Endocrine Abstracts

Demonstrating a relationship between diet and atherosclerosis should provide an opportunity for potential risk reduction at an early stage of the known long disease process instead of the need to intervene at the symptomatic disease stage. Thus, we aimed to evaluate the relationship between levels of nutrients intake as determined by food frequency questionnaire (FFQ) with the degree of atherosclerotic lesions as measured by carotid intima-medial ratio (CIMT).<p class="abs...

Background and aim: KS has been classically described as characterized by hyperestrogenism and elevated serum E2 together with increased gonadotropins and low-to-normal serum testosterone (T). In literature, data on increased serum E2 are not solid. The aim of this study is to meta-analyse data from studies evaluating serum E2 in both KS and healthy subjects (HS) in order to verify if E2 is increased in KS.Meth...

Aims: Short synacthen test (SST) is commonly used to diagnose adrenal insufficiency (AI), and with serum ACTH, can help differentiate between primary and secondary AI. The aim of this audit was to evaluate the clinical appropriateness of SST in our endocrine unit.Methods: We looked at all SSTs performed between August 2012 and August 2013. Relevant clinical information was collected from patient notes and database. A SST was considered inappropriate if n...

Background: Polycystic ovary syndrome (PCOS) is characterised by anovulation and insulin resistance but the effects on reproductive outcomes are unclear.Objectives: To determine the impact of PCOS upon fertility, pregnancy complications and delivery method.Methods: Data were extracted from the Clinical Practice Research Datalink. Patients with a diagnosis of PCOS (2000–2012) were matched to controls (1:2) by age (±1 year)...

Adrenocortical carcinoma (ACC) is an aggressive cancer, with, in its advanced stages, a median 5-year survival rate of less than 15%. ACC is rare in humans, but in dogs the incidence is at least 100 times higher. Because these dogs receive medical care, have an intact immune system, and have inter-individual and intratumoral heterogeneity, the dog is a unique spontaneous animal model to study new treatment options for ACC. However, to determine similarity of canine and human A...

Objectives: A retrospective review of adult patients with Turner syndrome (TS) attending a joint Turner syndrome clinic.Methods: Sixty-two adult patients with TS clinic were identified. Data was collected from case notes and electronic records.Results: Diagnosis was prenatal/at birth in 20%, 1–10 years in 29%, 11–20 years in 47% and after 21 years in one patient. Common presenting complaints were short stature (51%) and p...

A 44-year-old women without personal or familial pathological history, presented 8 months before her admission a paroxystic symptomatology made of palpitations, headache and profus sweat associated with major abdominal pain, evolving in a context of alteration of the general state. Clinical examination objectified high blood pressure and tachycardia. Laboratory testing confirmed the diagnosis of pheochromocytoma. A computed tomography of the abdomen revealed a bilateral adrena...

Although NICE guidelines recommend that radioiodine is the first-line treatment for Graves disease, carbimazole is often used initially to get control of the hyperthyroidism. This patient was exquisitely sensitive to carbimazole initially, and despite initial recurrence, he cannot be treated with radioiodine as he now has intermittent hypothyroidism.Case: A 42-year-old male was diagnosed with Grave’s disease and initially treated fo...

Hypoglycemia in non-diabetic patients is a rare event, and autoimmune hypoglycemia with the presence of positive anti-insulin antibodies is even rarer.We report the case of a 15 years old non diabetic female patient, she was referred to our hospital for recurrent hypoglycemia for 2 weeks before admission to hospital, these are severe hypoglycemia with impaired consciousness. The first step was to eliminate the general causes and factitious hypoglycemia. ...

Background: Ectopic ACTH secretion from metastatic acinic cell carcinoma (ACC) of the parotid gland is extremely rare. ACC is an uncommon, typically indolent, salivary gland neoplasm. Herein, we report a case of a high-grade ACC later diagnosed with Cushing’s syndrome (CS).Case presentation: A 60-year-old man presented with a laterocervical mass. Computed tomography (CT) documented a 39×38 mm mass on the parotid gland and homolateral cervical l...