Searchable abstracts of presentations at key conferences in endocrinology

ea0090p125 | Endocrine-related Cancer | ECE2023

Audit of Incidence and Management Practices of Endocrinopathies due to Immunotherapy and introducing a new locally adapted Guidelines for better monitoring and Management

Solanki Amrita , Grumett Simon , N Buch Harit

Background: Immune related adverse events (iRAEs) of the endocrine system are commonly recognised in Checkpoint Inhibitor (CTLA-4 and PD-1 inhibitors) Therapy. Clinically, endocrinopathies can present with symptoms of hormone deficiency, hormone excess or both (in the same or different glands).Aim: Audit of Incidence and Management (detection, investigation, referral and management) practices of Endocrinopathies due to Immunotherapy in Oncology departmen...

ea0064025 | A rare cause of central diabetes insipidus | BES2019

A rare cause of central diabetes insipidus

Chasseur P , Bahar N , Couturier B , Burniat A

Case: A 42-year old woman was referred to the endocrinology department for polydipsia and polyuria of sudden onset one month prior to presentation. She drank between 8 and 10 litres of water per day and complained of thirst, asthenia and lighter menstruation under her usual oral contraceptive pill. In addition to contraception she took 50 μg of L-thyroxine for Hashimoto thyroïditis. She had also a medical history of pink-red cutaneous lesions evolving for more than 1...

ea0063p561 | Diabetes, Obesity and Metabolism 2 | ECE2019

Features of type 2 diabetes mellitus in the elderly (Minsk)

Bilodid Irina , Shyshko Volha , Shalobyta N.

The article is devoted to one of the most pressing medical problems – diabetes mellitus type 2.Objective: To study the peculiarities of the course of diabetes mellitus type 2 in persons over 65 years of age; to evaluate the effectiveness of different therapy regimens for the level of HbA1C.Material and methods: The retrospective study included 100 patients with type 2 diabetes (T2D). The age of the patients: 65 to 82 years. Th...

ea0063p617 | Diabetes, Obesity and Metabolism 2 | ECE2019

Liraglutide restores the hyperglycemic oxidative imbalance and induces the expression of CRH, UCN1, UCN2 AND UCN3 neuropeptides in macroendothelial cells

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgos N.

Introduction: Liraglutide treatment reduces cardiovascular complications in patients with diabetes mellitus (DM), which may imply a favorable impact on the endothelial function. The aim of the present study was to investigate in vitro the effect of liraglutide on endothelial redox balance and the parallel expression of CRH, UCN1, 2 and 3 neuropeptides, under normoglycemic and hyperglycemic conditions.Methods: Macroendothelial cell line EAhy926 w...

ea0049ep618 | Diabetes therapy | ECE2017

Liraglutide restores the hyperglycemia-induced endothelial oxidative stress in vitro

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgios N

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

ea0041ep971 | Thyroid (non-cancer) | ECE2016

25-Hydroxy vitamin D levels and inflammatory markers in patients with graves disease activation

Ersoy Mustafa , Akalın Aysen

Objective: By the definition of vitamin D receptors in many tissues, many functions of vitamin D other than calcium homeostasis and bone metabolism were shown. A role for vitamin D is suggested in the pathogenesis of Graves disease because of the effects of vitamin D on the immune system. In our study the role of vitamin D deficiency in the activation of Graves disease, development of autoimmune thyroid disease and the relationship between vitamin D and inflammatory markers we...

ea0037ep834 | Thyroid cancer | ECE2015

What are the delays in the management of thyroid cancer?

Fung Dave F N , Aspinall Sebastian

Introduction: This audit aims to evidence the compliance of our practice with guidelines on the management of thyroid cancer. This may help to promote quality improvement in areas where there is substandard clinical care and service provision.Method: In this retrospective study, patients diagnosed with thyroid cancers at our unit between 2009 and 2014 were identified. Electronic records were examined to establish the dates of referral, clinic attendance,...

ea0033p87 | (1) | BSPED2013

Review of presentation and management of juvenile thyrotoxicosis at a single-centre between 2000 and 2010

Nanjundappa Suma , Mushtaq Talat , Alvi N Sabah

Introduction: Juvenile thyrotoxicosis is treated with anti-thyroid drugs using a block and replace or dose titration regimen. There is a high rate of relapse and majority require definitive treatment with surgical or radio-iodine ablation. Increasingly radio-iodine therapy is being used in children, particularly in the USA, but experience with this is limited in the UK. In our unit we have an experienced paediatric thyroid surgeon and we have always carried out surgery in chil...

ea0029n4 | (1) | ICEECE2012

Effect of metformin in teenagers with metabolic syndrome

Rakhimova G N , Azimova Sh Sh , Aliyeva A

Research objective: To estimate efficiency of metformin use in children and teenagers with metabolic syndrome (MetS).Materials and methods: Eighty children and teenagers aged 10–16 with exogenous-constitutional obesity (ECO) were observed. From them in 19 (23.8%) MetS was diagnosed according to diagnostic criteria of IDF (2007); 15 of them (78.9% – seven boys and eight girls) were prescribed metformin (Siofor, Berlin Chemie) in dose from 1000 t...

ea0029p86 | Adrenal cortex | ICEECE2012

Ectopic Cushings and Nocardia series

Rizwan A. , Sarfaraz A. , Jabbar A. , Islam N. , Akhter J.

Cushing’s syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing’s associated with markedly raised ACTH and cortisol levels. This leads to an impaired immune response, setting the stage for occurrence of opportunistic infections. Nocardia is a gram positive bacterial infection caused by aerobic actinomycetes in genus Nocardia. We report a series of patients diagnosed with ectopic Cushings, with growth o...