Endocrine Abstracts

Introduction: Research results from different countries show that vitamin D deficiency is a modern reality, affecting even sunny countries. Vitamin D deficiency has been related to predisposition to the development of diabetes mellitus type 2 and it may affect the secretion and action of insulin.Aim: The aim was to study the effect of vitamin D on glycaemic control in patients with diabetes mellitus type 2.Materials and methods: Th...

Acromegaly is a disease characterized by the presence of a pituitary ademona which secretes excessive amounts of growth hormone. The presence of an adenoma causing acromegaly in the context of multiple endocrine neoplasia syndromes has been described. However, the presence of solitary pituitary adenomas causing acromegaly in siblings is extremely rare.Aim: The aim was to describe acromegaly in 2 siblings.A male patient, aged 56 yea...

Gastric neuroendocrine neoplasms are rare. They are classified clinically in types 1 to 3. Gastric neuroendocrine neoplasms type 1 are observed in chronic atrophic gastritis as single or multiple small tumors. Their prognosis is excellent. Gastric neuroendocrine neoplasms type 2 are part of MEN 1 syndrome.The aim is to describe the case of a patient with a gastric neuroendocrine neoplasm which was observed in a background of atrophic gastritis and an ect...

The coexistence of multiple adenomas in endocrine glands has been described in the context of the syndromes of multiple endocrine neoplasia. However, recently the presence of adenomas in multiple endocrine glands has been described in patients not fulfilling the criteria of the syndromes of multiple endocrine neoplasia.The aim was to describe the case of a patient with a pituitary gonadotrophinoma who presented with primary hyperparathyroidism caused by ...

The management of metastatic differentiated thyroid carcinoma included until recently the use of therapeutic 131I, radiotherapy and in specific cases chemotherapy. However, recently new agents entered in the management of differentiated metastatic thyroid carcinoma which aim at specific cell receptors and inhibit the growth of the carcinoma in a specific and targeted way.The aim was to present the experience of the use of the receptor tyrosine...

Differentiated thyroid carcinoma represents a small percentage of human carcinomas. However, it is the commonest endocrine neoplasm and if diagnosed and treated properly does not affect the long-term survival of the patients.Aim: The aim was to study differentiated thyroid carcinoma affecting young adults.Patients and methods: All patients presenting with thyroid carcinoma to the department from 01.01.2002 to 31.12.2008 were review...

Medullary thyroid carcinoma is an uncommon malignancy of hereditary and sporadic presentation. Mutations in the RET-protooncogene are involved in the pathogenesis of >50% of the sporadic cases. Currently, there is no effective treatment for metastatic medullary thyroid carcinoma. The aim was to present a case of metastatic medullary thyroid carcinoma that was treated by the administration of sorafenib, a multiple kinase inhibitor.A patient, female ag...

Well differentiated thyroid carcinoma is associated with prolonged survival in terms of decades and anaplastic carcinoma is associated with survival in months. Intermediate malignancy with a more guarded prognosis is also known to exist.The aim was to describe the case of a patient with a mixed papillary, poorly differentiated and anaplastic thyroid carcinoma.A female patient, aged 73 years presented with a multinodular goiter and ...

Systemic lupus erythematosus (SLE) is a multisystem multifactorial autoimmune disorder. The survival of SLE patients has been improved by the administration of immunomodulatory therapy. Patients, however, are affected by late onset complications of the disease such as atherosclerosis. Lipoprotein Lp(a) is a known risk factor for the development of atherosclerosis.The aim was to study Lp(a) levels and their relationship with disease activity in SLE patien...

Epidemiological studies indicate that rheumatoid arthritis (RA) patients have increased mortality. Cardiovascular disease seems to be one of the major causes of death in patients with RA. Lipoprotein disorders are observed in patients with systemic autoimmune disorders as well as in patients with RA. Lipoprotein Lp(a) is an independent risk factor for the development of cardiovascular disease.The aim of the study was estimate lipoprotein Lp(a) levels and...