Searchable abstracts of presentations at key conferences in endocrinology

ea0029p756 | Endocrine Disruptors | ICEECE2012

A phytoestrogen, genistein, reversed 17 β-estradiol or bisphenol A-induced cell growth via downregulation of the cell cycle progression in BG-1 ovarian cancer cells

Hwang K. , Kang N. , Choi K.

One of estrogens, 17b-estradiol (E2), is a pleiotropic hormone that regulates the growth and differentiation of many tissues and also acts as a mitogen that promotes the development and proliferation of hormone-responsive cancers. Bisphenol A (BPA) is a widely used industrial compound and classified as one of endocrine disrupting chemicals (EDCs) and especially a xenoestrogen that imitates estrogen in living organisms. In this study, we examined the effect of a phytoestrogen, ...

ea0029p828 | Endocrine tumours and neoplasia | ICEECE2012

Surgical management of primary hyperparathyroidism in a unit where Intra-operative PTH (IOPTH) monitoring is not routinely performed

Rughooputh N. , Vinayagam R. , Pain S.

Introduction: Parathyroidectomy is performed in primary hyperparathyroidism using either focussed approach or bilateral neck exploration depending upon the pre-operative localisation results. The type of localising investigations and utility of intra-operative adjuncts like IOPTH vary in individual units. In our unit, parathyroid sestamibi scan and neck ultrasound (USS) are done routinely for all cases, and SPECT/CT and CT or MRI are reserved for selective patients. This study...

ea0029p961 | Female Reproduction | ICEECE2012

Plasma adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a case–control study

Singh S. , Akhtar N. , Ahmad J.

Objective: An interaction between adiponectin, steroid synthesis or action and measures of insulin resistance (IR) have been reported in the pathogenesis of polycystic ovary syndrome (PCOS). The present study was done to determine plasma adiponectin concentration (PAC) in women with and without PCOS and to assess its correlation to the hormonal and metabolic parameters including measures of IR. The effect of metformin for 6 months in PCOS was also evaluated.<p class="abste...

ea0029p1005 | Growth hormone IGF axis - basic | ICEECE2012

Variations of IGF1 in GH deficiency and Algerian health children

Fedala N. , Chentli F. , Haddam A. , Griene L.

IGF1 represent an important key player in several physiologic process, so it can be implicated in different pathologies among delays of growth. A comparative study was realized comparing a group of healthy Algerian children of normal size (n: 266) and a group presenting a GH deficiency (GHD n: 107)to a group of healthy westerners children of normal size(Serie of ROSENFIELD).The results are as follows: Before the age of 04 years, there is a ...

ea0029p1320 | Paediatric endocrinology | ICEECE2012

The median age of the onset of puberty in Uzbek boys of Tashkent city

Rakhimova G. , Gilyazetdinov K. , Alimova N. , Akbarov A.

Background: The age of the onset of puberty is much lower today than in the past century, due to the stability of the socio-economic conditions, improved quality of life and overall health of the population.Materials and methods: We examined healthy 818 boys aged from 7 to 18 years, the study was conducted between 2009 and 2011.Boys were examined in three urban districts of Tashkent city (i.e. Mirzo-Ulugbek, Shakhantaur, Yunus-Abad...

ea0029p1441 | Pituitary Clinical | ICEECE2012

Effect of a modulation of somatostatin release on TSH secretion in healthy volunteers

Bouali N. , Corvilain B. , Devuyst F.

Objectives: In normal subjects, inhibitory effect of a glucose load (OGTT) on GH secretion is probably mediated by an increase in hypothalamic release of somatostatin whereas the stimulatory effect of arginine on GH secretion is probably mediated by a decrease in somatostatin release. In humans and animals, somatostatin infusion inhibits basal and TRH-stimulated TSH secretion but little is known on the role of endogenous somatostatin in the regulation of TSH secretion. The aim...

ea0029p1454 | Pituitary Clinical | ICEECE2012

The treatment of results of endoscopic transsphenoidal surgery for GH-secreting pituitary adenomas

Tahara S. , Ishii Y. , Sanno N. , Teramoto A.

Objective: With the progress of neuroendoscopic surgery in recent years, the application of endoscopy to transnasal surgery for pituitary tumors is increasing. At our institution, endonasal surgery using an endoscope alone (eTSS) has been performed in 825 patients with pituitary adenomas since November 2001. Among them, 156 patients (18.9%) had GH-secreting pituitary adenoma (GHoma), so the outcome and complications of eTSS-treated GHomas were investigated in the present study...

ea0029p1605 | Thyroid (non-cancer) | ICEECE2012

Four families with nonautoimmune hyperthyroidism harboring the same thyrotropin receptor germline mutation (Asn406Ser) in Kumamoto Prefecture, Japan

Hishinuma A. , Tajiri J. , Nakatake N. , Fukata S.

Nonautoimmune hyperthyroidism (NAH) due to activating mutation of the TSH receptor (TSHR) gene is extremely rare. We report 4 unrelated families with NAH experienced for the last two years in Kumamoto Prefecture, Kyushu, Japan. TSHR gene mutation site of these four families are all the same: p.Asn406Ser (heterozygous). Thyroid functions observed in these families were subclinical hyperthyroidism or overt hyperthyroidism except for one case with euthyroidism. Thyroid autoantibo...

ea0029p1817 | Thyroid cancer | ICEECE2012

Clinical trial of thyroid RFA for papillary microcarcinomas

Fukunari N. , Nakano M. , Arai K.

The management of papillary thyroid microcarcinomas (PTMC) has been controversial and only observation without surgery has been advocated for the low-risk PTMC. Radio-frequency ablation(RFA)has been applied to thyroid nodule, which shows safe and useful results for benign thyroid nodules. In our institution, not only benign nodules, but thyroid malignancies have been attempted to be therapeutic objectives by RFA. The aim of this study is to evaluate the efficacy of RFA for pri...

ea0029p1826 | Thyroid cancer | ICEECE2012

Cytological thyroid: comparison (intra and interobserver) of results issued by pathologists with different skills of experience

Carvalho N. , Zocratto O. , Rodrigues A. , Nascimento T.

The wide variability of analysis obtained from the fine needle aspiration cytology (FNAC) of thyroid nodules is attributed to experience differences in their interpretation. It is known that reproducibility is a critical parameter for the clinical usefulness of a diagnostic test. However, interobserver and intraobserver reproducibility of cytological examinations of the thyroid has been very little investigated. We studied 74 patients who underwent FNAC and a thyroidectomy. Th...