Searchable abstracts of presentations at key conferences in endocrinology

ea0050ep070 | Neuroendocrinology and Pituitary | SFEBES2017

Tolosa hunt syndrome: a rare cause of hypopituitarism

Jones Alistair , O'Kane Emma , Keifer Nikki , Bremner Emma , Bhake Ragini , Levy Miles , Reddy Narendra

Introduction: Tolosa Hunt Syndrome (THS) is a steroid-responsive idiopathic inflammatory condition affecting cavernous sinus and/or orbital apex causing painful ophthalmoplegia. We present a rare case of THS resulting in hypopituitarism.Case: 45-year-old female presented with 10-day history of headache, periorbital pain and diplopia. Past medical history included bipolar disorder and bilateral below knee amputation ...

ea0050ep079 | Neuroendocrinology and Pituitary | SFEBES2017

Siadh associated with neuromyelitis optica involving hypothalamus

Papamargaritis Dimitris , Levy Miles J , Reddy Narendra L , Bhake Ragini C

A 21 year old Asian woman presented with relapse of Neuromyelitis Optica (NMO) spectrum disorder, diagnosed aged 16. She had headache, dizziness, right hand weakness and severe hyponatraemia (serum sodium [Na+] 116 [135–145]). Emesis, dominant in previous relapses, was absent – she was euvolaemic. Serum (Seosm) and urine (Uosm) osmolalities were 250 and 468 mosm/kg respectively, thyroid function ...

ea0086cc1 | Featured Clinical Case Posters | SFEBES2022

Case report: a rare case of hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome due to heterozygous pathogenic GATA3 alteration

Shafiq Shahriar , Gohil Shailesh , Bhake Ragini , Reddy Narendra , Craft Emily , Lakhani Neeta , Levy Miles

Introduction: Hypoparathyroidism may be an isolated or a component of a complex syndrome. Although genetic disorders are not the most common cause, molecular analyses have identified a growing number of genes that when defective result in impaired formation of the parathyroid glands, disordered synthesis or secretion of parathyroid hormone.Case presentation: We are reporting a 37-year-old gentleman, who is the first adult case diagnosed at our University...

ea0086p47 | Endocrine Cancer and Late Effects | SFEBES2022

A Rare Occurrence of Phaeochromocytoma in an Adult with Previously Diagnosed Wilms Tumour - Case Report

Al Jumaah Ali , Gohil Shailesh , Levy Miles J , Reddy Narendra L , Bhake Ragini

Introduction: Phaeochromocytoma affects <1:100000 people per year. Wilms tumour (WT) affects almost 1:10000 children each year. Both tumours are associated with somatic genetic alterations: Phaeochromocytoma (RET, VHL, NF1, SDHA, SDHAF2, SDHB, SDHC, SDCD, TMEM127 and MAX); WT (WT1, 11p13, 11p15, tp53, NSD1, KDM3B, BRCA2). Both tumours affecting the same person have only been reported twice in the literature.Case Report: We report a lady who, at the a...

ea0065p31 | Adrenal and Cardiovascular | SFEBES2019

The PASS score is not a reliable measure of predicting aggressive potential in phaeochromocytoma – experience over 14 years at our University Teaching Hospital

Gohil Shailesh , Seehra Jaspreet , Chauhan Vishnusai , Richards Catherine , Lloyd David , Bhake Ragini , Bhardwaj Neil , Levy Miles

Background: The phaeochromocytoma of the adrenal gland scaled score (PASS) is used for histological reporting of phaeochromocytomas as a surrogate marker of malignant potential. A PASS score of ≥4 (of a maximum of 20) suggests an aggressive tumour and hence the importance of lifelong careful follow-up. However, the utility of the PASS score has been questioned recently due to the discordance between PASS score and clinical outcomes.Aim: To review t...

ea0044p172 | Nursing Practice | SFEBES2016

Steroid replacement education: are we getting it right?

Kieffer Veronica , Bremner Emma , Robinson Carole , Bhake Ragini , Reddy Narendra , Levy Miles

Patients with Adrenal Insufficiency are potentially at risk of life threatening events if during intercurrent illness they do not take adequate glucocorticoid replacement. The National Institute for Health and Care Excellence Clinical Knowledge Summaries for this patient group recommend that they should: know how to self inject intramuscular hydrocortisone in an emergency; how to adjust their steroid replacement in response to illness; understand the importance of medical iden...

ea0059p074 | Clinical practice, governance &amp; case reports | SFEBES2018

A retrospective analysis of electronic endocrinology advice and guidance via NHS e-referral service at University Hospitals Leicester NHS Trust

Nadeem Sajjad , Aslam Waseem , Cave Helen , Bhake Ragini C , Levy Miles , Reddy Narendra L

Background: Electronic endocrinology advice and Guidance (e-Endo A&G) via NHS e-Referral Service was introduced at University Hospitals of Leicester NHS Trust (UHL) in March 2017 to address General Practitioners’ (GP) non-urgent endocrinology clinical concerns. Primary aims of the service, was to prevent inappropriate outpatient visits, avoid acute admissions and reducing length of time in resolution of queries.Objectives: To retrospectively eva...

ea0059p189 | Reproduction | SFEBES2018

From Evidence to Practice, group education as part of routine outpatient clinic in Polycystic Ovary Syndrome a proof of concept intervention

Mani Hamidreza , Reddy Narendra , Bhake Ragini , Pierides Michael , Patel Kishor , Levy Miles

Background: The benefits of patient education in women with polycystic ovary syndrome (PCOS) are known but a cost effective way to offer the education to these patients need to be assessed. As part of a quality improvement project in an outpatient setting we tested the idea of incorporating group education for women with PCOS in their routine care process. We tested two different methods.Methods: 1. January-June 2017: Ad hoc open patient invitation<p...

ea0031p324 | Steroids | SFEBES2013

Continuous measurement of free cortisol profiles

Bhake Ragini C , Leendertz Jack A , Linthorst Astrid C E , Lightman Stafford L

In order to understand the significance of circadian and ultradian hormonal rhythms in man, both in health and disease, it is essential to be able to obtain multiple samples over extended periods, especially during the hours of sleep. The human automated blood sampling (HABS) system reported by Henley and colleagues can achieve this but is recommended for use in the setting of a clinical investigation unit which is its major drawback. For many diagnostic and scientific questio...

ea0077p47 | Metabolism, Obesity and Diabetes | SFEBES2021

Leicestershire wide steroid safety programme 2019-21 and effectiveness of electronic alert on prescription software in a tertiary centre

Ahsan Masato , Zaman Sajnin , Mifsud Roberta B , Reddy Narendra L , Bremner Emma , Barrowcliffe Mary , Bhake Ragini C , Levy Miles J

Background: Omission of steroids and unsafe steroid prescription in Adrenal insufficiency (AI) patients during intercurrent illness or surgery is unfortunately common, and can lead to adrenal crisis and potentially death. Anna Mitchell et al, New Castle-upon-Tyne have demonstrated potential use of electronic automation with steroid alerts to minimise human error for ensuring patient safety.Objectives: 1. Similar use of artificial intelligence wa...