Endocrine Abstracts

Ovariectomy of immature female rats, results in significant decrease of trabecular bone volume and in cortical bone thickness. Previously we found that estradiol-17β (E2) restored bone structure of ovariectomized female rats (Ovx) to values obtained in intact sham-operated female rats. E2 also selectively stimulated creatine kinase specific activity (CK) a hormonal-genomic activity marker. In the present study, we compared the effects of E2</sub...

Recent studies demonstrate an essential role of the EGF network in propagating the LH signal within ovarian preovulatory follicles. However, the molecular bases for the integration are poorly characterized. Here, we propose that the early LH signal leading to ovulation is amplified through activation of the EGF network.For this study, preovulatory follicles from euthanized gonadotropin-primed mice were isolated and cultured with or without recombinant LH...

Introduction: Pregnancy in women with diabetes is considered high risk because of potentially serious maternal and fetal complications that can put in to risk the maternal and fetal prognosis.Objective: Describe and analyze risks associated with diabetic pregnancies and compare maternal fetal prognosis of pregnancies with pregestational diabetes (T1D and T2D) with gestational diabetes mellitus (GDM).Patients and methods: It was a d...

Introduction: Cushing’s syndrome usually causes hypogonadism. Occurrence of pregnancy in this context is rare, and is associated with significant morbidity and perinatal mortality. We report two cases of pregnancies in two patients with Cushing’s disease.Case 1: Our first Patient was 37-year-old who presented during the second trimester of pregnancy a Cushing syndrome. The positive diagnosis was made regadless clinical signs and a hight free ur...

Background: Familial paraganglioma type 1 syndrome is a hereditary form of paraganglioma due to an autosomal dominant, paternally inherited, germinal mutation in the SDHD subunit. Intestinal pseudo-obstruction is a rare complication of secretory PGL. We present a case of a patient with a malignant PGL syndrome type 1 who developed intestinal pseudo-obstruction.Clinical case: The patient was a Dutch male, aged 39 years, carrier of a germinal mutation in e...

*These authors contributed equally to this work.BackgroundRegular physical activity has a crucial role in the control of Type 1 Diabetes (T1D). Insecurity in the management of insulin therapy and fear for dysglycemia are barriers to the practice of exercise in T1D.AimTo identify barriers to regular physical activity in adult patients with T1D; to evaluate the impact of two ed...

PurposeTo describe the role of imaging in diagnosis and detection of complications of necrotising external otitis in diabetic patients.Material and methodsOur retrospective study included 43 diabetic patients who suffered from necrotising external otitis, from 1992 to 2020. All our patients had CT scan of the temporal bones and the brain. MRI was performed in 4 cases.Results<p class...

Objectiveto analyze the clinical presentation and prognosis of Bell’s palsy in diabetic patients.Materiel and methodsThis retrospective study included 76 diabetic patients with Bell ’s palsy in the ENT department of Tahar Sfar Mahdia; Tunisia from January 1988 to December 2018. The system of House-Brackmann was used for assessing the severity of nerve damage.Results<p clas...

IntroductionIn diabetes, lipid abnormalities are frequent and pronounced and are an important factor in increased cardiovascular risk, especially in type 2 diabetics, mostly in combination with other risk factors. The aim of this work is to highlight the prevalence of dyslipidemia in a considerable population of diabetics in Es-Smara.Patients and methodsAs part of a multidisciplinary medical caravan carried o...

ObjectiveTo summarize the characteristics and treatment experience of cervicofacial odontogenic cellulitis in diabetic patients and to provide clinical basis for the diagnosis and treatment.Material and methodRetrospectively analysed 50 cases of cervicofacial cellulitis in diabetics in the ENT department of Taher Sfar Mahdia, Tunisia from from january 2015 to december 2018.Results<p...