthase at serine 1179 (p-eNOS-Ser1179) and decreasing phosphorylation at serine 116 (p-eNOS-Ser116) without altering eNOS protein expression. Here, we demonstrate that prolonged treatment with aphidicolin (over 24 h) also increased NO production in BAECs. Unlike the a...