Endocrine Abstracts

Background: Osteogenesis imperfecta is a group of heterogenous disorders affecting connective tissue. The disorders are inherited by autosomal dominant or recessive patterns. The phenotypes vary both between and within the subgroups of which there are eight described by the modified Sillence criteria. The common features are reduced bone mineralization, predisposition to fracture and resulting bony deformities. In addition blue sclerae and joint hyperlaxity can be present....

Introduction: 2nd generation ‘Intact’ PTH assays currently available, measure 1–84 PTH and additional fragments. Recently a third generation kit developed which detects only active.1–84 PTH molecule, based on an immuno-radiometric sandwich assay.Design: Evaluation took place in an HMO central lab. 240 plasma samples collected. One hundred and sixty-one randomly out patients and 78 hospitalized nephrologic patien...

There are several choices for treating esophageal cancer. But only operation is the standard therapy of papillary thyroid carcinoma with esophageal invasion. Esophageal stent and gastric fistula are chose when the patient can’t swallow because of esophageal stenosis by tumor invasion. But those put a lot of strain on the patient, and lower their quality of life. To reduce the burden on patient, it is useful to adopt targeting percutaneous ethanol injection (targeting PEI)...

Introduction: Secondary causes of hypertension exist in 10% of hypertensive subjects. Hypertension refractory to antihypertensive treatment must prompt the physician to screen for secondary causes.Case presentation: A female 53-year old patient from Libya married and has three children. She works in a factory.Complaints: Headache in attacks 1 year and 4 months, palpitations 4 months. She was discovered to be severely hypertensive a...

Introduction: Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine which is associated with obesity, insulin resistance and cardiovascular disease. It is supposed that insulin has anti-inflammatory action. The aim of the present study was to estimate serum IL-18 concentration in young healthy population, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation.Methods: We studied 36 h...

Background: Diabetes mellitus is the most common endocrine metabolic disorder of childhood. It is widely spread all over Egypt as its prevalence was found to be 1.09 per 1000 among school aged children.Aim of the work: The aim of this work was to do a retrospective epidemiological study of the records of diabetic children attended the outpatient pediatric clinic in NIDE.Subjects & Methods: The files 0f 3000 diabetic children we...

Objective: Craving of sweet foods and sucrose may be a big obstacle for glycemic control of diabetic patients. It is generally believed that diabetic patients may prefer sweet taste. However, few studies have examined sucrose preference in diabetic patients. Therefore, we investigated changes in sucrose preference in diabetic condition.Research design and methods: We performed two-alternative staircase methods and forced-choice tracking procedures to ass...

Type 1 diabetes is a chronic autoimmune disease with a subclinical prodromal period characterized by the presence of circulating antibodies to various islet cell proteins. Our main objective is to estimate the prevalence of diabetes-associated autoantibodies in a group of 1st degree relatives, compared to healthy control subjects. Also, we tried to assess the insulin secretory capacity in subjects having multiple antibodies using first phase insulin response (FPIR) to intraven...

Introduction: More than 50 years after its introducing in 1957 (1996 in USA), metformin is used today in more than 90 countries. It is the most efficient, safe and costless anti-hyperglycemic agent in the treatment of type 2 diabetes mellitus. Its principal risk remains metformin-associated lactic acidosis (MALA), subject of controversies as reported in a recent Cochrane database review in 2010.Patients and methods: We present personal series of all case...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of ...