Searchable abstracts of presentations at key conferences in endocrinology

ea0008p33 | Diabetes, metabolism and cardiovascular | SFE2004

AUDIT OF MANAGEMENT OF DIABETIC KETOACIDOSIS IN A BUSY DISTRICT GENERAL HOSPITAL

Pal A , Fowler L , Reddy R , Elsheikh M

Objectives: To evaluate the precipitants of diabetic ketoacidosis (DKA) and to audit its management in a busy District General Hospital following the introduction of local guidelines.Methods: Data on all patients admitted with DKA between January 2003 and March 2004 were collected and analysed and clinical management was audited against the standards set in the guidelines.Results: Seventy eight episodes were recorded in 70 patients...

ea0008dp8 | Diabetes, metabolism and cardiovascular | SFE2004

AUDIT OF MANAGEMENT OF DIABETIC KETOACIDOSIS IN A BUSY DISTRICT GENERAL HOSPITAL

Pal A , Fowler L , Reddy R , Elsheikh M

Objectives: To evaluate the precipitants of diabetic ketoacidosis (DKA) and to audit its management in a busy District General Hospital following the introduction of local guidelines.Methods: Data on all patients admitted with DKA between January 2003 and March 2004 were collected and analysed and clinical management was audited against the standards set in the guidelines.Results: Seventy eight episodes were recorded in 70 patients...

ea0055p39 | Poster Presentations | SFEEU2018

Management of acromegaly in pregnancy and post-partum

Saeed Tamar , Jafar-Mohammadi Bahram , May Christine , Pal Aparna

Case history: A 39 year old female presented reporting a 5-year history of swollen face, hands and feet, with associated joint pain. She was initially investigated for rheumatoid arthritis. She had no significant past medical history except for a previous miscarriage in 2014 and treatment for hypertension in a subsequent successful pregnancy. Post-partum she breastfed with no difficulty for 18-months but remained amenorrhoeic during this time. During 2016 she noticed increase ...

ea0055p43 | Poster Presentations | SFEEU2018

SDH mutation and prolactinomas: case series

Timms Richard , May Christine , Pal Aparna , Jafar-Mohammadi Bahram

Succinate dehydrogenase (SDH) mitochondrial enzyme complex mutations are associated with hereditary paragangliomas and phaeochromocytomas. Of late, there has been more awareness of the development of other tumours in this patient cohort. There is limited evidence of propensity for development of Prolactinomas and other pituitary tumours in patients harbouring mutations in the SDH complex genes. We present three cases attending our center with a diagnosis of prolactinoma and <e...

ea0081ep10 | Adrenal and Cardiovascular Endocrinology | ECE2022

A case of ChAdOx1 vaccine-induced thrombocytopaenia and thrombosis syndrome leading to bilateral adrenal haemorrhage and adrenal insufficiency

Efthymiadis Agathoklis , Khan Dalia , Pavord Sue , Pal Aparna

Introduction: Vaccine-induced thrombosis and thrombocytopenia (VITT) after vaccination against SARS-CoV-2 with the adenoviral vector-based vaccines ChAdOx1 and Ad26.COV2.S has been associated with adrenal pathology, such as bilateral adrenal vein thrombosis, adrenal cortex haemorrhage and adrenal insufficiency in six percent of patients1.Case report: We report the case of a 23-year-old healthy woman who presented at eight days after ChAdOx1 va...

ea0082oc9 | Oral Communications | SFEEU2022

A case of ChAdOx1 vaccine-induced thrombocytopenia and thrombosis syndrome leading to bilateral adrenal haemorrhage and adrenal insufficiency

Efthymiadis Agathoklis , Khan Dalia , Pavord Sue , Pal Aparna

Case History: We report the case of a 23-year-old woman who developed adrenal insufficiency secondary to bilateral adrenal haemorrhage in the context of vaccine-induced thrombosis and thrombocytopenia (VITT). She presented with breathlessness and chest pain eight days after receiving her first dose of the adenoviral vector-based ChAdOx1 vaccine. Over the course of a week, she developed fulminant VITT. Her only comorbidity was obesity, with BMI of 35 kg/m2. <p class="abstex...

ea0086cc2 | Featured Clinical Case Posters | SFEBES2022

Coexistence of cranial diabetes insipidous and heart failure with reduced ejection fraction: a case report presenting challenges and unique therapeutic opportunities

Efthymiadis Agathoklis , H P Gamble James , Pal Aparna

History: We present the case of a 47-year-old man with heart failure (HF) and cranial diabetes insipidus (CDI) secondary to Langerhans-cell-histiocytosis. In the context of worsening HF with increasing shortness of breath and fluid retention, careful desmopressin dose reduction provided adequate aquaresis to restore euvolemia, obviating the need for usual diuretic treatments.Investigations: Echocardiography and a cardiac MRI revealed a non-dilated but se...

ea0063gp99 | Adrenal and Neuroendocrine - Basic | ECE2019

Implementation of two preclinical ACC models for a comparative drug screen and initial mechanistic investigations

Sharma Ashish , Shapiro Igor , Perge Pal , Igaz Peter , Hantel Constanze

Current systemic treatments are not satisfying for the treatment of adrenocortical carcinoma (ACC). However, translation of preclinically promising approaches were often disappointing indicating that existing tumor models might have inadequately predicted clinical applicability. Thus, our workgroup initiated a comparative drug screen of relevant chemotherapies and therapies targeting IGFR, EGFR, VEGFR/PDGFR and Wnt signalling pathway in the classical NCI-H295R and recently dev...

ea0063p125 | Diabetes, Obesity and Metabolism 1 | ECE2019

Non-Governmental Organizations (NGO’s) & Diabetes – advocacy for support services in resource-poor nations

Pal S , Roy T , Shastri V , R Pande

Background: Diabetes-support services facilities available only in few city hospitals. Especially diabetics in rural India lack comprehensive diabetes care plan. NGO’s play key role in psychosocial-support/Counseling/rehabilitation in remote towns of India. Our Project aimed to formulate policy for trained personals to give better & cost-effective Diabetes-support services.Methods: We mobilized training resources from local primary Health-center...

ea0048cp10 | Poster Presentations | SFEEU2017

Bladder paraganglioma presenting in pregnancy as an incidental mass on a first trimester scan

Navaneetham Nanthakrishna , Mackillop Lucy , Greenwood Catherine , Pal Aparna

Case history: This 32-year-old lady was found to have a 23 × 17 mm bladder mass incidentally identified on a first trimester scan and confirmed with renal tract ultrasound. Urine collections showed mildly raised normetadrenaline 4.32 umol/24 h (normal range 0–3.0), plasma normetanephrine 1339 pmol/l (120–1180), no metastases were identified on MRI and genetic screening was negative. The patient had two previous normal pregnancies and deliveries. BP in the curren...