Endocrine Abstracts

Introduction: Consumptive hypothyroidism is a rare condition characterized by the aberrant expression and increased activity of thyroid hormone deiodinase type 3 (DIO3) in neoplastic tissue. This leads to an augmented conversion of thyroxine (T4) to the inactive reverse triiodothyronine (rT3). So far, most cases of consumptive hypothyroidism have been described in infants with hemangiomas.Case presentation: We report the case of a 64-year-old woman with ...

Introduction: FSH acts on its receptor (FSHR) resulting in signal transduction activation, gene expression and steroidogenesis. The FSHR common SNP p.N680S is a marker of gonadal response in vivo. However, in vitro dose–response experiments failed to demonstrate the molecular basis thereof so far. In this study, we systematically investigated whether p.N680S mediates different kinetics of FSH response in vitro.Des...

Introduction: The contrast agents iopanoic acid and ipodate are potent inhibitors of thyroid function, reducing type I deodinase T3 generation, inhibiting thyroid liberation of T4 and T3, and T3 receptor binding, with off-label use in hyperthyroid emergencies. However, since the interruption of iopanoic acid production this year, neither agent is currently available in Spain.Case report: A 34-year-old male was ...

Introduction: Ghrelin is an orexigenic hormone with two isoforms: Acyl Ghrelin (AG) and Desacyl Ghrelin (DAG). AG binds to its specific receptor GHS-R1 and stimulates growth hormone secretion. DAG also binds to GHS-R1 receptor, but with 1000 times less affinity than AG. Effect of DAG on cell proliferation and inhibition of apoptosis has been reported. However, there are no studies of DAG function in human placenta. For first time, this work analyzed the effect of DAG on viabil...

Objective: This study aims to assess the utility of salivary cortisol (SC) in diagnosing adrenal insufficiency (AI) and to analyze the integrity of the hypothalamic-pituitary-adrenal axis. This involves evaluating cortisol rhythm, its correlation with plasma levels, and the impact of exogenous hydrocortisone (HC) substitution on SC determination.Methods: A prospective study was conducted on all patients with suspected AI undergoing adrenocorticotropic ho...

Background: Distress tolerance (DT) has been proposed as a possible contributor to the ability to successfully adhere to difficult behaviour changes, such as stopping problematic substance and cigarette use. A number of measures of DT have been used in attempts to predict behaviour change outcomes. Findings however, have been inconclusive and no one measure has shown consistent results. Importantly, no work has yet assessed the predictive value of DT measures in successful wei...

The prevalence of prediabetes is increasing in the global population and its metabolic derangements may expose to a higher risk to develop type 2 diabetes (T2D) and its cardiovascular burden. Lifestyle modifications might have considerable benefits on ameliorating metabolic status. In light of this scenario, preventive programmes are focusing on the modification of lifestyle that notoriously decreases the incidence of T2D, to reduce the risk and delay T2D and its burden: Diabe...

Introduction: Diabetes is a chronic condition causing morbidity and mortality globally, with a growing economic burden on healthcare systems. In the UK, 1 in 14 people have diabetes, with type 2 accounting for 90% of cases (1). Complications from poorly controlled diabetes are associated with increased socioeconomic costs and a reduced quality of life. Research has shown education and self-management are crucial in helping diabetic patients achieve metabolic control (1). Smart...

Glycemic variability (GV), a complex phenomenon affecting subjects with diabetes, is one of the main contributors to the risk to develop both acute and long-term complications in type 1 (T1D) and type 2 (T2D) subjects. DNA double-strand breaks, apoptosis, overgeneration of reactive oxygen species (ROS) and the induction of some regulatory micro-RNAs, sustain the ominous mechanisms mainly attributable to GV. The characteristic cellular phenotype induced by GV is scarcely define...

Introduction: The adult Turner Syndrome (TS) clinic at UCLH has collected data on over 800 women, attending for up to 20 years comprising over 8000 clinic visits. Data from this cohort forms the Turner Life Course Project. This large dataset allows analysis of pathogenesis of common chronic conditions including diabetes mellitus (DM) and hypothyroidism. There is some debate about the classification of DM associated with TS, with an over representation of up to 11-fold of type ...