Endocrine Abstracts

Introduction: Thyroid cancer is the most common endocrine neoplasia, with papillary thyroid carcinoma (PTC) being the subtype that represents 75 - 80% of cases; with an indolent character and a 10-year survival rate greater than 90%. Vascular infiltration is very rare in this type of tumors, which usually spread through the lymphatic route. The treatment of choice continues to be surgery with adjuvant radioiodine based on the risk stratification of recurrence and radiotherapy ...

Overweight and obesity is an escalating global health problem, affecting 40% of the population and being the 5th largest cause of death worldwide. Treatment options are limited, with pharmaceutical approaches being inadequate and the success of bariatric surgery being limited by its invasive nature. The regulation of appetite by small bioactive compounds in the gastrointestinal tract is an important target in antiobesity research. Metabolites from diet and both host and microb...

Introduction/Aims: Currently, the most successful long term treatment for obesity is bariatric surgery, however the underlying mechanisms are not fully understood. Changes in gastrointestinal and central neuroendocrine signalling have been postulated as mediators of psychological and eating behaviour changes following bariatric surgery. We aimed to investigate changes in eating behaviour and psychological factors pre- and 1 month post-very low calorie diet (VLCD) and 3-month p...

Background: Bariatric surgery has been proven to produce substantial weight loss and amelioration of metabolic syndrome-associated co-morbidities. However, at five-year follow-up, only 20–40% of patients maintain diabetes remission and 40% of patients return to their baseline weight. The limiting factor in treating refractory diabetes following obesity surgery is the lack of knowledge about its aetiology.Aims: Evaluate the eating pattern and clinica...

Introduction: An excessively long blind-end of the alimentary limb following RYGB, known as a ‘candy cane’ (CC), may cause symptoms such as pain, gastrointestinal symptoms and weight regain. Very few studies have examined the efficacy of surgical resection of the CC. We aimed to assess symptom resolution following CC surgery.Methods: Single centre observational study of 28 CC revisions from 2010 to 2017 (mean age 45±8, female preponderance...

Background: Co secreting Thyrotropin/growth hormone pituitary adenomas are rare, and their clinical presentation and long term management may be challenging. Clinically, the majority of plurihormonal pituitary adenomas are silent and diagnosis almost always relies on immunohistochemical analysis of the tumor tissue. Early detection is key to optimize patient mamagement. We report a case of pituitary plurihormonal macroadenoma with overt clinical hyperthyroidism and minimal GH ...

11-deoxycorticosterone (DOC) is an aldosterone precursor synthesized from progesterone and converted to corticosterone in the adrenal cortex. DOC overproduction due to an adrenal lesion is a very rare cause of mineralocorticoid-induced hypertension. The objective of this study is to provide the most relevant clinical features that clinicians dealing with patients presenting with the hallmarks of hypertension due to DOC-producing adrenal lesions should be aware of. We report a ...

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

Objective: 6% of people with diabetes present with diabetic foot as a complication, which means greater morbidity and mortality compared to those who do not. Its diagnosis and management by multidisciplinary teams including surgeons can improve these patients’ care. The objective was to analyze the main characteristics of patients and health results obtained, as well as to evaluate the impact of PAD (peripheral artery disease) existence in patients cared for in our multid...

Background: Gestational diabetes mellitus (GDM) is common complication in pregnancy. During pandemic COVID-19, endocrine service iniciate telemedicine in medical care and monitoring blood glucose.Purpose: The purpose of this study was to asses metabolic control and pregnancy outcome during pregnancy in telematic consult.Materials and Methods: Descriptive study of 20 patients were assesed in telematic review in the first wave of the...