Endocrine Abstracts

Neuroendocrine tumor cells express a diverse array of activating and inhibitory receptors. Each receptor transduces a signal via individual pathways which often interact or overlap. Common stimulatory receptor families include those for EGF/TGFα, FGF, IGF, PDGF, VEGF, and TGFβ. EGF receptor (Her 1) activation results in several signal transduction cascades including Ras/Raf, MAPK, AKT and JNK leading to DNA synthesis and cell proliferation. Activated MAPK signaling i...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary pathology which encompasses a spectrum of findings ranging from simple neuroendocrine cell proliferation to discrete nodules, and is strongly associated with carcinoid tumours. Patients, typically female, are often asymptomatic, but may present with overt pulmonary symptoms, such a dyspnoea, cough or pleuritic chest pain; however, even in their absence, a degree of obstructive or mixed o...

A 39-year-old woman presented at 23 weeks gestation with extreme fatigue and non-specific neurological symptoms. Other than mild hypertension her physical examination was normal. Serum calcium was 3.36 mmol/l (normal 2.12–2.62) and phosphate 0.8 mmol/l (Normal 0.8–1.5). She was severely hypercalcemic throughout pregnancy and her corrected calcium ranged between 2.82 and 3.48 mmol/l. Other investigations included 25 hydroxy-Vitamin D3 98 (normal 75–200...

Over recent years, the numbers of commercially available slimming aids have increased dramatically. Whilst the majority of these aids are harmless, their interaction with normal physiology is either not understood or not brought to the attention of the customer. We report the case of a 45-year-old woman who presented with clinical and biochemical thyrotoxicosis (fT4 31.5 pmol/l, fT3 14.3 pmol/l, TSH <0.02 mIU/l). She had elevated TPO antibodies (51 IU...

In type 1 diabetes mellitus, tight glycaemic control is required to attenuate chronic complications and often requires daily injectable insulin therapy, which can result in non-compliance because of patient discomfort. As a result of this, some studies are concerned with optional routes of insulin administration. In our laboratory, we have developed amidated pectin (polygalacturonic acid) hydrogel beads for oral insulin administration. The aim of present was to investigate whe...

Mark E Molitch, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA AbstractMark E. Molitch, MD, is Professor of Medicine and a Member of the Division of Endocrinology, Metabolism and Molecular Medicine at Northwestern University Feinberg School of Medicine, in Chicago, Illinois. Prior to joining the faculty at Northwestern in 1984, Dr. Molitch was an Associate Professor at Tufts University School of...

Fibrous dysplasia (FD) is a relatively uncommon condition presenting with combinations of focal bone abnormalities, cutaneous hyperpigmentation and endocrinopathy. It is caused by a post-zygotic mutation in a G-protein coupled receptor (GNAS1) leading to constitutive activation of several hormone signaling pathways. Severely affected patients present in childhood with extensive bone lesions+endocrine disorder e.g. premature puberty (McCune–Albright syndrome) but less seve...

BackgroundHypercalcaemia is commonly encountered during clinical practice. SCCOHT is a rare ovarian malignancy typically found in young women. In two thirds of patients, it causes a paraneoplastic hypercalcaemia which is usually asymptomatic.Case ReportA thirty-seven-year-old lady, presented to casualty with a one -week history of worsening nausea, vomiting, anorexia, abdominal pain, polydipsia, and polyuria....

Introduction: A diagnosis of type 1 diabetes makes a huge impact on the child and family. We believe intensive training in the first-year after diagnosis is crucial in laying a solid foundation to the lifelong management of this chronic condition. To provide this intensive support and drive reduction in HbA1c we started a quality improvement project focussing on the first year of care. Previously all patients were admitted following diagnosis of diabetes for s...

Introduction: Sitosterolemia is a rare lipid disorder characterised by excessive accumulation of phytosterols in the body. There are fewer than 110 cases worldwide, and to our knowledge, there are no reported cases of adult Sitosterolemia from South-East Asia. We report our experience in diagnosing a middle-aged Chinese lady from Singapore with Sitosterolemia.Case Report: A 45-year-old Chinese lady was referred to the Endocrinology clinic in Oct 2022 by ...