Endocrine Abstracts

Introduction: Pasireotide reduced UFC levels in 22 of 29 patients with Cushing’s disease after 15 days’ treatment (Boscaro et al. JCEM 2009). Of these 22 patients, 5 achieved normalized UFC (UFC-responders) and 17 had reduced but not normalized UFC (UFC-reducers). Results of an extension phase to this study are presented.Methods: Patients with de novo or persistent/recurrent Cushing’s disease received pasireotide 600 μg ...

Objective: We aimed to evaluate the frequency of malignancy in patients with follicular lesion or follicular neoplasia in cytological examination.Method: About 29 patients who had follicular neoplasia or follicular lesion in cytological examination after ultrasound guided thyroid fine needle aspiration biopsy (FNAB) were included in the study. Histopathologic results were evaluated after thyroidectomy in all patients.Results: There...

Introduction: The incidence, cell origin, histopathologic features and prognosis of papillary and medullary carcinoma are considered to be completely different. Simultaneous occurrence of medullary and papillary thyroid carcinoma in the same patient is rare. Here, we present a patient with synchronous medullary thyroid carcinoma and papillary microcarcinoma occurring in a thyroid with chronic lymphocytic thyroiditis.Case: A 47 years old woman with no his...

Background: Ca 19-9 is a tumor-associated antigen. In this study, we aimed to compare Ca 19-9 levels in type 2 diabetes mellitus (DM) patients and healthy control group.Method: Two hundred and fifteen type 2 DM patients (82 male and 133 female) and 209 healthy control group (79 male, 130 female) age, sex and body mass index(BMI) matched were included in the study. Duration of diabetes, HbA1c and presence of complications were analyzed. Cases with high se...

Background: Previously we have demonstrated expression of GH, IGF-1 and ghrelin, but not GHRH, in normal and malignant breast tissue. In vitro studies have suggested an inhibitory effect of ghrelin on proliferation of breast cancer cell lines. However the use of cell lines and dose of ghrelin may not represent physiological conditions.Objectives: (1) To establish a viable method for culturing fresh breast tissue explants, (2) to use this to investigate t...

Background: Acromegaly is a rare endocrine disorder characterized by sustained hypersecretion of growth hormone (GH) with concomitant elevation of insulin-like growth factor I (IGF-I) associated with acral enlargement, sleep apnea, cardiovascular and metabolic disorders. Its annual incidence is approximately six per million people. The most common cause of acromegaly is a somatotroph (growth hormone-secreting) adenoma of the anterior pituitary.Methods: A...

ObjectiveScanty data about glucose metabolism, hypertension and metabolic syndrome (MS) have been reported in Paget’s disease of bone (PDB) to be related with increased cardiovascular mortality. We aimed to determine prevalence of metabolic syndrome in PDB and to determine the relationship between metabolic syndrome and bone-specific alkaline phosphatase levels.Patients and methodsTwenty three patients w...

Objective: As a measure to reduce overtreatment, active surveillance (AS) for low-risk papillary thyroid carcinoma (PTC) has spread from Japan and gradually become accepted around the world. Older age is known to be a favorable factor for progression under AS; however, long-term evidence is still limited and lifelong monitoring is considered inevitable. The present study reviewed the results of AS from the 1990s and explored the possibility of completing follow-up.<p class...

Objectives: Active surveillance (AS) for low-risk papillary thyroid carcinoma (PTC) has been adopted as a reasonable approach to management worldwide. In our previous cross-sectional study, patients who chose AS had better mental patient-reported outcomes (PRO) compared to those who underwent immediate surgery. This prospective, longitudinal study aimed to compare PROs between patients who chose AS and those who underwent surgery, during a one-year follow-up from the time of d...

Background: The incidence of adrenal crisis remains constant, despite the introduction of behavioural interventions to educate and empower patients. To increase the success of future behaviour change interventions, theoretically informed and empirically supported behaviour change frameworks are available. The current review aimed to identify and evaluate available evidence of interventions used to prevent adrenal crisis in people with primary adrenal insufficiency to inform fu...