Endocrine Abstracts

Context: Type 2 diabetes (T2D) is associated with an increased incidence of infections and several cancers. Although low-grade inflammation and certain immune defects have been found in diabetic patients, the role of adaptive immune response remains to be fully elucidated.Objective: We aimed to explore whether patients with T2D show defects in the activation of T cells.Design: Immune cell phenotypes, T cell functional reactivity, s...

Introduction: Weight loss is a cornerstone in the management of prediabetes and diabetes mellitus. The association between weight and all-cause mortality is controversial and even paradoxical. Studies usually assess baseline weight. Studies assessing weight changes over time are limited. We present preliminary results of our attempt to model weight changes in patients with prediabetes and diabetes assessing the relationship with all-cause mortality.Metho...

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

A 71 year old man presented with 6 months history of pain over the nipples, weight loss of ½ stone over the previous month and nausea. Initial investigations carried out by the breast surgeons including ultrasound scan of the breast and testes were normal. He was then referred to the Endocrine department for further investigations. There was no significant past medical history, he was taking over the counter vitamins and ...

A 42 year old male was referred to the endocrine clinic with accelerated hypertension (190/110) and an elevated aldosterone renin ratio (59). CT adrenal scan revealed a 16 mm diameter mass in the posterior limb of the right adrenal gland which was confirmed to be hyperfunctioning through adrenal vein sampling. Laparoscopic adrenalectomy was performed and histology confirmed cortical adenoma of the right adrenal gland consistent with Conn’s syndr...

The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) acting via the vitamin D receptor (VDR) is a potent transcriptional regulator, with effects on skeletal and extra-skeletal physiology. We have shown previously that skeletal responses to 1,25D also involve regulation of microRNAs (miRNAs); small non-coding RNAs with an emerging role in epigenetics. To assess the role of miRNAs in innate immune responses to 1,25D we utilised in v...

A 71 year old man presented with 6 months history of pain over the nipples, weight loss of ½ stone over the previous month and nausea. Initial investigations carried out by the breast surgeons including ultrasound scan of the breast and testes were normal. He was then referred to the Endocrine department for further investigations. There was no significant past medical history, he was taking over the counter vitamins and ...

A 42 year old male was referred to the endocrine clinic with accelerated hypertension (190/110) and an elevated aldosterone renin ratio (59). CT adrenal scan revealed a 16 mm diameter mass in the posterior limb of the right adrenal gland which was confirmed to be hyperfunctioning through adrenal vein sampling. Laparoscopic adrenalectomy was performed and histology confirmed cortical adenoma of the right adrenal gland consistent with Conn’s syndr...

Background: There are no definite recommendations on the optimal dosage of initiating adjuvant radioactive iodine (RAI) therapy for intermediate-risk differentiated thyroid cancer (DTC) patients in current relevant guideline. This study aimed to investigate the response of intermediate-risk DTC patients with a low (3.7GBq) or high RAI dose (5.55GBq).Methods: Propensity score matching was performed to control for baseline characteristics. A total of 476 p...

Objective: To explore the association between body mass index (BMI) and plasma glucose level with pathological features and clinical outcomes of differentiated thyroid cancer (DTC).Methods: Clinical data of 1264 consecutive DTC patients treated with total thyroidectomy and enrolled at the time of the first 131I treatment from April 2016 to July 2020. The clinicopathological findings were compared in the groups were categorized according to BMI...