Endocrine Abstracts

Objective: Quality of life is currently considered a major factor in the assessment of disease outcome. The aim was to assess quality of life in acromegaly and the effect of somatostatin analogues on it.Design: This study included 101 patients with acromegaly, mean age 59.51±1.35 years (mean ± S.E.M.), with a disease duration of 12.88±0.96 years. All subjects completed the Acromegaly Quality of Life Questionnaire (AcroQoL) w...

Complete or partial edentulism is common in middle age, especially in postmenopausal women. Edentulism may be the result of either dental problems or periodontitis or both. Periodontitis is characterized by systemic inflammation and may be accompanied by osteoporosis. Osteoporotic patients on treatment with anticatabolic agents may develop osteonecrosis of the jaw. The aim was to present the management of osteoporosis in an edentulous patient with severe periodontitis who deve...

Adrenal adenomas are nowadays frequently diagnosed in the context of abdominal imaging. Osteoporosis may be a presenting manifestation of a cortisol producing adrenal adenoma. The aim was to present two cases of patients diagnosed and treated for osteoporosis who later in the course of the disease were diagnosed with a cortisol producing adrenal adenoma. Two patients, female aged 53 and 56 years, respectively, presented with osteoporosis. T score was −2.8 and &#...

Periodontitis is a serious medical condition which may lead to edentulousness in middle aged patients. It is a chronic inflammatory systemic disorder which affects the oral cavity, the maxilla and mandible. It may be associated with osteoporosis. It presents unique problems in the management of osteoporosis. The patients are in the imminent danger of losing teeth. Some of the antiosteoporotic agents may induce osteonecrosis, while they may complicate the implantation of dental...

Tocilizumab is an interleukin-6 receptor antagonist used in the treatment of rheumatoid arthritis (RA). It is known to induce remission and inhibit radiographic progression in RA. Tocilizumab may be administered either intravenously or subcutaneously. Its effect on lipid levels and the cardiovascular risk has not been fully investigated. The aim was to study the effect of tocilizumab administered either iv or sc on disease activity, lipid levels and cardiovascular risk in RA p...

Adrenal incidentalomas are increasingly recognized today as a result of technology use, such as computed tomography and magnetic resonance imaging. Adrenal incidentalomas are of diverse nature and their secretory activity is currently on research focus.The aim was to describe 39 consecutive patients with adrenal incidentalomas presenting over a period of 1 year.Materials and methods: A group of 39 consecutive patients with adrenal ...

Vitamin D deficiency is increasingly recognized today having taken the form of a modern epidemic. Vitamin D, being synthesized in the skin under the effect of ultraviolet light has been originally thought of as occurring only in areas of the world where people are not exposed to the sun. However, it has recently been observed that vitamin D deficiency exists even in sunny areas. Recent observations suggest that vitamin D deficiency is related to significant comorbidity, specif...

Male osteoporosis is a reality and in many cases appears to be secondary to drug administration. Many pharmaceutical agents are related to the appearance of osteoporosis, affecting bone metabolism by multiple and diverse mechanisms.The aim was to describe the case of a patient who presented with male osteoporosis of multiple drug aetiology.A patient, male aged 52 years, an orthodox priest, presented with spontaneous fractures and d...

Thyroid antibodies are a heterogenous group of antibodies with diverse and partly unknown properties. The effect of these antibodies on other organ systems and especially on the renal system is unknown. There is however some evidence that thyroid, in particular thyroglobulin antibodies, may affect renal function and may cause glomerulonephritis and possibly nephrotic syndrome. Nephrotic syndrome may alter thyroxine metabolism, as it affects its renal excretion and its albumin ...

Primary adrenal failure may be of autoimmune or infectious aetiology, tuberculosis being a well known cause. In tuberculosis vitamin D deficiency has been described, while vitamin D sufficiency has been reported to be necessary for the mounting of an efficient immune response to the mycobacterium.The aim was to describe the case of a patient with primary adrenal failure of tuberculous aetiology and severe vitamin D deficiency.A fem...