Searchable abstracts of presentations at key conferences in endocrinology

ea0090p138 | Pituitary and Neuroendocrinology | ECE2023

Post operative copeptin does not predict occurrence of the syndrome of inappropriate antidiuresis (SIAD) after pituitary transsphenoidal surgery

Efthymiadis Agathoklis , Rostom Hussam , James Tim , Shine Brian , Guha Nishan , Cudlip Simon , Christ-Crain Mirjam , Pal Aparna

Introduction: The incidence of the syndrome of inappropriate antidiuresis (SIAD) post pituitary surgery is estimated at 3-20% with the condition potentially leading to significant morbidity and prolonged admission. Copeptin, a surrogate marker for vasopressin activity, has been shown to be a diagnostic tool in the diagnosis of AVP deficiency (formerly known as diabetes insipidus) post pituitary surgery. There is limited data regarding the utility of copeptin in predicting SIAD...

ea0090ep1133 | Late Breaking | ECE2023

An audit of ten years experience of medullary thyroid carcinoma management from a tertiary care hospital of north India

Mohan Chakraborty Ananda , Pal Rimesh , Mukherjee Soham , Nahar Uma , Dutta Pinaki , Dahiya Divya , Kumar Panda Naresh , Kumar Bhadada Sanjay

Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C-cells. It accounts for 5% of all thyroid carcinomas.Methods: A retrospective registry-based analysis of demography, clinical manifestation, genetics, management, and outcome of pathologically proven MTC cases presented in a tertiary care hospital in India was done.Results: Among 71 evaluated cases, the mean age of presenta...

ea0065oc2.6 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Post-operative copeptin analysis as a predictor of diabetes insipidus after pituitary surgery

Rostom Hussam , Noronha Sean , Jafar-Mohammadi Bahram , Halliday Jane , Cudlip Simon , James Tim , Guha Nishan , Shine Brian , Pal Aparna

Background: Diabetes insipidus (DI) is a recognised complication of pituitary surgery, with current diagnosis requiring clinical observation aided by plasma and urine electrolytes and osmolalities. Copeptin, a 39 amino acid glycopeptide secreted in equimolar quantities to ADH, is a stable surrogate marker of ADH release and has potential to facilitate prompt diagnosis of post-operative DI. This assay has been shown to accurately predict which patients are likely to develop DI ...

ea0065p293 | Neuroendocrinology | SFEBES2019

Frequency and timing of hypopituitarism as a consequence of pituitary directed radiotherapy; a retrospective cohort study

Goindoo Ryan , Hussein Furhana , Surchi Haval , Gunatilake Sonali , Ortez-Toro Jose , Cudlip Simon , Hobbs Claire , Jafar-Mohammadi Bahram , Pal Aparna

Background: Patients receiving radiotherapy for residual or recurrent pituitary adenoma require regular surveillance for the development of anterior pituitary axis deficit. Whilst the sequelae of hypopituitarism post cranial irradiation is well recognized, there are relatively varied incidences of new onset hypopituitarism post-conventional radiotherapy, reported in the literature. We aimed to investigate timing and frequency of the individual axis deficits in adults who have ...

ea0059p126 | Neuroendocrinology and pituitary | SFEBES2018

Natural history of conservatively managed Rathke’s cysts: a retrospective analysis of a single centre experience

Gargalas Sergios , Anguelova Lia , May Christine , Halliday Jane , Cudlip Simon , Jafar-Mohammadi Bahram , Joseph Robin , Pal Aparna

Rathke’s cleft cysts (RCC) arise from the embryonic remnants of Rathke’s pouch in the anterior pituitary gland. The majority are asymptomatic and incidentally diagnosed when the pituitary is imaged for other reasons. RCCs can progress to requiring surgical intervention for hormonal and structural effects. It is unclear what factors determine RCC enlargement and over what period this occurs, hence need for long term follow-up is uncertain. We analysed our conservative...

ea0059p142 | Neuroendocrinology and pituitary | SFEBES2018

A single-centre audit of treatment outcomes in 185 acromegaly patients under regular follow-up

Muhammad Shoaib Khan Sardar , Mola Laura , Perez-Fernandez Leticia , Vincent Alex , Grossman Ashley , Cudlip Simon , Jafar-Mohammadi Bahram , Pal Aparna

Transsphenoidal adenomectomy (TSA) is the recommended primary therapy in most patients with acromegaly and results in remission for majority of microadenomas and a proportion of macroadenomas depending on extent of surgically accessible disease. Acromegaly is associated with significant mortality and morbidity, hence a combination of treatment modalities may be needed to achieve disease control.Methods: A retrospective casenotes review was conducted and ...

ea0037gp.29.04 | Endocrine tumours and neoplasia – Adrenal Tumour | ECE2015

Synergistic action of 9-cis retinoic acid and mitotane in a H295R adrenocortical cancer xenograft model

Nagy Zoltan , Baghy Kornelia , Szabo Peter M , Kovalszky Ilona , Perge Pal , Patocs Attila , Racz Karoly , Igaz Peter

Background: Current drug treatment options for adrenocortical carcinoma (ACC) are rather limited and intensive efforts are going on to find novel effective agents. In our previous functional genomics study, retinoid signalling via the retinoid X receptor (RXR) was identified as a major pathogenic pathway in ACC and we have demonstrated the in vitro activity of 9-cis retinoic acid (9-cisRA) acting via the RXR on NCI-H295R cells and also found that 9-cisRA has antitumou...

ea0056gp37 | Adrenal cortex | ECE2018

MicroRNA expression profiling in adrenal myelolipoma, adrenocortical cancer and adrenocortical adenoma

Decmann Abel , Perge Pal , Nyiro Gabor , Darvasi Otto , Liko Istvan , Borka Katalin , Micsik Tamas , Patocs Attila , Igaz Peter

Background: Adrenal myelolipoma (AML) is a relatively common and invariably benign tumor composed of adipose tissue and hematopoietic elements. Due to the variable proportion of fat and hematopoietic elements, it is sometimes challenging to differentiate AML from adrenocortical carcinoma (ACC). MicroRNAs have been identified as promising biomarkers in many tumors, including adrenocortical neoplasms, but the microRNA expression of adrenal myelolipoma has not been investigated, ...

ea0056p675 | Nuclear receptors and Signal transduction | ECE2018

Inactive AT1 angiotensin receptor acts as a signaling hub: a novel mechanism of receptor cross-talk

Toth Andras D , Prokop Susanne , Gyombolai Pal , Varnai Peter , Gurevich Vsevolod V , Turu Gabor , Balla Andras , Hunyady Laszlo

It is generally believed that the signal transduction of AT1 angiotensin receptor (AT1R), the major receptor of angiotensin II, requires ligand binding and subsequent adoption of its active conformation. Activated AT1R induces a plethora of signaling pathways, in contrast to inactive AT1R, which was thought to be silent in terms of signaling. We hypothesized that unliganded, but phosphorylated AT1R may recruit β-arrestins, the key proteins of receptor desensitization, int...

ea0073aep495 | Pituitary and Neuroendocrinology | ECE2021

Efficacy and safety of cyberknife stereotactic radiosurgery in acromegaly

Seguna Desiree , Akker Scott A , Ahlquist James , Pal Aparna , Brooke Antonia , Lewis Rachel , Plowman Nick , Evanson Jane , Drake William Martyn

ObjectiveActive acromegaly is associated with increased mortality. While surgery is the mainstay of treatment, it is not always curative. In selected cases, CyberKnife stereotactic radiosurgery (CK SRS) can be used as adjuvant treatment in patients with persistent disease.DesignThis is a retrospective review of the biochemical and imaging characteristics for patients with active acromegaly treated with CK SRS...