Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep68 | Adrenal cortex (to include Cushing's) | ECE2017

The role of dehydroepiandrosterone sulphate (DHEAS) in the evaluation of autonomous cortisol secretion in adrenal incidentalomas

Adamidou Fotini , Georgiou Thomas , Mintziori Gesthimani , Tsirou Efrosini , Anagnostis Panagiotis , Panagiotou Athanasios , Kita Marina

Introduction: Subclinical hypercortisolism (SH) has been reported in 5–20% of patients with adrenal incidentalomas (AIs), with various cardiometabolic consequences. We intended to investigate the contribution of DHEAS to standard testing, as another indicator of autonomous cortisol secretion in AIs.Materials and methods: Ninety consecutive patients (n=90) with AIs were included in a prospective cohort study. SH was diagnosed if ≥2 cri...

ea0049ep828 | Thyroid (non-cancer) | ECE2017

Management of very severe Graves’ orbitopathy with low dose rituximab: report of two cases

Adamidou Fotini , Manani Christina , Anagnostis Panagiotis , Georgiou Thomas , Boboridis Kostas , Kita Marina

Introduction: Although Graves’ orbitopathy (GO) is common in the course of Graves’ disease, dysthyroid optic neuropathy and corneal breakdown are rare. We describe two cases of severe GO treated successfully with rituximab.Case 1: A 50-year-old female smoker with Graves’disease, presented with disfiguring eyelid edema, exophthalmos and diplopia, preserved visual acuity and clinical activity score (CAS) ≥ 5. She received pulsed medrox...

ea0049ep1307 | Thyroid (non-cancer) | ECE2017

Thyroid autoimmunity and frequency of malignant or suspicious for malignancy thyroid nodule cytology

Siolos Athanasios , Chambidis Vasileios , Efstathiadou Zoe , Georgiou Thomas , Panagiotou Athanasios , Adamidou Fotini , Kita Marina

Introduction: Thyroid autoimmunity has been associated with the diagnosis of differentiated thyroid (DTC) cancer in surgical series. However, this finding has not been consistent in Fine Needle Aspiration Biopsy (FNAB) cytology series.Aim: We aimed to investigate the association between thyroid autoimmunity and DTC in patients who underwent ultrasound-guided FNAB.Methods: A retrospective analysis of patients who had undergone ultra...

ea0049ep1417 | Thyroid (non-cancer) | ECE2017

Ultrasonographic features of thyroid nodules with suspicious or malignant cytology

Chambidis Vasileios , Siolos Athanasios , Lazarou Lazaros , Efstathiadou Zoe , Panagiotou Athanasios , Adamidou Fotini , Kita Marina

Introduction: Thyroid sonography has become the first line diagnostic procedure for thyroid nodules. The characterization of specific sonografic patterns associated with high risk of malignancy has enabled physicians to determine which nodules are more likely to be malignant and thus merit further evaluation.Aim: We investigated whether the ultrasonographic nodule characteristics proposed in the literature were able to predict cytology findings after ult...

ea0049ep1471 | Thyroid (non-cancer) | ECE2017

Lateral cervical lymph node metastasis from papillary thyroid cancer of undetected primary: a case report

Panagiotou Athanasios , Adamidou Fotini , Anagnostis Panagiotis , Bobos Mattheos , Hatzibougias Dimitris , Tzelepi Keraso , Kita Marina

Background: Lymph node metastasis from papillary thyroid cancer without detectable primary within the thyroid gland is extremely rare. We describe a case of a young woman with a cervical metastasis, without detectable orthotopic or ectopic thyroid focus.Case report: A 30-year old woman with a history of adenocarcinoma of the ascending colon six years previously, presented at the 15th week of a normal second pregnancy, for management of subclinical Hashim...

ea0041ep30 | Adrenal cortex (to include Cushing's) | ECE2016

Do lipid profile predict subclinical Cushing’s Syndrome in patients with adrenal incidentalomas?

Mintziori Gesthimani , Georgiou Thomas , Siolos Athanasios , Adamidou Fotini , Efstathiadou Zoe , Anagnostis Panagiotis , Panagiotou Athanasios , Kita Marina

Introduction: Adrenal Incidentalomas (AIs) have been associated with an increased risk of metabolic syndrome and dyslipidemia, though evidence regarding the latter is limited and, sometimes conflicting. Lipid abnormalities in patients with AIs have been described to be associated with subclinical hypercortisolism. Our aim was to test if lipid profile in patients with adrenal incidentalomas may predict subclinical Cushing’s Syndrome (sCS).Material an...

ea0041ep1056 | Thyroid (non-cancer) | ECE2016

ThyPROgr: translation and validation in Greek of the thyroid-specific quality of life questionnaire ThyPRO

Mintziori Gesthimani , Watt Torquill , Pournaras Dimitrios , Tzortzis Emmanouil , Kita Marina , Goulis Dimitrios

Introduction: Assessing the quality of life of patients with thyroid disease does represent a challenge. ThypRO questionnaire has been developed recently and comprises a reliable and valid scale structure of a patient-reported outcome measuring thyroid-specific quality of life.Material and methods: The standard methodology for translation of patient-reported outcomes was followed. Two independent translators, Greek native speakers, fluent in english, wer...

ea0037ep69 | Adrenal cortex | ECE2015

Prevalence and natural history of adrenal incidentalomas: a prospective cohort study

Anagnostis Panagiotis , Siolos Athanasios , Zouli Chrisanthi , Adamidou Fotini , Efstathiadou Zoe , Panagiotou Athanasios , Mintziori Gesthimani , Kita Marina

Introduction: Adrenal incidentalomas (AIs) are frequently detected due to the increasing use of abdominal imaging for diagnostic purposes. However, few prospective studies exist with respect to their natural history, regarding their size and clinical course. The aim of this study was to report the prevalence and natural history of AIs.Methods/design: Interim analysis of a prospective cohort study. The following tests were performed: serum cortisol noctur...

ea0037ep291 | Calcium and Vitamin D metabolism | ECE2015

The diagnostic value of parathyroid hormone washout after fine-needle aspiration in patients with primary hyperparathyroidism

Adamidou Fotini , Anagnostis Panagiotis , Champidis Vasileios , Katergari Simoni , Zacharioudakis Georgios , Kita Marina

Introduction: Commonly used pre-operative methods (ultrasonography and sestamibi scan) to localize the culprit parathyroid gland(s) in patients with primary hyperparathyroidism (PHPT), frequently yield false positive or false negative results. Parathyroid hormone (PTH) washout after fine-needle aspiration (FNA) may allow for a targeted surgical approach. The aim of this study was to test the diagnostic value of preoperative PTH washout after FNA in PHPT patients.<p class="...

ea0037ep301 | Calcium and Vitamin D metabolism | ECE2015

A giant parathyroid cyst manifesting with a neck mass and hypercalcaemic crisis

Adamidou Fotini , Manani Christina , Champidis Vassilis , Anagnostis Panagiotis , Kambaroudis Apostolos , Kita Marina

Introduction: Functional parathyroid cysts represent an uncommon cause of primary hyperparathyroidism (PHPT) and an even rarer cause of a cervical mass.Case report: A 57-year-old woman was referred to our department following emergency treatment of hypercalcaemic crisis (serum calcium 16.4 mg/dl) with i.v. hydration and zoledronic acid. She was found to have multiple vertebral fractures by plain radiographs one month previously. Despite being diagnosed a...