Endocrine Abstracts

Introduction: Prevalence of prolactinoma is approximately 10/100,000 (men) and 30/100,000 (women) and dopamine agonists remain pharmacological treatment of choice. Cabergoline, an effective dopamine agonist, is preferred due to better tolerability withhigher efficacy in lowering prolactin and reducing tumour size in comparison with bromocriptine. Digital vasospasm, known adverse effect of Bromocriptineis mediated by activation of α1 adrenergic receptors. ...

This case highlights the lessons learnt from a patient who was diagnosed 37 years following presentation with abnormal Thyroid Function Tests (TFTs). Mrs ID had a subtotal thyroidectomy in 1983 for thyrotoxicosis and was started on levothyroxine. She was referred to endocrine services in 2003, and was noted to have a small goitre and abnormal TFTs. Follow up consultations concentrated on thyroxine dose adjustment and querying compliance. She had a background of COPD, CVA (2018...

Introduction: Thyroid storm is a major life-threatening condition in a patient of thyrotoxicosis which can precipitate the cardiovascular morbidity in forms of tachycardia, arrythmia and congestive heart failure. It can be precipitated by acute coronary syndrome. Most literatures have reported acute coronary syndromes during the presentation itself but we describe an unique case where the diagnosis was possible after the resolution of the thyroid storm.C...

Introduction: Pituitary apoplexy (PA) is a rare endocrine emergency with less described entity being its subacute/non-acute presentation. Incidence of PA is difficult to determine, varying 2%-12% of pituitary adenoma. Hypopituitarism in PA is observed in up to 70% of cases with diabetes Insipidus (DI) observed in <5% of cases and mostly transient.Case description: 82-year old female with pituitary macroprolactinoma (1.5 cm) presented with 3-week hist...

Background: With the advent of new therapeutic modalities, the overall survival of neuroendocrine tumor (NET) patients has increased. However, the impact of the symptoms, treatments on the quality of life (QoL) of the patients, accessibility to health care, and financial toxicity are underreported in the literature. We have established a prospective NET biobank to capture the burden of the disease on patients’ daily life and the impact on their QoLM...

The zonation of the human adrenal cortex has long been established morphologically and histologically as three distinct layers of cells. The outer zona glomerulosa (ZG) comprises densely packed cells arranged in clusters that produce aldosterone; the zona fasciculata (ZF) is composed of cells with large cytoplasm, containing lipid droplets arranged in radial columns that synthetize cortisol; and the zona reticularis is composed of compact and pigmented cells producing androgen...

Background: Diabetes-support services facilities available only in few city hospitals. Especially diabetics in rural India lack comprehensive diabetes care plan. NGO’s play key role in psychosocial-support/Counseling/rehabilitation in remote towns of India. Our Project aimed to formulate policy for trained personals to give better & cost-effective Diabetes-support services.Methods: We mobilized training resources from local primary Health-center...

Introduction: Carcinoid heart disease (CHD) develops in patients with small bowel NETs with carcinoid syndrome. Currently NT-proBNP (NTP) is suggested as the best current biomarker to screen for CHD and monitor heart failure. A number of other markers have been investigated for heart failure, however, none of these have been explored in NET patients with CHD or carcinoid syndrome. Galectin-3 (GAL3) promotes fibroblast proliferation and correlates with worse outcomes in heart f...

A 39-year-old female presented with an 18-month history of borderline hypertension, headaches, palpitations and some anxiety symptoms. Both parents also had hypertension. Blood pressure was 160/102 on no medications. She had a large single cafe au lait spot but no neurofibromata. Urinary dopamine levels were repeatedly elevated (5398–8653 nmol/24 h (n<3900)) with normal noradrenaline and adrenaline levels. Serum calcium was also elevated at 2.83 mmol/l (n...

Introduction: Deranged mitochondrial biogenesis has been linked to obesity with or without type 2 diabetes but this association has not been reported in non obese type 2 diabetes subjects. This study attempts to identify the various alterations of mitochondrial biogenesis in adipose tissue in obese and non obese type 2 diabetes subjects.Methods & Design: Since type 2 diabetes is associated with elevated serum leptin and depressed serum adiponectin le...