Endocrine Abstracts

Understanding human pancreatic beta cell differentiation provides safe, normal pathways by which to manipulate stem cells for the ambitious treatment of Type 1 diabetes (1-3). The transcription factor Neurogenin 3 (Ngn3) is a transient, yet critical regulator of this process, committing progenitor cells to an endocrine cell fate (4). However, the downstream consequences of NGN3 expression remain incompletely understood.To identify new target genes of NGN...

Objectives: The aim of this study was to evaluate the diagnostic performance of biopsy criteria in four society ultrasonography (US)-based risk stratification systems (RSSs) or thyroid imaging reporting and data system (TIRADS) including the 2021 Korean (K)-TIRADS for thyroid nodules.Methods: Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched and other eligible articles by manual search were included to identify original articles invest...

Objectives: Radiofrequency ablation (RFA) is considered an alternative treatment for benign thyroid nodules and malignant thyroid cancers. There were various clinical practice guidelines from international societies for ablation of benign thyroid nodules. Recently, RFA is becoming a promising treatment choice for recurrence thyroid cancer, and RFA is suggested as a minimally invasive treatment for low-risk papillary thyroid microcarcinoma (PTMC). Several international societie...

Introduction: Impaired insulin sensitivity accompanies polycystic ovary syndrome (PCOS). Women with PCOS are usually at risk of premature cardiovascular disease, which increases with age and body weight. We studied the link between insulin sensitivity measured by the Matsuda Insulin Sensitivity Index (MISI) adjusted to body mass index (BMI) and age in otherwise healthy PCOS women.Methods: 250 adult women with PCOS of reproductive age (18-43 years old) un...

Objectives: SARS-Cov2 infection can lead to severe cytokine storm especially in obese patients. It is known that the cytokine storm might lead to severe clinical manifestations or even acute mortality in critically ill patients with COVID-19. Ghrelin as well as leptin can act as the proinflammatory cytokines. The essential question is whether the cytokine storm in COVID-19 patients with obesity is associated with adipokines dysregulation.Aim: The st...

Isolated hypogonadotropic hypogonadism (IHH) is known to decrease bone mineral density due to lack of pubertal surge of gonadotropins and deficiency of sex steroid hormone. Gonadal steroid hormones imbalance affects body composition. Nineteen Caucasian men, 22–48 year old (mean±S.D. 33±7.65) diagnosed with IHH (8 normosmic, 11 anosmic or hyposmic) were enrolled into the study. 14 patients were on hormone replacement therapy (HRT), 5 patients were ...

Introduction: Spacious sellar area predisposes to late diagnosis of nonfunctional pituitary adenomas and in males even the functional ones such as prolactinomas. Rising prevalence of obesity is mainly associated with sedentary lifestyle and excess of food intake. Only in rare cases has endocrine etiology such as Cushing disease, hypothyroidism or hypothalamic disorders.Case-report: A 29-year-old man was admitted to our hospital for chest pain, with a hig...

Growth hormone deficiency (GHD) in adulthood has been associated with increased central adiposity, reduced lean body mass, increased cardiovascular risk, reduced bone mineral density with increased fracture risk and decreased quality of life. GH replacement might improve these alterations.We evaluated the long-term metabolic effects of GH replacement on bone metabolism and body composition of 24 GHD patients (20 males, mean age 38±11 years, 20 adult...

Glucocorticoid (GC) excess is associated with significant brain morphological changes including loss of volume and cerebral atrophy. These effects correlate with the degree and duration of GC elevation1. The neuropsychological abnormalities associated with GC excess, however, remain poorly understood2. Patients with Cushing’s syndrome represent a useful model in which to study the effects of severe and prolonged GC excess.We pr...

69-year old male was diagnosed with non-secreting pituitary macroadenoma (25x 15x 15mm) in 2008. Patient underwent two transsphenoidal surgeries and stereotactic radiotherapy in 2008 and 2009. Tumor recurrence was noticed on MRI in 2016. In 2017 urgent right pterional craniotomy was performer due to right eyelid dropping with ocular nerves palsy. Despite surgery further growth of the tumor (32x 22x 31mm) was reported in 2018, followed by increased ACTH level and hypercortisole...