Endocrine Abstracts

Introduction: the presence of areas with a solid / trabecular growth pattern in differentiated papillary thyroid carcinoma (PTC) represents a source of controversy regarding clinical and prognostic significance and usually requires a more aggressive therapeutic approach. The aim of this study was to compare clinicopathological characteristics, treatments and prognosis of PTC with and without solid component (SC). We also aimed to evaluate whether SC affects patient outcome in ...

Background: Chronic opioid use may lead to adrenal insufficiency (AI) due to suppression of the hypothalamic-pituitary-adrenal axis. We aimed to determine incidence of AI and mortality in patients treated with chronic opioid therapy in a standardized geographically well-defined population.Methods: In this population-based cohort study we assessed the standardized incidence rate of first time met chronic opioid use and adrenal insufficiency in adult resid...

Background: Hypoparathyroidism, a rare endocrine disorder characterised by low serum calcium due to low or insufficient parathyroid hormone levels, most commonly occurs post-surgery although can also occur due to predisposing genetic conditions or idiopathically. Hypoparathyroidism requires long-term medical management to minimise complications and detrimental impacts on health-related quality of life. Few real-world studies, particularly in the UK, have quantified healthcare ...

Background: Iron overload disorders (IOD) are associated with a higher occurrence of unbalanced calcium (Ca)-phosphorous (P) metabolism, including hypoparathyroidism (HPT). However, data about prevalence and presentation of HPT in this setting are scanty. A Ca/P ratio <2.32 has been proposed to detect HPT in the general population.Aim: To characterize Ca-P homeostasis, particularly the prevalence of HPT, in a cohort of adult patients with IOD compare...

Obesity incidence is increasing globally at an alarming rate, particularly amongst children and young adults. Male obesity has been linked with a reduction in sperm quality and consequently decreased fertilization rates. Seminal vesicles are considered fundamental for male fertility and though for men’s health. Vesicle seminal secretion contributes to a significant volume of seminal fluid, being extremely important for semen coagulation and sperm motility. Recent studies ...

Metabolic disorders, such as overweight and obesity, are serious health societal challenges due to their high incidence rates. Obesity leads to metabolic dysregulation, promoting hormonal imbalance, oxidative stress, and a chronic inflammation state. Eating habits towards the intake of highly caloric fat-rich regimes induce epigenetic changes in the information transgenerationally transmitted. Furthermore, obesity promotes carcinogenesis. It is known that the prostate is sensi...

Introduction: There are several endocrine causes of hyponatremia. SIADH is perhaps the most challenging, as patients do not always respond to initial correction measures and pharmacological treatment options are scarce. Urea is a viable option, but not commonly used.Methods: Analysis of patients with SIADH-induced hyponatremia (<135mEq/l) treated with urea per os in the Portuguese Institute of Oncology of Porto between August 2021 and Octobe...

Introduction: Nonislet cell tumour hypoglycemia (NICTH) is a rare complication of malignancy. The most common cause is overproduction of IGF2, which activates insulin receptors, resulting in hypoinsulinemic hypoglycemia. When a solitary fibrous tumor is responsible, it is called Doege-Potter syndrome.Case 1: 58-year-old woman, with a history of gastrointestinal stromal tumor and pleural solitary fibrous tumor with pulmonary and lymph node metastases. She...

Introduction: Bilateral adrenal masses may appear in the context of metastatic disease, adrenal congenital hyperplasia, primary tumors or infections, among others. Primary adrenal lymphoma is rare, accounting for approximately 1% of cases of non-Hodgkin lymphoma. Clinical case: 47-year-old woman, with a history of erythema nodosum and left hemithyroidectomy in the context of benign nodular disease. She presented with persistent fever and tiredne...

Introduction: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors that are usually benign, but which may also present as or develop into a malignancy. Predicting such behavior is notoriously difficult and there are currently no curative treatments for malignant tumors.Case Report: A male patient aged 23 years old who was investigated for headaches, flushing and palpitations. The patient presented with classic clinical features of NF-...