Endocrine Abstracts

Introduction: Prolactinomas in men are rare but are characterised by their giant and invasive nature. They present with signs of hypogonadism and mass effect. The aim of this study is to clarify the clinical, biological, radiological and therapeutic features of Prolactinomas in men.Patients and methods: Retrospective descriptive study including 27 adult males with a prolactin pituitary adenoma hospitalized in the endocrinology department of the Hedi Chak...

Background and Aim: Non-functioning pituitary adenoma (NFPA) is the second most common subtype of pituitary adenomas. This study aims to detail the clinical and biological particularities of NFPA in the Tunisian population.Patients and Methods: A retrospective descriptive study of 35 patients followed for NFPA was conducted between 2000 and 2022 at the endocrinology Department of Hedi Chaker University Hospital, Sfax, Tunisia.Resul...

Objective: To determine the prevalence and the associated factors of pituitary apoplexy (PA) in non-functional pituitary adenomas (NFPA). Patients and Methods: A retrospective analytical study of 35 patients followed for NFPA between 2000 and 2022 was conducted at our institution. A pituitary magnetic resonance imaging (MRI) scan was performed in all patients.Results: The mean age was 52.1±11.4 years, with a male predominance (6...

Objective: To assess the management and therapeutic outcomes of non-functioning pituitary adenomas (NFPA) in the Tunisian population.Patients and Methods: We conducted a retrospective descriptive study of 35 patients followed for NFPA between 2000 and 2022 at the endocrinology department of Hedi Chaker University Hospital.Results: The mean age was 52.1±11.4 years, with a male predominance (61.3%). The majority of tumors were bet...

Introduction: Pseudohypoparathyroidism (PHP) type 1a is a genetic disorder associated primarily with resistance to parathyroid hormone (PTH). Its pathogenesis has been linked to dysfunctional G-protein-mediated signaling. Since the G unit is an ubiquitary protein, its mutation can lead to variable hormonal dysfunction. In this context we report the case of a patient followed in our department for multihormone resistance.Case report: A 9 years old boy, bo...

Background and aim: Acromegaly is mostly due to a somatotropic adenoma. Regarding its insidious nature, this adenoma is often revealed at an invasive stage when one or more hormonal insufficiencies are already installed. This study aims to describe the clinical and biological features of hypopituitarism associated with somatotropic adenomas.Patients and Methods : We conducted a retrospective study at the Endocrinology department of Hedi Chaker University...

Introduction: Pituitary adenomas are the most frequent sellar tumors in adults. Depending on their hormonal profile in vivo and on immunohistochemistry, they present different clinical profiles and progression outcomes. Thus, we report a case of an FSH-secreting pituitary adenoma.Observation: The patient SG is 63 years old. He complained of intermittent headaches associated with a progressive decrease in visual acuity. Ophthalmological examinati...

Introduction: Turner syndrome (TS) is a genetic condition, that results from the complete or partial loss of the second X chromosome in phenotypic females. Typically, patients with TS have growth retardation, altered pubertal development and facial dysmorphism. It’s also associated with other comorbidities.Aim: Here we report a rather rare finding which is the association of TS and Rokitansky-Küster Hauser (RKH) and we discuss the possible ethi...

Introduction: Alopecia is an autoimmune disease (AID) affecting the hair follicles. Alopecia can become generalised and affect all hairy areas (universal alopecia). As with any AID, it may be associated with other AIDs. We report 2 cases of the association of alopecia with autoimmune thyroid disease (AITD).Observation: The subjects were a man and a woman aged 48 and 54 years respectively. They presented with hypothyroidism. Hashimoto’s thyroiditis (...

Introduction: Inslinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Although rare, they have the potential to produce metabolic derangements, necessitating early diagnosis. The aim of our study was to determine the clinical manifestations, diagnostic methods, treatments used and results of patients with insulinoma.Patients and methods: It’s a retrospective study including 9 patients with insulinoma, diagnose...